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- PDB-5kvd: Zika specific antibody, ZV-2, bound to ZIKA envelope DIII -

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Basic information

Entry
Database: PDB / ID: 5kvd
TitleZika specific antibody, ZV-2, bound to ZIKA envelope DIII
Components
  • (ZV-2 Antibody Fab ...) x 2
  • Zika Envelope DIII
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / ZIKA VIRUS / ENVELOPE DIII / VIRAL PROTEIN / antibody / IgG2c / structural genomics / Center for Structural Genomics of Infectious Diseases / CSGID. / VIRAL PROTEIN-IMMUNE SYSTEM complex
Function / homology
Function and homology information


flavivirin / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / negative regulation of innate immune response / ribonucleoside triphosphate phosphatase activity / viral capsid / double-stranded RNA binding / nucleoside-triphosphate phosphatase / 4 iron, 4 sulfur cluster binding ...flavivirin / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / negative regulation of innate immune response / ribonucleoside triphosphate phosphatase activity / viral capsid / double-stranded RNA binding / nucleoside-triphosphate phosphatase / 4 iron, 4 sulfur cluster binding / mRNA (guanine-N7)-methyltransferase / methyltransferase cap1 / molecular adaptor activity / clathrin-dependent endocytosis of virus by host cell / methyltransferase cap1 activity / mRNA 5'-cap (guanine-N7-)-methyltransferase activity / RNA helicase activity / protein dimerization activity / host cell perinuclear region of cytoplasm / host cell endoplasmic reticulum membrane / RNA helicase / symbiont-mediated suppression of host innate immune response / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / symbiont entry into host cell / symbiont-mediated activation of host autophagy / RNA-directed RNA polymerase / serine-type endopeptidase activity / viral RNA genome replication / RNA-directed RNA polymerase activity / fusion of virus membrane with host endosome membrane / lipid binding / viral envelope / centrosome / GTP binding / virion attachment to host cell / host cell nucleus / virion membrane / structural molecule activity / ATP hydrolysis activity / proteolysis / extracellular region / ATP binding / metal ion binding / membrane
Similarity search - Function
Immunoglobulin-like - #350 / Flavivirus non-structural protein NS2B / Flavivirus capsid protein C superfamily / Genome polyprotein, Flavivirus / : / Flavivirus non-structural protein NS4A / Flavivirus non-structural protein NS2B / Flavivirus non-structural protein NS4B / mRNA cap 0/1 methyltransferase / Flavivirus non-structural protein NS4B ...Immunoglobulin-like - #350 / Flavivirus non-structural protein NS2B / Flavivirus capsid protein C superfamily / Genome polyprotein, Flavivirus / : / Flavivirus non-structural protein NS4A / Flavivirus non-structural protein NS2B / Flavivirus non-structural protein NS4B / mRNA cap 0/1 methyltransferase / Flavivirus non-structural protein NS4B / Flavivirus non-structural protein NS4A / Flavivirus NS2B domain profile. / mRNA cap 0 and cap 1 methyltransferase (EC 2.1.1.56 and EC 2.1.1.57) domain profile. / Flavivirus non-structural protein NS2A / Flavivirus non-structural protein NS2A / Flavivirus NS3, petidase S7 / Peptidase S7, Flavivirus NS3 serine protease / Flavivirus NS3 protease (NS3pro) domain profile. / RNA-directed RNA polymerase, thumb domain, Flavivirus / Flavivirus RNA-directed RNA polymerase, thumb domain / RNA-directed RNA polymerase, flavivirus / Flavivirus RNA-directed RNA polymerase, fingers and palm domains / Flavivirus capsid protein C / Flavivirus capsid protein C / Flavivirus non-structural Protein NS1 / Flavivirus non-structural protein NS1 / Envelope glycoprotein M, flavivirus / Envelope glycoprotein M superfamily, flavivirus / Flavivirus envelope glycoprotein M / Flavivirus polyprotein propeptide / Flavivirus polyprotein propeptide superfamily / Flavivirus polyprotein propeptide / Flavivirus envelope glycoprotein E, stem/anchor domain / : / Flavivirus NS3 helicase, C-terminal helical domain / Flavivirus envelope glycoprotein E, Stem/Anchor domain / Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily / Flavivirus glycoprotein E, immunoglobulin-like domain / Flavivirus glycoprotein, immunoglobulin-like domain / Flavivirus glycoprotein central and dimerisation domain / Flavivirus glycoprotein, central and dimerisation domains / Flaviviral glycoprotein E, central domain, subdomain 1 / Flaviviral glycoprotein E, central domain, subdomain 2 / Ribosomal RNA methyltransferase, FtsJ domain / FtsJ-like methyltransferase / Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily / Flavivirus glycoprotein, central and dimerisation domain superfamily / Flaviviral glycoprotein E, dimerisation domain / DEAD box, Flavivirus / Flavivirus DEAD domain / helicase superfamily c-terminal domain / Immunoglobulin E-set / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Peptidase S1, PA clan / DNA/RNA polymerase superfamily / Immunoglobulins / Immunoglobulin-like / Sandwich / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta
Similarity search - Domain/homology
Genome polyprotein / Genome polyprotein
Similarity search - Component
Biological speciesZika virus
Mus musculus (house mouse)
MethodX-RAY DIFFRACTION / SYNCHROTRON / Resolution: 1.65 Å
AuthorsZhao, H. / Nelson, C.A. / Fremont, D.H. / Center for Structural Genomics of Infectious Diseases (CSGID)
CitationJournal: Cell / Year: 2016
Title: Structural Basis of Zika Virus-Specific Antibody Protection.
Authors: Zhao, H. / Fernandez, E. / Dowd, K.A. / Speer, S.D. / Platt, D.J. / Gorman, M.J. / Govero, J. / Nelson, C.A. / Pierson, T.C. / Diamond, M.S. / Fremont, D.H.
History
DepositionJul 14, 2016Deposition site: RCSB / Processing site: RCSB
Revision 1.0Aug 3, 2016Provider: repository / Type: Initial release
Revision 1.1Aug 24, 2016Group: Database references
Revision 2.0Oct 23, 2024Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Polymer sequence / Structure summary
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / entity_poly / pdbx_entry_details / pdbx_modification_feature / pdbx_struct_conn_angle / pdbx_struct_oper_list / struct_conn / struct_conn_type
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity_poly.pdbx_seq_one_letter_code_can / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr2_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _pdbx_struct_oper_list.symmetry_operation / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr1_symmetry / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry / _struct_conn_type.id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
E: Zika Envelope DIII
L: ZV-2 Antibody Fab Light Chain
H: ZV-2 Antibody Fab Heavy Chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)60,3457
Polymers60,0413
Non-polymers3034
Water12,430690
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)39.020, 113.440, 132.970
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number19
Space group name H-MP212121

