PDB-6x27: Lon protease proteolytic domain complexed with bortezomib

Basic information

• Entry: Database: PDB / ID: 6x27
• Title: Lon protease proteolytic domain complexed with bortezomib
• Components: Lon protease homolog, mitochondrial
• Keywords: HYDROLASE/HYDROLASE inhibitor / covalent inhibitor / proteolytic domain / HYDROLASE / HYDROLASE-HYDROLASE inhibitor complex

Function / homology

Function:

oxidation-dependent protein catabolic process / response to aluminum ion / PH domain binding / endopeptidase La / mitochondrial protein catabolic process / mitochondrial DNA metabolic process / G-quadruplex DNA binding / : / ATP-dependent peptidase activity / protein quality control for misfolded or incompletely synthesized proteins / mitochondrial nucleoid / insulin receptor substrate binding / Mitochondrial unfolded protein response (UPRmt) / chaperone-mediated protein complex assembly / response to hormone / DNA polymerase binding / Mitochondrial protein degradation / negative regulation of insulin receptor signaling pathway / proteolysis involved in protein catabolic process / mitochondrion organization / protein catabolic process / ADP binding / single-stranded DNA binding / cellular response to oxidative stress / sequence-specific DNA binding / response to hypoxia / single-stranded RNA binding / mitochondrial matrix / serine-type endopeptidase activity / ATP hydrolysis activity / mitochondrion / nucleoplasm / ATP binding / identical protein binding / membrane / cytosol

Domain/homology:

Lon protease homologue, chloroplastic/mitochondrial / : / Lon protease, bacterial/eukaryotic-type / Lon protease AAA+ ATPase lid domain / Peptidase S16, active site / ATP-dependent serine proteases, lon family, serine active site. / Lon proteolytic domain profile. / Peptidase S16, Lon proteolytic domain / Lon protease / Lon protease (S16) C-terminal proteolytic domain / Lon N-terminal domain profile. / Lon protease, N-terminal domain / Lon protease, N-terminal domain superfamily / ATP-dependent protease La (LON) substrate-binding domain / Found in ATP-dependent protease La (LON) / Ribosomal Protein S5; domain 2 - #10 / PUA-like superfamily / Ribosomal Protein S5; domain 2 / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / Ribosomal protein S5 domain 2-type fold, subgroup / Ribosomal protein S5 domain 2-type fold / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase / 2-Layer Sandwich / Alpha Beta

Component:

Chem-BO2 / Lon protease homolog, mitochondrial

• Biological species: Homo sapiens (human)
• Method: X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.12 Å
• Authors: Lee, C.C. / Spraggon, G.
• Citation: Journal: J.Med.Chem. / Year: 2021; Title: Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology.; Authors: Kingsley, L.J. / He, X. / McNeill, M. / Nelson, J. / Nikulin, V. / Ma, Z. / Lu, W. / Zhou, V.W. / Manuia, M. / Kreusch, A. / Gao, M.Y. / Witmer, D. / Vaillancourt, M.T. / Lu, M. / Greenblatt, S. / Lee, C. / Vashisht, A. / Bender, S. / Spraggon, G. / Michellys, P.Y. / Jia, Y. / Haling, J.R. / Lelais, G.

History

Deposition	May 20, 2020	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Apr 14, 2021	Provider: repository / Type: Initial release
Revision 1.1	Apr 21, 2021	Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
Revision 1.2	May 5, 2021	Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID
Revision 1.3	Oct 18, 2023	Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 1.4	Oct 23, 2024	Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature / Item: _pdbx_entry_details.has_protein_modification

Assembly

Deposited unit

A: Lon protease homolog, mitochondrial

B: Lon protease homolog, mitochondrial

C: Lon protease homolog, mitochondrial

D: Lon protease homolog, mitochondrial

E: Lon protease homolog, mitochondrial

F: Lon protease homolog, mitochondrial

G: Lon protease homolog, mitochondrial

H: Lon protease homolog, mitochondrial

I: Lon protease homolog, mitochondrial

J: Lon protease homolog, mitochondrial

K: Lon protease homolog, mitochondrial

L: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• 292 kDa, 12 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	291,683	32
Polymers	285,459	12
Non-polymers	6,225	20
Water	28,662	1591

1

A: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• defined by author
• Evidence: gel filtration
• 24.4 kDa, 1 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	24,411	3
Polymers	23,788	1
Non-polymers	623	2
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

2

B: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• defined by author
• 24.4 kDa, 1 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	24,411	3
Polymers	23,788	1
Non-polymers	623	2
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

3

C: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• defined by author
• 24.4 kDa, 1 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	24,411	3
Polymers	23,788	1
Non-polymers	623	2
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

4

D: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• defined by author
• 24.2 kDa, 1 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	24,172	2
Polymers	23,788	1
Non-polymers	384	1
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

5

E: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• defined by author
• 24.2 kDa, 1 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	24,172	2
Polymers	23,788	1
Non-polymers	384	1
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

