PDB-6ye3: IL-2 in complex with a Fab fragment from UFKA-20

ID or keywords:

Entry

Database: PDB / ID: 6ye3

Title

IL-2 in complex with a Fab fragment from UFKA-20

Components

Chains: A,D,G
Chains: B,E,H
Interleukin-2

Keywords

PROTEIN BINDING / IL-2 / Fab / Treg

Function / homology

Function and homology information

kappa-type opioid receptor binding / regulation of CD4-positive, alpha-beta T cell proliferation / regulation of T cell homeostatic proliferation / interleukin-2 receptor binding / positive regulation of plasma cell differentiation / response to tacrolimus / glycosphingolipid binding / negative regulation of lymphocyte proliferation / positive regulation of tissue remodeling / negative regulation of T-helper 17 cell differentiation ...kappa-type opioid receptor binding / regulation of CD4-positive, alpha-beta T cell proliferation / regulation of T cell homeostatic proliferation / interleukin-2 receptor binding / positive regulation of plasma cell differentiation / response to tacrolimus / glycosphingolipid binding / negative regulation of lymphocyte proliferation / positive regulation of tissue remodeling / negative regulation of T-helper 17 cell differentiation / RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) / leukocyte activation involved in immune response / positive regulation of isotype switching to IgG isotypes / interleukin-2-mediated signaling pathway / activated T cell proliferation / natural killer cell activation / positive regulation of regulatory T cell differentiation / : / kinase activator activity / negative regulation of B cell apoptotic process / Interleukin-2 signaling / positive regulation of immunoglobulin production / positive regulation of dendritic spine development / positive regulation of activated T cell proliferation / positive regulation of interleukin-17 production / T cell differentiation / Interleukin receptor SHC signaling / positive regulation of B cell proliferation / positive regulation of tyrosine phosphorylation of STAT protein / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of protein phosphorylation / cytokine activity / growth factor activity / negative regulation of inflammatory response / positive regulation of inflammatory response / positive regulation of type II interferon production / cell-cell signaling / positive regulation of cytosolic calcium ion concentration / RAF/MAP kinase cascade / positive regulation of cell growth / carbohydrate binding / response to ethanol / adaptive immune response / transcription by RNA polymerase II / cell adhesion / immune response / positive regulation of cell population proliferation / negative regulation of apoptotic process / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region
Similarity search - Function

Biological species

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.89 Å

Authors

Karakus, U. / Mittl, P. / Boyman, O.

Citation

Journal: Sci Transl Med / Year: 2020
Title: Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species.
Authors: Karakus, U. / Sahin, D. / Mittl, P.R.E. / Mooij, P. / Koopman, G. / Boyman, O.

History

Deposition	Mar 23, 2020	Deposition site: PDBE / Processing site: PDBE
Revision 1.0	Dec 30, 2020	Provider: repository / Type: Initial release
Revision 1.1	Jan 24, 2024	Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	6ye3.cif.gz	833 KB	Display	PDBx/mmCIF format
PDB format	pdb6ye3.ent.gz	584.1 KB	Display	PDB format
PDBx/mmJSON format	6ye3.json.gz		Tree view	PDBx/mmJSON format
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Validation report

Summary document	6ye3_validation.pdf.gz	1.3 MB	Display	wwPDB validaton report
Full document	6ye3_full_validation.pdf.gz	1.3 MB	Display
Data in XML	6ye3_validation.xml.gz	62.5 KB	Display
Data in CIF	6ye3_validation.cif.gz	86.3 KB	Display
Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/ye/6ye3 ftp://data.pdbj.org/pub/pdb/validation_reports/ye/6ye3	HTTPS FTP

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Related structure data

Related structure data	5b6fS S: Starting model for refinement
Similar structure data	4z5r-8 4z5r-3 5vjo-1 4z5r-5 4m1g-d 4z5r-1 3d9a-d 1xgu-d 5nst-1 4a2c-d 4z5r-4 1xgr-d 5kvd-d 1xgp-d 2r00-1 5ggv-d Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

Related structure data

5b6fS

S: Starting model for refinement

Similar structure data

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#21 - Sep 2001 Antibodies similarity (1) #256 - Apr 2021 SARS-CoV-2 Spike and Antibodies similarity (1) #128 - Aug 2010 Interferons similarity (2) #52 - Apr 2004 Growth Hormone similarity (1) #149 - May 2012 Leptin similarity (1) #148 - Apr 2012 Ras Protein similarity (1)