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Components

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Protein , 1 types, 1 molecules E

#1: Protein Zika Envelope DIII


Mass: 11935.734 Da / Num. of mol.: 1 / Fragment: UNP residues 589-697
Source method: isolated from a genetically manipulated source
Details: refolded / Source: (gene. exp.) Zika virus / Strain: French Polynesia H/PF/2013 / Plasmid: pET21a(+) / Production host: Escherichia coli (E. coli) / Strain (production host): BL21(DE3)RIL / References: UniProt: A0A024B7W1, UniProt: A0A0X8GJ44*PLUS

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Antibody , 2 types, 2 molecules LH

#2: Antibody ZV-2 Antibody Fab Light Chain


Mass: 24081.539 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Details: HYBRIDOMA MONOCLONAL ANTIBODY / Source: (natural) Mus musculus (house mouse) / Strain: C57BL/6, Irf3 knockout
#3: Antibody ZV-2 Antibody Fab Heavy Chain


Mass: 24023.961 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Mus musculus (house mouse) / Plasmid details: HYBRIDOMA MONOCLONAL ANTIBODY / Variant: Irf3 knockout / Strain: C57BL/6, Irf3 knockout

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Non-polymers , 4 types, 694 molecules

#4: Chemical ChemComp-NA / SODIUM ION


Mass: 22.990 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: Na
#5: Chemical ChemComp-MES / 2-(N-MORPHOLINO)-ETHANESULFONIC ACID


Mass: 195.237 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C6H13NO4S / Comment: pH buffer*YM
#6: Chemical ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL


Mass: 62.068 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C2H6O2
#7: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 690 / Source method: isolated from a natural source / Formula: H2O