6

F: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• defined by author
• 24.4 kDa, 1 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	24,411	3
Polymers	23,788	1
Non-polymers	623	2
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

7

G: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• defined by author
• 24.3 kDa, 1 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	24,265	3
Polymers	23,788	1
Non-polymers	476	2
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

8

H: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• defined by author
• 24.4 kDa, 1 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	24,411	3
Polymers	23,788	1
Non-polymers	623	2
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

9

I: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• defined by author
• 24.4 kDa, 1 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	24,411	3
Polymers	23,788	1
Non-polymers	623	2
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

10

J: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• defined by author
• 24.2 kDa, 1 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	24,172	2
Polymers	23,788	1
Non-polymers	384	1
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

11

K: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• defined by author
• 24.2 kDa, 1 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	24,172	2
Polymers	23,788	1
Non-polymers	384	1
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

12

L: Lon protease homolog, mitochondrial

hetero molecules

Summary:

• defined by author
• 24.3 kDa, 1 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	24,265	3
Polymers	23,788	1
Non-polymers	476	2
Water	18	1

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Unit cell

Length a, b, c (Å)	175.373, 175.373, 206.189
Angle α, β, γ (deg.)	90.000, 90.000, 90.000
Int Tables number	96
Space group name H-M	P43212

Components

#1: Protein

A B C D E F G H I J K L
Lon protease homolog, mitochondrial / LONHs / Lon protease-like protein / LONP / Mitochondrial ATP-dependent protease Lon / Serine protease 15

Details:

Mass: 23788.221 Da / Num. of mol.: 12
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: LONP1, PRSS15 / Production host: Escherichia coli (E. coli) / References: UniProt: P36776, endopeptidase La

#2: Chemical

A-1001 B-1001 C-1001 D-1001 E-1001 F-1001 G-1001 H-1001 I-1001 J-1001 K-1001 L-1001
ChemComp-BO2 / N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE / BORTEZOMIB

Details:

Mass: 384.237 Da / Num. of mol.: 12 / Source method: obtained synthetically / Formula: C₁₉H₂₅BN₄O₄ / Feature type: SUBJECT OF INVESTIGATION / Comment: medication*YM

#3: Chemical

A-1002 B-1002 C-1002 F-1002 H-1002 I-1002
ChemComp-1PE / PENTAETHYLENE GLYCOL / PEG400

Details:

Mass: 238.278 Da / Num. of mol.: 6 / Source method: obtained synthetically / Formula: C₁₀H₂₂O₆ / Comment: precipitant*YM

#4: Chemical

G-1002 L-1002 ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL

Details:

Mass: 92.094 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₃H₈O₃

#5: Water

ChemComp-HOH / water

Details:

Mass: 18.015 Da / Num. of mol.: 1591 / Source method: isolated from a natural source / Formula: H₂O

• Has ligand of interest: Y
• Has protein modification: Y

Experimental details

Experiment

• Experiment: Method: X-RAY DIFFRACTION / Number of used crystals: 1

Sample preparation

• Crystal: Density Matthews: 2.78 ų/Da / Density % sol: 55.71 %
• Crystal grow: Temperature: 293 K / Method: vapor diffusion, sitting drop / pH: 4 / Details: 5.0% polyethylene glycol 6000, 0.1M citric acid

Data collection

• Diffraction: Mean temperature: 100 K / Serial crystal experiment: N
• Diffraction source: Source: SYNCHROTRON / Site: ALS / Beamline: 5.0.3 / Wavelength: 0.9765 Å
• Detector: Type: ADSC QUANTUM 315r / Detector: CCD / Date: Jul 20, 2016
• Radiation: Monochromator: Si(220) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
• Radiation wavelength: Wavelength: 0.9765 Å / Relative weight: 1
• Reflection: Resolution: 2.12→50 Å / Num. obs: 180816 / % possible obs: 100 % / Redundancy: 14.7 % / R_merge(I) obs: 0.215 / R_pim(I) all: 0.058 / R_rim(I) all: 0.223 / Χ²: 1.055 / Net I/σ(I): 4.1 / Num. measured all: 2654083

