登録情報 | データベース: PDB / ID: 6xe7 |
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タイトル | Carbonmonoxy hemoglobin in complex with the antisickling agent methyl 2-((2-formyl-3-hydroxyphenoxy)methyl)nicotinate |
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要素 | (Hemoglobin subunit ...) x 2 |
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キーワード | OXYGEN TRANSPORT / Hemoglobin / Antisickling / Aromatic aldehyde / Allosteric effector |
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機能・相同性 | 機能・相同性情報
nitric oxide transport / hemoglobin alpha binding / cellular oxidant detoxification / hemoglobin binding / haptoglobin-hemoglobin complex / renal absorption / organic acid binding / hemoglobin complex / oxygen transport / Scavenging of heme from plasma ...nitric oxide transport / hemoglobin alpha binding / cellular oxidant detoxification / hemoglobin binding / haptoglobin-hemoglobin complex / renal absorption / organic acid binding / hemoglobin complex / oxygen transport / Scavenging of heme from plasma / endocytic vesicle lumen / blood vessel diameter maintenance / platelet aggregation / hydrogen peroxide catabolic process / oxygen carrier activity / Late endosomal microautophagy / carbon dioxide transport / Heme signaling / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / response to hydrogen peroxide / Cytoprotection by HMOX1 / oxygen binding / regulation of blood pressure / Chaperone Mediated Autophagy / positive regulation of nitric oxide biosynthetic process / tertiary granule lumen / Factors involved in megakaryocyte development and platelet production / ficolin-1-rich granule lumen / blood microparticle / iron ion binding / heme binding / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / membrane / metal ion binding / cytosol類似検索 - 分子機能 Hemoglobin, pi / Hemoglobin, alpha-type / Hemoglobin, beta-type / : / Globin/Protoglobin / Globin domain profile. / Globin / Globin / Globin-like superfamily類似検索 - ドメイン・相同性 CARBON MONOXIDE / PROTOPORPHYRIN IX CONTAINING FE / Chem-V2D / Hemoglobin subunit beta / Hemoglobin subunit alpha類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2 Å |
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データ登録者 | Pagare, P.P. / Safo, M.K. / Musayev, F.N. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | RO1MD009124 | 米国 | National Institutes of Health/Office of the Director | S10OD021756 | 米国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2020 タイトル: Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents. 著者: Pagare, P.P. / Ghatge, M.S. / Chen, Q. / Musayev, F.N. / Venitz, J. / Abdulmalik, O. / Zhang, Y. / Safo, M.K. |
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履歴 | 登録 | 2020年6月12日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年12月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年12月23日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.2 | 2023年10月18日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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