Deposited unit

A: Chains: A,D,G

B: Chains: B,E,H

C: Interleukin-2

D: Chains: A,D,G

E: Chains: B,E,H

F: Interleukin-2

G: Chains: A,D,G

H: Chains: B,E,H

I: Interleukin-2

hetero molecules

269 kDa, 9 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Chains: A,D,G

B: Chains: B,E,H

C: Interleukin-2

hetero molecules

defined by author
89.6 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

D: Chains: A,D,G

E: Chains: B,E,H

F: Interleukin-2

hetero molecules

defined by author
89.6 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

3

G: Chains: A,D,G

H: Chains: B,E,H

I: Interleukin-2

hetero molecules

defined by author
89.6 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	238.384, 92.547, 121.892
Angle α, β, γ (deg.)	90.000, 100.112, 90.000
Int Tables number	5
Space group name H-M	C121
Space group name Hall	C2y
Symmetry operation	#1: x,y,z #2: -x,y,-z #3: x+1/2,y+1/2,z #4: -x+1/2,y+1/2,-z

Noncrystallographic symmetry (NCS)

NCS domain:

ID	Ens-ID
1	1
2	1
3	1
1	2
2	2
3	2
1	3
2	3
3	3

NCS domain segments:

Dom-ID	Component-ID	Ens-ID	Beg auth comp-ID	Beg label comp-ID	End auth comp-ID	End label comp-ID	Selection details	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
1	1	1	GLU	GLU	ASP	ASP	chain 'A'	A	A	1 - 223	1 - 223
2	2	1	GLU	GLU	ASP	ASP	(chain 'D' and resid 1 through 223)	D	D	1 - 223	1 - 223
3	3	1	GLU	GLU	ASP	ASP	(chain 'G' and resid 1 through 223)	G	G	1 - 223	1 - 223
1	4	2	ASP	ASP	ASN	ASN	chain 'B'	B	B	1 - 219	1 - 219
2	5	2	ASP	ASP	ASN	ASN	chain 'E'	E	E	1 - 219	1 - 219
3	6	2	ASP	ASP	ASN	ASN	chain 'H'	H	H	1 - 219	1 - 219
1	7	3	SER	SER	LEU	LEU	(chain 'C' and resid -1 through 127)	C	C	-1 - 127	5 - 133
2	8	3	SER	SER	LEU	LEU	(chain 'F' and resid -1 through 127)	F	F	-1 - 127	5 - 133
3	9	3	SER	SER	LEU	LEU	(chain 'I' and resid -1 through 127)	I	I	-1 - 127	5 - 133

NCS ensembles :

ID
1
2
3

#1: Antibody

Chains: A,D,G

Mass: 49417.715 Da / Num. of mol.: 3
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Homo sapiens (human) / Cell (production host): B-cell clone / Production host:

Homo sapiens (human)

#2: Antibody

Chains: B,E,H

Mass: 24150.686 Da / Num. of mol.: 3
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Homo sapiens (human) / Cell (production host): B-cell clone / Production host:

Homo sapiens (human)

#3: Protein

Interleukin-2 / IL-2 / T-cell growth factor / TCGF

Mass: 15567.178 Da / Num. of mol.: 3
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Homo sapiens (human) / Gene: IL2 / Production host:

Homo sapiens (human) / References: UniProt: P60568

#4: Polysaccharide

2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose

Type: oligosaccharide / Mass: 424.401 Da / Num. of mol.: 3
Source method: isolated from a genetically manipulated source

Descriptor	Type	Program
DGlcpNAcb1-4DGlcpNAcb1-	Glycam Condensed Sequence	GMML 1.0
WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1	WURCS	PDB2Glycan 1.1.0
[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}}	LINUCS	PDB-CARE

#5: Water

ChemComp-HOH / water

Mass: 18.015 Da / Num. of mol.: 91 / Source method: isolated from a natural source / Formula: H₂O

Has ligand of interest

N

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.48 Å³/Da / Density % sol: 50.3 %
Crystal grow	Temperature: 293 K / Method: vapor diffusion, sitting drop Details: 10.86% (v/v) PEG 8000, 5.76% (v/v) ethylene glycol, 100 mM HEPES, pH 7.48