Reflection shell

Diffraction-ID: 1

Resolution (Å)	Redundancy (%)	Rmerge(I) obs	Num. unique obs	CC1/2	Rpim(I) all	Rrim(I) all	Χ2	% possible all
2.12-2.14	11.7	1.047	5914	0.794	0.318	1.095	0.721	99.7
2.14-2.17	13.1	1.048	5944	0.832	0.3	1.091	0.714	100
2.17-2.2	13.7	1.013	5984	0.847	0.283	1.052	0.732	100
2.2-2.22	14.8	0.994	5950	0.863	0.268	1.03	0.733	100
2.22-2.25	15	0.91	5971	0.892	0.243	0.942	0.768	100
2.25-2.28	15	0.781	5951	0.921	0.208	0.808	0.765	100
2.28-2.32	15	0.713	5983	0.93	0.19	0.738	0.764	100
2.32-2.35	15.1	0.635	5948	0.942	0.169	0.657	0.769	100
2.35-2.39	15.1	0.595	5959	0.947	0.158	0.616	0.775	100
2.39-2.43	15.1	0.589	5996	0.947	0.157	0.61	0.776	100
2.43-2.47	15.1	0.544	5953	0.955	0.145	0.563	0.78	100
2.47-2.51	15	0.535	5997	0.954	0.142	0.554	0.793	100
2.51-2.56	15.1	0.485	5970	0.959	0.129	0.502	0.791	100
2.56-2.61	15	0.443	5995	0.969	0.118	0.459	0.798	100
2.61-2.67	15.1	0.387	5975	0.975	0.103	0.401	0.832	100
2.67-2.73	15	0.349	6025	0.98	0.093	0.361	0.845	100
2.73-2.8	15	0.319	5976	0.983	0.085	0.33	0.865	100
2.8-2.88	15	0.27	6019	0.988	0.072	0.279	0.9	100
2.88-2.96	15	0.233	6011	0.99	0.062	0.241	0.942	100
2.96-3.06	15	0.205	5995	0.992	0.055	0.213	0.97	100
3.06-3.17	15	0.181	6027	0.994	0.048	0.187	1.025	100
3.17-3.29	15	0.165	6043	0.994	0.044	0.17	1.074	100
3.29-3.44	14.9	0.14	6055	0.996	0.037	0.145	1.151	100
3.44-3.62	14.9	0.119	6038	0.996	0.032	0.123	1.362	100
3.62-3.85	14.8	0.115	6065	0.997	0.031	0.119	1.712	100
3.85-4.15	14.6	0.116	6092	0.996	0.031	0.12	2.082	100
4.15-4.57	14.4	0.103	6108	0.997	0.028	0.107	2.495	100
4.57-5.23	14.4	0.094	6156	0.997	0.026	0.097	2.111	100
5.23-6.58	14.2	0.091	6212	0.998	0.025	0.094	1.214	100
6.58-50	14.2	0.051	6504	0.999	0.014	0.053	1.283	99.9

Processing

Software

Name	Version	Classification
SCALEPACK		data scaling
PHENIX	1.17_3644	refinement
PDB_EXTRACT	3.25	data extraction
HKL-2000		data reduction
MOLREP		phasing

Refinement

Method to determine structure: MOLECULAR REPLACEMENT
Starting model: 6WYS

6wys

Resolution: 2.12→46.04 Å / SU ML: 0.19 / Cross valid method: THROUGHOUT / σ(F): 1.36 / Phase error: 17.52 / Stereochemistry target values: ML

	Rfactor	Num. reflection	% reflection
Rfree	0.1941	8832	4.89 %
Rwork	0.1572	171844	-
obs	0.159	180676	99.96 %

• Solvent computation: Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
• Displacement parameters: B_iso max: 107.13 Ų / B_iso mean: 26.2282 Ų / B_iso min: 3.56 Ų

Refinement step

Cycle: final / Resolution: 2.12→46.04 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	16771	0	526	1591	18888
Biso mean	-	-	27.5	35.89	-
Num. residues	-	-	-	-	2249

LS refinement shell

Refine-ID: X-RAY DIFFRACTION / R_factor R_free error: 0 / Total num. of bins used: 30

Resolution (Å)	Rfactor Rfree	Num. reflection Rfree	Rfactor Rwork	Num. reflection Rwork	Num. reflection all	% reflection obs (%)
2.12-2.14	0.2411	292	0.1937	5592	5884	99
2.14-2.17	0.2508	308	0.1857	5635	5943	100
2.17-2.2	0.2357	296	0.1814	5695	5991	100
2.2-2.22	0.2317	305	0.1801	5631	5936	100
2.22-2.25	0.2296	299	0.1762	5682	5981	100
2.25-2.28	0.2253	281	0.1716	5666	5947	100
2.28-2.32	0.2167	310	0.169	5658	5968	100
2.32-2.35	0.2292	278	0.1602	5688	5966	100
2.35-2.39	0.1916	266	0.156	5688	5954	100
2.39-2.43	0.2061	298	0.159	5695	5993	100
2.43-2.47	0.2163	306	0.1616	5644	5950	100
2.47-2.51	0.2051	310	0.1623	5695	6005	100
2.51-2.56	0.1856	291	0.1593	5676	5967	100
2.56-2.61	0.2201	270	0.1631	5718	5988	100
2.61-2.67	0.211	317	0.1588	5666	5983	100
2.67-2.73	0.2177	261	0.1657	5750	6011	100
2.73-2.8	0.2108	301	0.1605	5680	5981	100
2.8-2.88	0.1905	280	0.1542	5741	6021	100
2.88-2.96	0.1886	300	0.1486	5698	5998	100
2.96-3.06	0.1777	308	0.1525	5693	6001	100
3.06-3.17	0.2036	296	0.1614	5730	6026	100
3.17-3.29	0.2057	287	0.1606	5756	6043	100
3.29-3.44	0.2074	304	0.1563	5746	6050	100
3.44-3.63	0.1763	286	0.1507	5747	6033	100
3.63-3.85	0.1789	305	0.1428	5762	6067	100
3.85-4.15	0.1704	291	0.1336	5800	6091	100
4.15-4.57	0.1403	297	0.1206	5797	6094	100
4.57-5.23	0.1578	291	0.135	5865	6156	100
5.23-6.58	0.2002	300	0.1802	5903	6203	100
6.58-46.04	0.1896	298	0.188	6147	6445	99