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Details

Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.47 Å3/Da / Density % sol: 50.23 %
Crystal growTemperature: 293 K / Method: vapor diffusion, hanging drop / pH: 6.5 / Details: 0.1 M MES pH6.5, 0.6 M NaCl and 20.6% PEG 4000

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: ALS / Beamline: 4.2.2 / Wavelength: 1.00004 Å
DetectorType: RDI CMOS_8M / Detector: CMOS / Date: May 28, 2016
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1.00004 Å / Relative weight: 1
ReflectionResolution: 1.65→33.65 Å / Num. obs: 71401 / % possible obs: 98.9 % / Observed criterion σ(I): -3 / Redundancy: 6.7 % / Biso Wilson estimate: 20.95 Å2 / CC1/2: 0.999 / Rmerge(I) obs: 0.059 / Net I/σ(I): 18.76
Reflection shell
Resolution (Å)Highest resolution (Å)Rmerge(I) obsMean I/σ(I) obsCC1/2Diffraction-ID% possible all
1.65-1.690.9892.040.711100
1.69-1.740.8012.590.767199.9
1.74-1.790.593.440.8541100
1.79-1.840.4574.180.9051100
1.84-1.910.4754.080.925194.4
1.91-1.970.2716.570.971194.2
1.97-2.050.2018.980.979199.9
2.05-2.130.1611.950.985199.8
2.13-2.220.12814.280.992199.2
2.22-2.330.10816.470.992197
2.33-2.460.08220.770.9961100
2.46-2.610.06526.390.9971100
2.61-2.790.05330.850.9981100
2.79-3.010.04137.510.9991100
3.01-3.30.03344.210.9991100
3.3-3.690.03245.840.999199.9
3.69-4.260.03148.130.999199.7
4.26-5.220.02460.690.999199.9
5.22-7.380.02261.190.9991100
7.380.02161.040.999194.6