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Data collection

Diffraction	Mean temperature: 100 K / Serial crystal experiment: N
Diffraction source	Source: SYNCHROTRON / Site: SLS / Beamline: X06DA / Wavelength: 1 Å
Detector	Type: DECTRIS PILATUS 2M / Detector: PIXEL / Date: Mar 5, 2019
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 1 Å / Relative weight: 1
Reflection	Resolution: 2.89→49.4 Å / Num. obs: 114189 / % possible obs: 99.7 % / Redundancy: 6.9 % / B_iso Wilson estimate: 99.35 Å² / CC_1/2: 0.992 / CC star: 0.998 / Net I/σ(I): 5.74
Reflection shell	Resolution: 2.89→2.993 Å / Redundancy: 6.6 % / Mean I/σ(I) obs: 0.38 / Num. unique obs: 5708 / CC_1/2: 0.186 / CC star: 0.56 / % possible all: 98.21

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Processing

Software

Name	Version	Classification
BUSTER		refinement
PHENIX	1.17.1_3660	refinement
XDS		data reduction
Aimless		data scaling
MOLREP		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: 5b6f

5b6f

Resolution: 2.89→49.4 Å / SU ML: 0.7233 / Cross valid method: FREE R-VALUE / σ(F): 1.18 / Phase error: 37.4927

	R_factor	Num. reflection	% reflection
R_free	0.2833	5726	5.01 %
R_work	0.2152	-	-
obs	0.2185	114189	99.26 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å

Displacement parameters

B_iso mean: 116.88 Å²

Refinement step

Cycle: LAST / Resolution: 2.89→49.4 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	13384	0	84	91	13559

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.0093	13778
X-RAY DIFFRACTION	f_angle_d	1.3172	18719
X-RAY DIFFRACTION	f_chiral_restr	0.067	2132
X-RAY DIFFRACTION	f_plane_restr	0.0087	2361
X-RAY DIFFRACTION	f_dihedral_angle_d	20.2772	5007

LS refinement shell

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Refine-ID	% reflection obs (%)
2.89-2.92	0.4397	166	0.4231	3101	X-RAY DIFFRACTION	88.08
2.92-2.96	0.449	192	0.4269	3711	X-RAY DIFFRACTION	99.92
2.96-2.99	0.4526	191	0.4213	3690	X-RAY DIFFRACTION	99.82
2.99-3.03	0.3865	188	0.4137	3538	X-RAY DIFFRACTION	99.73
3.03-3.07	0.4231	193	0.4097	3647	X-RAY DIFFRACTION	99.74
3.07-3.11	0.4464	195	0.4058	3673	X-RAY DIFFRACTION	99.85
3.11-3.16	0.3997	185	0.4146	3592	X-RAY DIFFRACTION	99.45
3.16-3.2	0.3636	194	0.3834	3675	X-RAY DIFFRACTION	99.69
3.2-3.25	0.4215	192	0.3486	3620	X-RAY DIFFRACTION	99.4
3.25-3.31	0.384	197	0.3616	3678	X-RAY DIFFRACTION	99.77
3.31-3.36	0.3792	192	0.334	3578	X-RAY DIFFRACTION	99.34
3.36-3.42	0.3373	190	0.3198	3626	X-RAY DIFFRACTION	99.66
3.42-3.49	0.3319	190	0.3008	3571	X-RAY DIFFRACTION	99.39
3.49-3.56	0.3692	193	0.2828	3700	X-RAY DIFFRACTION	99.59
3.56-3.64	0.3514	191	0.2773	3577	X-RAY DIFFRACTION	99.45
3.64-3.72	0.3369	190	0.2796	3634	X-RAY DIFFRACTION	99.51
3.72-3.82	0.2754	196	0.2572	3646	X-RAY DIFFRACTION	99.71
3.82-3.92	0.3221	189	0.2308	3631	X-RAY DIFFRACTION	99.61
3.92-4.03	0.3006	191	0.2131	3632	X-RAY DIFFRACTION	99.61
4.03-4.16	0.2535	191	0.197	3629	X-RAY DIFFRACTION	99.95
4.16-4.31	0.2804	192	0.1765	3601	X-RAY DIFFRACTION	99.82
4.31-4.49	0.2626	192	0.1632	3683	X-RAY DIFFRACTION	99.72
4.49-4.69	0.2342	195	0.1601	3607	X-RAY DIFFRACTION	99.66
4.69-4.94	0.2327	194	0.1528	3671	X-RAY DIFFRACTION	99.79
4.94-5.25	0.2219	193	0.1518	3590	X-RAY DIFFRACTION	99.24
5.25-5.65	0.2242	187	0.1538	3624	X-RAY DIFFRACTION	99.56
5.65-6.22	0.2425	194	0.1772	3623	X-RAY DIFFRACTION	99.5
6.22-7.11	0.3065	196	0.1867	3654	X-RAY DIFFRACTION	99.87
7.12-8.96	0.2286	189	0.1555	3628	X-RAY DIFFRACTION	99.92
8.96-49.4	0.2384	188	0.1693	3633	X-RAY DIFFRACTION	99.27