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	3.8938	-0.9763	3.5733	1.5448	-0.378	5.8112	-0.0401	0.1591	0.3235	0.08	-0.0064	-0.2986	-0.3149	0.3893	0.0075	0.122	-0.0021	0.0211	0.1522	-0.0154	0.1811	79.9599	-40.5323	-105.2008
2	2.2484	1.1993	1.4241	4.0504	1.3087	4.8706	-0.1821	-0.7393	-0.3386	0.6513	0.0268	-0.0827	-0.0152	0.0881	0.1056	0.1858	0.0311	0.0288	0.3584	0.069	0.1884	72.1731	-49.3235	-92.9375
3	2.6255	-3.1687	1.6959	6.0288	-1.3961	4.4583	-0.1873	-0.2441	-0.2172	0.3695	0.1357	-0.0547	0.251	-0.1081	0.0296	0.1373	-0.0299	0.0085	0.1383	0.0108	0.1376	74.6767	-57.6622	-100.7677
4	6.6236	-5.6276	-0.1914	6.8951	0.8247	2.1799	-0.3003	-0.4555	-0.4468	0.7026	0.2669	0.1047	0.3618	0.1913	0.062	0.1985	0.0257	-0.0381	0.2351	0.0044	0.1687	80.0665	-54.6776	-91.5281
5	1.341	-0.3077	0.0955	1.2724	0.0709	1.4236	-0.036	-0.0016	0.0488	-0.0123	0.0446	-0.1221	-0.0069	0.1773	0.0006	0.0922	-0.0135	0.0147	0.1284	-0.0138	0.1222	78.6164	-49.5059	-106.3831
6	6.2741	-0.3628	1.0422	1.4154	0.9703	3.9979	-0.0915	0.065	0.5347	-0.3119	0.0365	-0.28	-0.6325	0.0461	0.0869	0.1479	-0.0303	0.0557	0.2022	0.0195	0.1901	81.1501	-39.2615	-118.2402
7	1.8396	-0.5381	0.6111	2.475	-3.3391	6.3497	0.0776	0.1374	-0.0148	-0.1463	-0.1183	-0.1166	0.1526	0.317	0.056	0.1168	0.0277	0.0501	0.1677	-0.0372	0.1678	84.2798	-50.4042	-118.6369
8	3.6618	-2.9032	1.8842	7.3996	-2.7601	2.296	-0.1591	-0.2496	0.1752	0.2436	0.1185	0.1456	-0.205	0.1282	0.0668	0.1052	-0.0234	0.003	0.1857	-0.0311	0.1627	14.2361	-23.9567	-92.3022
9	4.21	-1.1664	1.3125	2.8019	-0.4527	3.5724	-0.0997	0.3874	0.1358	-0.3119	-0.0038	0.0945	-0.1155	-0.034	0.0595	0.1914	-0.0266	-0.013	0.1697	0.0111	0.1582	13.4107	-28.9201	-108.3168
10	6.1572	2.5142	4.0876	1.1585	2.1533	4.5365	-0.3061	0.3141	0.2193	-0.4328	0.2479	0.3553	-0.711	-0.0369	0.045	0.2637	-0.0009	-0.1003	0.2163	0.0518	0.3167	9.9175	-20.1181	-110.9879
11	1.205	0.3028	0.21	1.8171	-0.3638	1.4228	-0.0202	-0.0361	0.0297	-0.0235	0.045	0.2121	-0.0471	-0.1698	-0.0134	0.1077	0.0144	0.0041	0.1704	-0.012	0.1787	10.4303	-29.6794	-98.346
12	8.8137	-5.803	-3.8232	4.4609	3.4091	5.7094	-0.2009	-0.4962	0.286	0.379	0.2513	-0.1043	0.1245	0.079	-0.1243	0.1446	-0.0106	0.0397	0.2415	-0.0069	0.1613	10.992	-32.44	-82.8166
13	1.7237	-0.8736	1.164	2.4649	-2.9328	6.0909	-0.0228	-0.0421	-0.0898	0.0844	0.1608	0.4037	-0.0379	-0.502	-0.1268	0.0909	-0.0099	0.04	0.2391	-0.0191	0.2772	2.4233	-36.1334	-89.7872
14	2.3793	-1.2724	1.617	1.2583	-1.4187	6.8264	-0.2198	-0.253	0.2075	0.2139	0.1392	0.0593	-0.3766	-0.001	0.0574	0.1408	0.0039	-0.0236	0.1624	-0.0382	0.1798	67.1105	-23.9073	-81.6508
