登録情報 | データベース: PDB / ID: 6yw8 |
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タイトル | NMR solution structure of unbound recombinant human Nerve Growth Factor (rhNGF) |
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要素 | Beta-nerve growth factor |
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キーワード | HORMONE / human NGF / unbound structure / homodimer / cystin-knot |
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機能・相同性 | 機能・相同性情報
NFG and proNGF binds to p75NTR / Ceramide signalling / nerve growth factor receptor binding / NGF processing / TRKA activation by NGF / PLC-gamma1 signalling / Signalling to STAT3 / p75NTR negatively regulates cell cycle via SC1 / metalloendopeptidase inhibitor activity / nerve growth factor signaling pathway ...NFG and proNGF binds to p75NTR / Ceramide signalling / nerve growth factor receptor binding / NGF processing / TRKA activation by NGF / PLC-gamma1 signalling / Signalling to STAT3 / p75NTR negatively regulates cell cycle via SC1 / metalloendopeptidase inhibitor activity / nerve growth factor signaling pathway / nerve development / Retrograde neurotrophin signalling / Axonal growth stimulation / NADE modulates death signalling / Signalling to p38 via RIT and RIN / ARMS-mediated activation / positive regulation of Ras protein signal transduction / PI3K/AKT activation / NRAGE signals death through JNK / positive regulation of DNA binding / Frs2-mediated activation / extrinsic apoptotic signaling pathway via death domain receptors / Signalling to RAS / cell surface receptor protein tyrosine kinase signaling pathway / positive regulation of neuron differentiation / p75NTR recruits signalling complexes / NF-kB is activated and signals survival / NRIF signals cell death from the nucleus / neuron projection morphogenesis / endosome lumen / growth factor activity / modulation of chemical synaptic transmission / Golgi lumen / synaptic vesicle / positive regulation of peptidyl-serine phosphorylation / negative regulation of neuron apoptotic process / negative regulation of cell population proliferation / axon / lipid binding / dendrite / positive regulation of gene expression / extracellular space / extracellular region / cytosol類似検索 - 分子機能 Nerve growth factor, beta subunit, mammalian / Nerve growth factor, beta subunit / Nerve growth factor-related / Nerve growth factor conserved site / Nerve growth factor-like / Nerve growth factor family / Nerve growth factor family signature. / Nerve growth factor family profile. / Nerve growth factor (NGF or beta-NGF) / Cystine-knot cytokine類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Golic Grdadolnik, S. / Paoletti, F. |
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資金援助 | スロベニア, 3件 組織 | 認可番号 | 国 |
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Slovenian Research Agency | J1-8145 | スロベニア | Slovenian Research Agency | P1-0010 | スロベニア | Slovenian Research Agency | J1-1705 | スロベニア |
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引用 | ジャーナル: Comput Struct Biotechnol J / 年: 2021 タイトル: Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions. 著者: Paoletti, F. / Merzel, F. / Cassetta, A. / Ogris, I. / Covaceuszach, S. / Grdadolnik, J. / Lamba, D. / Golic Grdadolnik, S. |
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履歴 | 登録 | 2020年4月29日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年5月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年5月19日 | Group: Database references / カテゴリ: citation / citation_author / Item: _citation.pdbx_database_id_DOI / _citation.title |
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改定 1.2 | 2021年6月30日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.3 | 2024年7月3日 | Group: Data collection / Database references / Other カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data |
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