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Processing

Software
NameVersionClassification
XSCALEdata scaling
PHENIX1.10_2155refinement
PDB_EXTRACT3.2data extraction
XDSdata reduction
PHASERphasing
RefinementResolution: 1.65→33.65 Å / SU ML: 0.21 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 22.13
RfactorNum. reflection% reflection
Rfree0.2212 3558 4.99 %
Rwork0.19 --
obs0.1916 71267 98.81 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å
Displacement parametersBiso max: 145.48 Å2 / Biso mean: 31.6917 Å2 / Biso min: 10.57 Å2
Refinement stepCycle: final / Resolution: 1.65→33.65 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms4200 0 18 690 4908
Biso mean--34.31 38.55 -
Num. residues----550
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.0044391
X-RAY DIFFRACTIONf_angle_d0.7525998
X-RAY DIFFRACTIONf_chiral_restr0.049676
X-RAY DIFFRACTIONf_plane_restr0.005757
X-RAY DIFFRACTIONf_dihedral_angle_d12.962652
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
1.65-1.67260.30511500.28142600X-RAY DIFFRACTION97
1.6726-1.69650.2681320.27192752X-RAY DIFFRACTION100
1.6965-1.72180.29721580.26232656X-RAY DIFFRACTION100
1.7218-1.74870.26641280.25182709X-RAY DIFFRACTION100
1.7487-1.77740.28561250.24132731X-RAY DIFFRACTION100
1.7774-1.8080.27371520.23542665X-RAY DIFFRACTION100
1.808-1.84090.2551790.22552692X-RAY DIFFRACTION100
1.8409-1.87630.24531370.24612696X-RAY DIFFRACTION100
1.8763-1.91460.3641160.34412414X-RAY DIFFRACTION90
1.9146-1.95630.4111500.34492513X-RAY DIFFRACTION92
1.9563-2.00180.27661330.21512667X-RAY DIFFRACTION100
2.0018-2.05180.25321360.21252765X-RAY DIFFRACTION100
2.0518-2.10730.23181140.19432720X-RAY DIFFRACTION100
2.1073-2.16930.21581330.19132751X-RAY DIFFRACTION100
2.1693-2.23930.22531300.21012634X-RAY DIFFRACTION98
2.2393-2.31930.25861390.24932660X-RAY DIFFRACTION97
2.3193-2.41220.23871420.19622759X-RAY DIFFRACTION100
2.4122-2.52190.21081430.19362722X-RAY DIFFRACTION100
2.5219-2.65490.22141550.19222741X-RAY DIFFRACTION100
2.6549-2.82110.22991610.18682749X-RAY DIFFRACTION100
2.8211-3.03890.1971360.18092763X-RAY DIFFRACTION100
3.0389-3.34450.18881670.16752755X-RAY DIFFRACTION100
3.3445-3.82810.18941490.15062798X-RAY DIFFRACTION100
3.8281-4.82130.17741450.13612844X-RAY DIFFRACTION100
4.8213-33.650.18921480.15782953X-RAY DIFFRACTION99
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
10.00570.00560.0031-0.0009-0.0013-0.0034-0.07080.00050.0851-0.0656-0.04550.27330.0440.059800.57170.02080.05810.42680.00310.5446-13.191747.279-1.4946
2-0.0134-0.0377-0.01430.0214-0.01190.00360.00410.13330.2605-0.02220.05890.0648-0.22020.1642-0.00010.1815-0.01970.01070.16770.04120.1741-4.66549.0748-14.5086
30.00740.0085-0.0067-0.0009-0.0203-0.020.13870.18160.03740.0368-0.09840.0832-0.0056-0.002-00.14140.02280.01670.22790.04860.1933-17.871937.4797-23.6234
40.0683-0.0781-0.02670.1292-0.01270.01930.04730.10690.10360.1337-0.0277-0.0365-0.1115-0.063300.1829-0.00910.00060.16360.03190.172-5.929744.7912-13.0706
50.0143-0.0203-0.00490.05450.01950.0240.26610.12710.3641-0.07180.08930.0538-0.0772-0.09470.02730.26170.04460.07950.21930.11620.3732-17.077256.4565-21.7574
60.1388-0.03540.03230.01190.01690.04310.086-0.39980.26480.1620.12490.1552-0.1225-0.01420.05940.17290.01870.08750.20750.0020.2894-20.522849.4104-15.0548
70.029-0.0249-0.00120.0991-0.06250.04380.07880.07380.08870.0876-0.0578-0.00130.04110.0337-00.1527-0.0090.00430.18350.03860.1501-6.712841.0592-11.572
80.0113-0.0219-0.01330.07090.04680.0234-0.05810.19630.19890.12450.11080.1305-0.2525-0.15580.01370.1320.03510.01350.28050.10540.2444-20.156649.0778-23.9978
9-0.00010.0019-0.00320.0040.00520.0034-0.0148-0.03130.13980.16920.0111-0.1171-0.11940.0003-00.5213-0.0631-0.00350.21990.05880.3828-5.313156.0178-18.1614
100.10570.0920.04860.0879-0.00380.012-0.06310.34170.01370.1070.15-0.1242-0.1007-0.10210.00580.1796-0.00970.00220.30660.1130.2222-19.655846.6233-27.6042
110.0709-0.02970.10530.1839-0.00480.06660.16640.2092-0.3295-0.2477-0.28460.12120.1223-0.12170.00380.32630.0527-0.00090.3011-0.0540.2059-10.326812.1336-33.504