15	6.0942	-0.9612	2.0895	5.2127	-1.9872	8.0669	-0.2862	-0.3427	-0.5714	0.6405	0.2311	-0.3062	0.2878	0.0064	0.0666	0.1973	0.0158	0.0079	0.1577	-0.0154	0.2044	65.1846	-40.0293	-79.9534
16	6.8451	-0.8198	5.3424	4.021	-0.9594	6.2454	-0.0842	-0.0477	-0.2927	0.097	0.1424	-0.2161	0.0186	0.1055	-0.137	0.1154	-0.0023	0.0089	0.1169	-0.0127	0.0885	75.4915	-39.1296	-86.3431
17	3.4529	-3.3781	0.574	3.3316	-0.5529	0.4335	-0.2418	-0.1837	-0.3194	0.3217	0.1485	0.0696	0.0414	0.0666	0.1796	0.1826	0.0236	0.0003	0.2441	0.032	0.1719	73.2734	-39.971	-75.862
18	0.892	-0.3117	-0.054	0.7066	-0.3763	0.8771	-0.0879	-0.1345	0.1107	0.1102	0.0122	-0.1549	-0.1354	0.1177	0.0416	0.1506	-0.0103	-0.0487	0.1512	-0.0226	0.1585	73.0294	-28.8413	-86.2994
19	6.1293	3.8785	2.3298	3.7445	3.7853	7.4331	0.0075	-0.1068	0.7442	0.0976	-0.1125	0.0698	-0.4162	-0.2202	0.1595	0.2021	-0.0194	-0.0615	0.114	-0.008	0.2719	70.7165	-14.034	-90.2566
20	0.966	0.0283	1.0492	5.0606	-2.2584	2.5481	-0.1803	0.1049	0.3524	0.1053	-0.1667	-0.4237	-0.2214	0.2406	0.2861	0.1354	-0.0636	-0.044	0.2049	0.003	0.2805	80.6485	-19.2289	-92.0939
21	3.3521	1.0173	-0.7981	1.3959	0.9317	1.462	-0.3325	0.3498	0.0372	0.4807	-0.1443	-0.4045	-0.5735	0.6791	-1.5775	0.3213	-0.0236	-0.2491	0.2639	-0.0838	0.4853	87.1375	-31.9378	-73.2783
22	6.5795	-5.0378	1.6951	4.6264	-1.9344	2.2243	0.0422	0.1578	-0.147	-0.3349	-0.0697	0.2357	0.1136	0.1529	0.0426	0.2059	-0.0581	-0.0009	0.1375	0.0197	0.1458	39.3217	-76.8666	-101.4975
23	2.1543	-0.5287	0.6694	4.5794	-2.6218	4.8831	0.0006	-0.0742	0.0644	0.2613	-0.0514	-0.1866	-0.1306	0.1756	0.0294	0.1508	-0.0097	-0.0043	0.1091	-0.0182	0.1402	43.2933	-70.0056	-87.0273
24	1.8224	2.3914	-2.7846	6.7199	-5.8916	5.8128	0.2334	-0.381	-0.191	0.4656	-0.506	-0.3505	-0.262	1.0709	0.3695	0.1953	-0.0096	0.0111	0.2048	0.0019	0.194	49.5144	-77.0378	-86.3154
25	1.2352	0.0457	0.33	0.8846	-0.4767	1.1097	0.0238	-0.0322	-0.1096	-0.0928	0.0139	0.0779	0.1083	-0.0528	-0.0407	0.1881	-0.0365	0.0112	0.1081	0.0104	0.1661	33.9038	-75.3672	-95.9277
26	2.9531	-1.2153	1.3801	2.1484	-1.5391	1.876	0.1937	-0.2817	-0.3938	-0.1424	0.0694	0.3936	0.3723	-0.3709	-0.2128	0.2566	-0.0989	-0.0066	0.18	0.0491	0.2654	24.0074	-79.7534	-93.9577
27	1.5873	-1.1022	0.2768	4.1649	-4.0159	4.4375	0.0063	0.14	0.1922	0.2059	-0.037	-0.1092	-0.2214	0.2144	-0.0003	0.162	-0.0059	-0.0106	0.1159	-0.0207	0.1616	39.2616	-5.8181	-98.2468
28	4.3562	-1.1289	0.1925	1.355	0.2453	2.3424	0.0295	0.3069	0.2355	-0.2049	-0.0851	0.0424	-0.0237	-0.2297	0.0365	0.202	-0.0282	-0.0333	0.1355	0.0139	0.163	27.0337	-13.0256	-106.2115
29	2.6783	-0.6035	-0.6849	1.6826	-0.4499	1.5967	0.0657	0.191	0.1861	-0.1607	0.0162	0.143	-0.0738	-0.2097	-0.0501	0.1779	-0.0038	-0.0224	0.1231	-0.0071	0.1482	30.9615	-7.94	-105.8036
