- PDB-6ng3: Crystal structure of human CD160 and HVEM complex -
+
Open data
ID or keywords:
Loading...
-
Basic information
Entry
Database: PDB / ID: 6ng3
Title
Crystal structure of human CD160 and HVEM complex
Components
CD160 antigen,Tumor necrosis factor receptor superfamily member 14
Keywords
IMMUNE SYSTEM / CD160 / HVEM / BTLA / gD
Function / homology
Function and homology information
positive regulation of natural killer cell mediated immune response to tumor cell / activating MHC class I receptor activity / negative regulation of CD4-positive, alpha-beta T cell costimulation / negative regulation of adaptive immune memory response / positive regulation of natural killer cell degranulation / negative regulation of alpha-beta T cell proliferation / MHC class I protein complex binding / mucosal immune response / MHC class Ib receptor activity / positive regulation of natural killer cell cytokine production ...positive regulation of natural killer cell mediated immune response to tumor cell / activating MHC class I receptor activity / negative regulation of CD4-positive, alpha-beta T cell costimulation / negative regulation of adaptive immune memory response / positive regulation of natural killer cell degranulation / negative regulation of alpha-beta T cell proliferation / MHC class I protein complex binding / mucosal immune response / MHC class Ib receptor activity / positive regulation of natural killer cell cytokine production / tumor necrosis factor receptor activity / MHC class I receptor activity / positive regulation of cytokine production involved in immune response / TNFs bind their physiological receptors / positive regulation of natural killer cell mediated cytotoxicity / positive regulation of endothelial cell apoptotic process / Costimulation by the CD28 family / negative regulation of T cell receptor signaling pathway / cytokine binding / positive regulation of T cell migration / side of membrane / T cell costimulation / negative regulation of angiogenesis / phosphatidylinositol 3-kinase/protein kinase B signal transduction / kinase binding / positive regulation of peptidyl-tyrosine phosphorylation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / positive regulation of type II interferon production / virus receptor activity / angiogenesis / defense response to Gram-negative bacterium / adaptive immune response / cell surface receptor signaling pathway / defense response to Gram-positive bacterium / immune response / external side of plasma membrane / innate immune response / signaling receptor binding / ubiquitin protein ligase binding / extracellular region / plasma membrane Similarity search - Function
CD160 ANTIGEN / Tumour necrosis factor receptor 14 / Tumor necrosis factor receptor 14/UL144, N-terminal / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold Similarity search - Domain/homology
Resolution: 2.88→20 Å / Cor.coef. Fo:Fc: 0.924 / Cor.coef. Fo:Fc free: 0.898 / SU B: 18.046 / SU ML: 0.344 / Cross valid method: THROUGHOUT / ESU R: 1.268 / ESU R Free: 0.388 / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.27363
344
4.7 %
RANDOM
Rwork
0.23415
-
-
-
obs
0.23614
6939
99.45 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å