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	0.479569749733	0.0241554550243	-0.424077001031	0.0616261388584	-0.136128162285	0.822751376013	-0.0650807559541	0.571007266324	0.0573638867683	0.0687792743605	-0.14830037701	0.0671628300995	-0.215776695617	0.594029475508	-0.00487034192381	0.405712976659	0.0467226281583	0.00846117086666	0.745100518975	-0.15502246477	0.49417105375	-23.0880858286	-87.9584214198	60.3155621993
2	0.251952964917	0.0920826457548	0.284609089363	0.356557728342	0.652311604393	0.733127788579	-0.677141688611	0.735715530938	0.180720037665	-0.497084331271	0.702978827699	0.126287924217	-0.294821286565	0.0429897073003	0.000108184456809	0.745526443588	-0.177790793118	-0.042641276376	1.14613372396	0.0195723116496	0.87254431515	-50.5447460286	-88.8006898321	42.5531119997
3	1.08473736135	0.370707147356	-0.518900564995	0.982324980084	0.139757562237	0.740153035531	0.279689640686	-0.316100097164	-0.198526452304	0.176866185405	-0.188302596098	-0.0250087109794	0.0211531611408	0.044006352221	-3.39504673209E-5	0.623082503029	0.0283695638868	0.0399868433618	0.813085047863	-0.0808146630529	0.618497388371	-37.2674935414	-89.5866045298	76.8142251538
4	0.665080102582	0.153120903378	-0.272600685533	0.144472546634	0.888663837107	0.402075325043	0.122554960544	0.380354682762	0.0995265735972	0.0901888035911	0.23572196291	-0.124774344862	0.119227469481	-0.44724007568	-5.53017678914E-6	0.53234102595	-0.168835738948	0.011106069329	1.00418215157	-0.179777975266	0.65517430634	-59.1339656323	-100.784739857	47.4294367073
5	0.855228170658	0.0483394437685	-0.095545249073	0.673956467702	0.332240141142	1.08314381914	-0.0994062831503	0.000154936932658	-0.0476624910301	0.0830180921847	-0.0728611257661	-0.0355137051519	-0.240940731346	-0.0771495812425	7.48939780113E-5	0.539944002304	-0.0745886167059	-0.0670637917232	0.948368428116	-0.105111323598	0.710138922878	-10.1097950165	-75.4195975871	83.882006697
6	0.51043022228	-0.186670336676	0.754031748603	0.77528893286	0.0390846003578	0.54785779287	-0.4062994626	-0.0992827492581	0.209249114123	-0.124699854596	-0.0635788973585	0.126642304803	-0.321252386892	-0.0201318207074	-0.000441256226357	0.944703715027	0.216864195433	-0.181697176485	0.522555027798	-0.0261955649701	0.870692686028	-35.3621227307	-61.5614089767	2.34225451357
7	0.677181884511	-0.377925178698	0.363787022804	0.444988057826	-0.381752844981	0.762045763389	0.190048123894	0.888843813592	-0.120510562609	-0.202396110953	0.214818358595	0.105530220584	0.318795953833	1.78075346058	-0.000329726029367	0.996461843249	0.117508305158	0.0988117914362	1.21481561876	-0.237620593895	0.831198310555	-36.906156111	-27.9646735908	7.06845584883
8	0.497674946262	-0.0608762009515	-0.0329048866389	0.232688658643	-0.0546925043652	0.427219610394	-0.600084938571	-0.376631714614	0.12615528451	0.0814367763354	0.290273375255	-0.0587716540354	-0.605810631498	-0.0417471140741	-7.65354286442E-5	1.16302034287	0.263543833283	-0.33131930818	0.758811126156	-0.124784746907	0.894875795506	-30.9030722688	-61.2114715805	23.7351371101
9	0.121529078878	0.20527123564	0.193887032963	1.17656468382	1.13513982135	1.06660161962	0.307499107072	-0.080599349244	-0.519519532818	0.443197743953	0.305295104599	0.420608915756	0.0414082844015	0.478523873246	0.00031478246756	1.02466219489	0.0807723048844	0.0891503242231	0.651206308374	-0.101641822081	0.834070017755	-45.7707653798	-26.2874665418	19.2979617822
10	0.518890500899	-0.323200253067	0.315327759209	0.928297893633	0.151450712527	0.907746462895	0.137820224223	-0.107114169866	-0.149830325982	-0.129828163991	-0.00500321401743	-0.0866519965245	0.285922214666	0.630312562848	0.00162092034244	0.573732734443	0.194542797307	-0.0815084317524	0.575011920021	-0.0592407699592	0.632603183402	-21.3302075822	-87.1594887984	7.81091908881
11	0.439920731712	-0.0646866303202	0.0564757221368	1.52456303428	-0.459732787789	1.13605140107	-0.176806457021	-0.364677264845	-0.0217031015117	-0.511696769901	0.164071584998	0.335375822032	-0.165967199095	-4.0786793927E-5	-9.10436260416E-5	0.62595628066	-0.0641308844027	0.0957234493318	0.43440368453	-0.0676411589908	0.511728308118	-78.9343065134	-35.1840107785	13.495818075
12	0.126509119439	-0.26390046924	-0.164835476682	0.925724606204	0.464007462815	0.300144895517	0.615054616559	-0.97729861865	-0.541067447488	-0.434083301289	-0.00527526342046	0.154917007363	0.729856192567	-1.19735466065	0.0361607680467	0.776836006047	-0.440745401364	-0.288177782176	0.899993002475	0.494137921726	0.92937840196	-74.9391697918	-68.1730082775	17.3484371933
13	0.347188969202	-0.12926853384	0.353785765288	0.31298211021	0.187533051164	1.03419882987	0.15037524415	-0.775592187157	-0.130454648568	0.111889021966	0.180942125636	-0.178070345492	-0.0438969427757	0.692870367405	-9.95170781469E-5	0.591830692229	-0.0850854938044	0.069360472628	0.901020953445	-0.0418664023386	0.589411903496	-71.0299977881	-34.9569101562	33.8224626157
14	2.16933885328	-0.379330031577	0.731365860226	0.642628495909	0.271946771116	0.870295094777	0.982807962449	-1.59736487315	-0.853536637659	-0.0407039021615	0.507762077779	-0.137653566949	1.39926322164	-0.878742606285	0.350861590298	1.09545204419	0.0327387236389	-0.371550272248	0.287451266618	0.231762693359	1.04178874141	-60.8221509572	-70.2208518615	23.0797766255
15	0.167409370373	0.0970857058363	-0.140452618445	0.816500476215	0.313540142314	1.03683128953	-0.318754282109	-0.553694237614	0.298931379452	-0.00210406163676	0.0693529224814	0.398092834701	-0.453420229778	-0.279950567849	4.12959883259E-5	0.961998482671	0.127053454204	0.140724786499	0.751433276719	-0.118630698774	0.76514142547	-88.4947609696	-9.88340272428	25.6544069245