30	1.6166	0.099	-0.1695	0.6335	-0.0921	2.5885	-0.0369	-0.0335	0.3021	0.0036	0.0331	0.1824	-0.154	-0.1477	-0.0028	0.155	0.0249	-0.0164	0.1166	-0.0085	0.2091	27.6291	-6.7323	-94.1055
31	3.4548	1.4281	-0.1019	4.6425	-0.3791	4.5827	-0.0675	-0.2385	0.3662	0.0937	0.1293	-0.1005	-0.2012	0.3055	-0.0938	0.1913	0.0181	-0.0054	0.1395	-0.0693	0.1401	39.0573	-6.2071	-84.5463
32	1.6626	-0.2187	1.9901	0.7507	-0.878	4.9108	-0.0864	-0.2202	0.1521	0.0842	0.057	0.1038	-0.3459	-0.3928	0.0227	0.1789	0.0388	0.0236	0.1369	-0.0548	0.2009	27.6639	-4.162	-85.1494
33	5.7086	-1.7795	2.2311	2.6061	-1.4277	1.5028	0.1523	0.2844	0.0136	-0.117	-0.2087	-0.1499	-0.1159	0.2985	0.0948	0.1909	-0.0047	0.061	0.1522	-0.0164	0.1539	66.1987	-67.1235	-114.8486
34	3.1078	-0.5192	0.3193	3.8833	-0.9915	3.1281	0.0531	-0.2795	-0.0943	0.2785	-0.0681	-0.0697	0.1546	0.026	-0.0232	0.1606	-0.0072	0.0037	0.1519	-0.0027	0.0858	59.4776	-70.2912	-100.0001
35	0.7943	1.3791	-1.3699	2.4328	-2.323	2.4229	0.1677	-0.4501	-0.2511	0.3215	-0.1476	-0.3374	0.0586	0.4001	0.0622	0.2631	0.0078	-0.0859	0.2566	0.0486	0.266	68.4704	-72.9992	-96.7445
36	1.5876	0.3331	0.3079	1.7886	-0.0437	0.7963	0.0449	0.0365	-0.137	-0.0614	0.0015	-0.1473	0.1115	0.1149	-0.0384	0.128	0.0048	0.0128	0.1053	-0.0141	0.1289	60.346	-72.3604	-110.3144
37	5.8451	-1.5114	-0.6361	4.5266	1.8238	6.3221	0.0527	0.4275	0.0228	-0.438	-0.0436	-0.1932	-0.1068	0.0384	-0.0199	0.2128	-0.0019	0.0419	0.1189	-0.0392	0.1297	58.9474	-70.7875	-125.6733
38	1.78	-0.5533	1.83	1.2367	-0.9384	5.5263	0.0574	0.0874	-0.2753	-0.162	-0.0036	-0.0039	0.4325	0.051	-0.0529	0.2159	-0.0006	0.0046	0.0872	-0.0637	0.2015	55.8314	-80.2207	-120.3593
39	3.1685	-0.0734	3.8238	1.604	-1.2695	7.1295	0.006	0.1733	-0.1349	-0.2131	0.0272	0.1439	0.1569	0.1974	-0.0607	0.2146	0.0091	0.0401	0.1333	-0.0112	0.1463	55.252	-39.5236	-137.2926
40	3.0299	-0.3381	0.3816	3.0685	-0.9658	3.173	0.0674	0.1334	0.2532	-0.2141	0.0034	0.2246	-0.289	-0.1633	-0.0868	0.1946	0.0464	-0.0225	0.1238	-0.0094	0.1522	47.4536	-26.1395	-132.3229
41	1.8061	0.1075	0.8952	4.0528	-1.4611	2.8924	0.0185	0.0826	0.0133	-0.3982	0.0664	0.3056	-0.0011	-0.2249	-0.1152	0.1943	0.0224	0.001	0.1725	-0.0233	0.1397	46.5705	-31.5078	-135.6231
42	1.663	-0.4778	0.3433	1.4497	-0.5307	0.2093	0.0071	0.1806	0.0326	-0.2115	-0.0221	-0.0603	-0.0142	0.1277	0.0082	0.2219	0.0069	0.0347	0.1762	0.0246	0.114	60.5725	-31.5784	-136.9818
43	3.8941	-2.482	1.7609	2.1187	-1.3606	3.1481	0.0125	0.321	0.3022	-0.137	-0.1306	-0.3	-0.059	0.305	0.1037	0.1826	-0.0212	0.0706	0.2065	0.0574	0.1714	69.5573	-29.4706	-137.2471
44	1.5914	0.1667	1.0272	3.8155	-3.64	5.4815	0.0784	-0.1897	-0.1754	0.1611	0.0911	0.3144	-0.0834	-0.3152	-0.1819	0.1737	0.0131	0.019	0.1728	-0.0495	0.152	40.6257	-33.8367	-68.3237