120.18750.1187-0.05920.6765-0.03390.28430.17240.22010.086-0.2888-0.1697-0.0570.1191-0.00250.00150.18010.0574-0.01470.23810.00890.1149-11.148424.5591-27.478
130.1960.07420.03560.2092-0.03160.09850.19990.0964-0.1117-0.2605-0.2069-0.02120.0065-0.0592-0.00360.28990.0994-0.00180.2555-0.00410.1501-8.006718.7367-32.6461
14-0.01010.0785-0.11550.05520.0198-0.05870.060.1167-0.0208-0.0967-0.0408-0.034-0.0265-0.073900.14430.0188-0.02180.184-0.06310.1504-7.210110.3672-28.222
150.1297-0.20460.14230.09850.16680.39710.04770.0657-0.02440.0813-0.0623-0.03080.1944-0.0635-0.00280.2171-0.0126-0.02110.174-0.08240.21445.3199-15.7477-22.3261
160.1021-0.0520.050.04760.01750.1582-0.02910.0433-0.02590.2950.01670.0661-0.2639-0.0339-0.11570.25430.03180.02420.1953-0.10080.27844.1591-3.706-25.5686
170.06330.0371-0.07160.0077-0.06690.05660.16430.165-0.08250.22030.05350.20420.6459-0.31890.10630.5786-0.1252-0.02810.179-0.03820.27692.9586-22.0874-17.9717
180.07840.04560.01270.05240.03950.05240.30170.89170.11610.26290.1224-0.20550.2489-0.59760.16610.3356-0.1-0.1645-0.2034-0.30350.2127.1278-21.1162-29.5926
190.43650.0148-0.25220.14410.00140.11510.00120.0686-0.04460.0295-0.02790.01220.02220.046400.1238-0.0023-0.00890.0974-0.00620.1241-6.096421.4904-6.1864
200.44960.2171-0.11360.1204-0.12990.29970.12750.13540.0313-0.02830.0030.14630.1766-0.09650.16430.1752-0.0051-0.03630.1207-0.03590.0924-13.422415.6066-12.7178
210.1182-0.0087-0.08140.0211-0.01890.0550.0222-0.00570.05030.0446-0.0111-0.0530.0317-0.10190.00020.1513-0.02630.00980.1377-0.03670.1476-19.879819.145-5.8822
220.3701-0.20290.08690.1659-0.05440.2726-0.00490.0488-0.01650.022-0.02610.03870.0620.0321-00.15170.00060.00850.1195-0.00820.1452-7.793717.5439-7.369
230.00410.01060.01940.05520.00810.02380.18510.007-0.2525-0.0817-0.0625-0.1380.29120.0385-0.04780.41380.148-0.04910.2987-0.21320.377917.1892-17.6174-19.6317
240.0134-0.1611-0.01340.1868-0.18840.2367-0.12430.1153-0.02330.10890.1969-0.0697-0.04560.05490.02430.22570.0133-0.00260.2951-0.12320.289512.0328-5.0847-15.2045
250.0871-0.00920.07170.0933-0.11430.1529-0.1115-0.1172-0.13380.20430.213-0.0869-0.0540.4498-0.00420.29160.0792-0.0350.3676-0.16070.362121.3931-10.4811-12.8445
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain 'E' and (resid 298 through 302 )E298 - 302
2X-RAY DIFFRACTION2chain 'E' and (resid 303 through 311 )E303 - 311
3X-RAY DIFFRACTION3chain 'E' and (resid 312 through 322 )E312 - 322
4X-RAY DIFFRACTION4chain 'E' and (resid 323 through 339 )E323 - 339
5X-RAY DIFFRACTION5chain 'E' and (resid 340 through 348 )E340 - 348
6X-RAY DIFFRACTION6chain 'E' and (resid 349 through 358 )E349 - 358
7X-RAY DIFFRACTION7chain 'E' and (resid 359 through 375 )E359 - 375
8X-RAY DIFFRACTION8chain 'E' and (resid 376 through 386 )E376 - 386
9X-RAY DIFFRACTION9chain 'E' and (resid 387 through 392 )E387 - 392
10X-RAY DIFFRACTION10chain 'E' and (resid 393 through 402 )E393 - 402
11X-RAY DIFFRACTION11chain 'L' and (resid 1 through 25 )L1 - 25
12X-RAY DIFFRACTION12chain 'L' and (resid 26 through 61 )L26 - 61
13X-RAY DIFFRACTION13chain 'L' and (resid 62 through 90 )L62 - 90
14X-RAY DIFFRACTION14chain 'L' and (resid 91 through 113 )L91 - 113
15X-RAY DIFFRACTION15chain 'L' and (resid 114 through 155 )L114 - 155
16X-RAY DIFFRACTION16chain 'L' and (resid 156 through 174 )L156 - 174
17X-RAY DIFFRACTION17chain 'L' and (resid 175 through 197 )L175 - 197
18X-RAY DIFFRACTION18chain 'L' and (resid 198 through 214 )L198 - 214
19X-RAY DIFFRACTION19chain 'H' and (resid 2 through 39 )H2 - 39
20X-RAY DIFFRACTION20chain 'H' and (resid 40 through 52 )H40 - 52
21X-RAY DIFFRACTION21chain 'H' and (resid 53 through 66 )H53 - 66
22X-RAY DIFFRACTION22chain 'H' and (resid 67 through 119 )H67 - 119
23X-RAY DIFFRACTION23chain 'H' and (resid 120 through 136 )H120 - 136
24X-RAY DIFFRACTION24chain 'H' and (resid 137 through 194 )H137 - 194
25X-RAY DIFFRACTION25chain 'H' and (resid 195 through 230 )H195 - 230

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