登録情報 | データベース: PDB / ID: 7bed |
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タイトル | X-ray structure of WDR5 bound to the WDR5 win motif peptide |
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要素 | WD repeat-containing protein 5 |
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キーワード | TRANSFERASE / WD repeat-containing protein 5 LANA Histone Methyltransferase H3K4 / TRANSCRIPTION |
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機能・相同性 | 機能・相同性情報
MLL3/4 complex / Set1C/COMPASS complex / MLL1/2 complex / ATAC complex / NSL complex / histone H3K4 methyltransferase activity / Cardiogenesis / histone methyltransferase complex / regulation of tubulin deacetylation / Formation of WDR5-containing histone-modifying complexes ...MLL3/4 complex / Set1C/COMPASS complex / MLL1/2 complex / ATAC complex / NSL complex / histone H3K4 methyltransferase activity / Cardiogenesis / histone methyltransferase complex / regulation of tubulin deacetylation / Formation of WDR5-containing histone-modifying complexes / regulation of cell division / regulation of embryonic development / MLL1 complex / transcription factor TFIID complex / RNA polymerase II general transcription initiation factor activity / histone acetyltransferase complex / positive regulation of gluconeogenesis / transcription initiation-coupled chromatin remodeling / methylated histone binding / skeletal system development / gluconeogenesis / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / mitotic spindle / PKMTs methylate histone lysines / RMTs methylate histone arginines / Activation of anterior HOX genes in hindbrain development during early embryogenesis / Neddylation / HATs acetylate histones / histone binding / regulation of cell cycle / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleus類似検索 - 分子機能 G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.26 Å |
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データ登録者 | McVey, C.E. / Kaye, K.M. |
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資金援助 | ポルトガル, 米国, 5件 組織 | 認可番号 | 国 |
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Foundation for Science and Technology (FCT) | LISBOA-01-0145-FEDER-007344 | ポルトガル | Foundation for Science and Technology (FCT) | IF/01023/2013/CP1173/CT0003 | ポルトガル | National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | CA082036 | 米国 | National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | DE025208 | 米国 | National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | DE024971 | 米国 |
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引用 | ジャーナル: Nucleic Acids Res. / 年: 2021 タイトル: MLL1 is regulated by KSHV LANA and is important for virus latency. 著者: Tan, M. / Li, S. / Juillard, F. / Chitas, R. / Custodio, T.F. / Xue, H. / Szymula, A. / Sun, Q. / Liu, B. / Alvarez, A.L. / Chen, S. / Huang, J. / Simas, J.P. / McVey, C.E. / Kaye, K.M. |
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履歴 | 登録 | 2020年12月23日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年12月8日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年12月15日 | Group: Database references / カテゴリ: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2021年12月29日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2024年1月31日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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