45	3.4259	0.1876	0.1481	3.7097	0.0861	2.3117	-0.0211	-0.2486	-0.335	0.1323	0.0321	-0.2026	0.1941	0.0679	0.0133	0.1611	0.0322	0.0197	0.1366	0.0097	0.1489	55.2755	-39.3733	-72.3039
46	4.9492	3.0667	5.7181	3.8454	2.9127	7.0908	0.1005	-0.2212	-1.0016	0.1646	0.2599	-0.5487	0.4121	0.2488	-0.2787	0.2188	0.0358	0.0115	0.2522	0.0579	0.2418	55.3667	-45.1418	-64.4816
47	1.0601	-0.0405	0.0145	1.602	0.0602	0.6112	-0.0041	-0.1634	0.0112	0.1203	-0.0247	0.0138	-0.0642	-0.01	0.0287	0.1691	0.005	-0.0016	0.1639	-0.0227	0.1054	46.6997	-29.0066	-69.2522
48	1.9605	-2.2626	0.6154	3.7673	-1.0575	1.1934	-0.1117	-0.2069	0.1856	0.3965	0.0818	-0.2011	-0.2053	0.0856	0.0337	0.2543	-0.0053	-0.0341	0.1947	-0.0686	0.1299	48.0965	-17.8217	-66.2149
49	7.3182	1.4214	5.8188	9.039	1.1837	4.9039	0.3308	-1.4893	-0.7117	1.8509	0.0994	-0.494	-0.2951	1.1462	-0.4094	0.7262	0.0205	-0.0387	0.8709	0.05	0.3089	57.5096	-30.849	-50.9046
50	5.2737	-4.304	2.0544	4.5986	-1.5815	2.3392	-0.0078	-0.2448	-0.2815	0.2268	0.0932	0.3128	-0.0556	-0.263	-0.0227	0.1489	-0.0567	-0.0399	0.2091	-0.0001	0.2163	9.5311	-50.069	-109.4216
51	2.8796	-2.3448	2.894	6.3838	-2.7635	5.3233	-0.2186	0.3317	0.4638	-0.0852	0.1206	-0.0969	-0.7133	-0.066	0.1681	0.1854	-0.0232	-0.0068	0.2228	0.0124	0.1742	17.8884	-38.3128	-116.2219
52	3.4673	-0.572	3.5785	2.0366	-0.1729	4.2832	-0.0722	0.1758	0.0631	-0.1511	0.0579	-0.1183	-0.4427	-0.0157	0.1958	0.1682	-0.0148	-0.0213	0.2056	0.0123	0.1956	16.9472	-45.8507	-125.406
53	3.6703	1.6588	3.6985	1.7524	2.1633	3.9916	-0.4488	0.4315	0.3274	-0.3173	0.0892	0.194	-0.8292	0.1084	0.462	0.2336	0.0073	-0.0676	0.2578	-0.0111	0.244	9.6241	-38.2315	-123.5783
54	2.4338	-1.0987	0.7077	6.061	4.2718	6.2171	-0.1189	-0.1027	-0.0899	0.4508	0.2323	0.0646	0.5316	0.2267	-0.1845	0.1211	-0.0202	-0.0384	0.1224	0.0205	0.187	19.7253	-48.2144	-108.3324
55	0.1705	-0.0562	0.2924	1.6997	-0.2374	1.0526	0.0583	-0.0361	-0.1116	-0.125	-0.0473	0.2154	0.0536	-0.1687	0.0044	0.1461	-0.0427	-0.0693	0.2057	0.0014	0.2003	10.9789	-53.0217	-120.7342
56	0.7917	-1.2002	-0.2758	3.6532	0.2148	3.3191	0.107	-0.2922	-0.3711	0.2	-0.0821	0.3064	0.2679	-0.2943	-0.0138	0.1741	-0.0811	-0.026	0.1873	0.0242	0.2576	10.9216	-63.304	-107.5879
57	1.768	0.0584	0.6054	3.5256	-2.2337	2.0245	0.2473	-0.0517	-0.3209	-0.3567	0.0118	0.2973	0.4491	-0.1376	-0.144	0.2087	-0.078	-0.0937	0.2068	-0.0103	0.2885	11.7359	-68.0253	-116.0495
58	6.9598	1.4498	-1.7661	5.581	2.0667	4.2238	0.1702	0.8255	-0.1816	-0.8107	0.0709	0.6107	0.1492	-0.6834	0.0928	0.2363	-0.0813	-0.1336	0.2716	0.0222	0.3188	5.5666	-56.3911	-125.9131