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	chain 'A' and (resid 1 through 124 )
2	X-RAY DIFFRACTION	2	chain 'A' and (resid 125 through 223 )
3	X-RAY DIFFRACTION	3	chain 'B' and (resid 1 through 114 )
4	X-RAY DIFFRACTION	4	chain 'B' and (resid 115 through 219 )
5	X-RAY DIFFRACTION	5	chain 'C' and (resid -2 through 128 )
6	X-RAY DIFFRACTION	6	chain 'D' and (resid 1 through 124 )
7	X-RAY DIFFRACTION	7	chain 'D' and (resid 125 through 225 )
8	X-RAY DIFFRACTION	8	chain 'E' and (resid 1 through 114 )
9	X-RAY DIFFRACTION	9	chain 'E' and (resid 115 through 219 )
10	X-RAY DIFFRACTION	10	chain 'F' and (resid -1 through 128 )
11	X-RAY DIFFRACTION	11	chain 'G' and (resid 1 through 124 )
12	X-RAY DIFFRACTION	12	chain 'G' and (resid 125 through 225 )
13	X-RAY DIFFRACTION	13	chain 'H' and (resid 1 through 114 )
14	X-RAY DIFFRACTION	14	chain 'H' and (resid 115 through 219 )
15	X-RAY DIFFRACTION	15	chain 'I' and (resid -3 through 128 )

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