登録情報 | データベース: PDB / ID: 6yuh |
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タイトル | Crystal structure of SMYD3 with diperodon R enantiomer bound to allosteric site |
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要素 | Histone-lysine N-methyltransferase SMYD3 |
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キーワード | ONCOPROTEIN / Methyltransferase / complex / inhibitor |
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機能・相同性 | 機能・相同性情報
histone H3K36 dimethyltransferase activity / histone H4 methyltransferase activity / [histone H3]-lysine4 N-trimethyltransferase / myotube cell development / histone H3K4 trimethyltransferase activity / RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding / RNA polymerase II complex binding / cellular response to dexamethasone stimulus / establishment of protein localization / PKMTs methylate histone lysines ...histone H3K36 dimethyltransferase activity / histone H4 methyltransferase activity / [histone H3]-lysine4 N-trimethyltransferase / myotube cell development / histone H3K4 trimethyltransferase activity / RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding / RNA polymerase II complex binding / cellular response to dexamethasone stimulus / establishment of protein localization / PKMTs methylate histone lysines / nucleosome assembly / positive regulation of peptidyl-serine phosphorylation / methylation / RNA polymerase II cis-regulatory region sequence-specific DNA binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / metal ion binding / cytosol類似検索 - 分子機能 Histone-lysine N-methyltransferase Smyd3 / SMYD3, SET domain / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / : / MYND finger / Zinc finger, MYND-type / Zinc finger MYND-type signature. / Zinc finger MYND-type profile. / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily ...Histone-lysine N-methyltransferase Smyd3 / SMYD3, SET domain / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / : / MYND finger / Zinc finger, MYND-type / Zinc finger MYND-type signature. / Zinc finger MYND-type profile. / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / Tetratricopeptide-like helical domain superfamily類似検索 - ドメイン・相同性 Diperodon / S-ADENOSYLMETHIONINE / Histone-lysine N-methyltransferase SMYD3類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.93 Å |
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データ登録者 | Cederfelt, D. / Talibov, V.O. / Dobritzsch, D. / Danielson, U.H. |
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資金援助 | スウェーデン, イタリア, 2件 組織 | 認可番号 | 国 |
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Swedish Research Council | D0571301 | スウェーデン | Italian Association for Cancer Research | 19172 | イタリア |
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引用 | ジャーナル: Chembiochem / 年: 2021 タイトル: Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase. 著者: Talibov, V.O. / Fabini, E. / FitzGerald, E.A. / Tedesco, D. / Cederfeldt, D. / Talu, M.J. / Rachman, M.M. / Mihalic, F. / Manoni, E. / Naldi, M. / Sanese, P. / Forte, G. / Lepore Signorile, M. ...著者: Talibov, V.O. / Fabini, E. / FitzGerald, E.A. / Tedesco, D. / Cederfeldt, D. / Talu, M.J. / Rachman, M.M. / Mihalic, F. / Manoni, E. / Naldi, M. / Sanese, P. / Forte, G. / Lepore Signorile, M. / Barril, X. / Simone, C. / Bartolini, M. / Dobritzsch, D. / Del Rio, A. / Danielson, U.H. |
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履歴 | 登録 | 2020年4月27日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年1月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年5月12日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.name |
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改定 1.2 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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