59	6.1989	-0.9312	2.7372	0.28	-0.9391	3.7896	0.1337	0.1532	-0.3282	-0.0959	0.0363	0.1716	0.2594	-0.1891	-0.1546	0.234	-0.0256	-0.0405	0.167	-0.0431	0.1621	30.4766	-58.2038	-132.0239
60	3.1382	-0.1507	-0.1527	2.6991	-0.4219	3.3913	0.0244	0.2422	0.357	-0.28	0.0437	0.1181	-0.1839	-0.2208	-0.0077	0.1851	0.0074	-0.0363	0.1379	0.0085	0.1833	34.2954	-41.9459	-134.8033
61	2.2814	0.0405	-0.4102	1.4732	-0.8432	4.174	0.0721	0.1823	0.1396	-0.1571	0.0881	0.3123	-0.1648	-0.4236	-0.1684	0.1869	-0.013	-0.0603	0.1758	-0.0093	0.2	29.2136	-45.7871	-133.3735
62	0.7593	-0.6294	-0.4344	1.5383	-0.2626	0.6314	0.027	0.1725	-0.0883	-0.3065	0.0065	0.1131	0.1047	-0.129	-0.0371	0.2691	-0.019	-0.0588	0.208	-0.0447	0.1351	37.3682	-56.2237	-138.2223
63	1.6613	-1.7337	0.8586	4.1631	-1.2324	1.0487	0.2181	0.3505	-0.121	-0.5864	-0.2012	0.0528	0.113	0.0534	-0.0368	0.3319	-0.0118	-0.0019	0.2165	-0.0603	0.1274	43.5629	-61.2403	-142.6894
64	0.9355	-2.0752	1.6034	6.454	-3.4196	4.524	0.0755	0.0671	-0.1669	0.0233	0.0677	0.2401	0.3088	-0.2398	-0.1371	0.176	-0.0525	0.0391	0.1963	0.0026	0.1431	26.6726	-60.1589	-78.1832
65	7.7162	-4.2023	5.6406	3.7394	-5.4076	8.118	0.3101	0.0174	-0.3091	-0.0923	-0.2624	-0.0972	0.3877	0.6954	0.0738	0.2258	0.0194	0.0303	0.2372	-0.0191	0.2145	42.1827	-59.0871	-80.2757
66	4.7011	-1.0411	1.7546	6.1884	-4.0665	3.0397	0.0422	-0.3246	0.0208	0.3627	-0.0451	-0.1539	-0.2686	0.1594	0.0377	0.1231	-0.0023	0.0052	0.1263	-0.0257	0.1608	41.166	-52.4324	-70.2398
67	1.5683	-0.5502	0.8316	2.1142	-0.684	5.8943	0.0226	-0.0933	-0.1376	0.1811	0.0176	-0.0448	0.3877	0.223	-0.0505	0.1761	-0.0013	0.024	0.1349	0.018	0.1562	37.3327	-59.4881	-73.5824
68	6.5921	-3.1415	-2.0425	4.5926	1.3744	1.3939	-0.3088	-0.3562	-0.442	0.5417	0.2224	0.1952	0.1207	-0.1915	0.0582	0.3065	-0.0766	0.0478	0.2775	0.06	0.1776	24.6327	-61.4634	-67.3221
69	2.8004	-0.5964	0.3749	1.3791	0.3173	1.3167	-0.0774	-0.0215	-0.0038	0.0745	0.0393	0.0819	-0.0276	-0.2647	0.0461	0.1751	-0.0142	0.0508	0.2025	0.02	0.0974	24.2768	-48.033	-73.5399
70	5.8128	-2.4707	2.4336	1.6425	-1.4338	3.0371	-0.1465	-0.4887	0.0158	0.2844	0.1769	0.2115	-0.0849	-0.3269	-0.025	0.1879	0.0078	0.0826	0.248	-0.0177	0.1519	17.217	-45.9833	-69.0375
71	6.4482	-0.1872	-0.4585	4.0022	1.7391	4.1664	0.1934	-0.7654	-0.3289	1.0196	0.1075	0.3049	0.1094	-0.24	-0.1418	0.3483	-0.0067	0.0815	0.3171	0.0627	0.1498	28.5888	-55.2107	-60.8865
72	1.4112	-1.8726	2.2085	2.7967	-1.6836	7.7349	0.1277	0.1722	-0.0167	-0.1047	-0.183	-0.2369	-0.2186	0.2726	0.019	0.1363	-0.0084	0.0051	0.1254	0.0417	0.2287	60.1538	-13.6317	-120.4077
73	2.1789	-0.3381	0.461	3.5228	-1.4099	2.3008	0.0634	0.1898	-0.0984	-0.0077	-0.0883	0.2592	-0.1182	-0.0776	-0.0218	0.1267	0.0129	-0.0037	0.1322	-0.0042	0.103	43.6877	-11.0115	-118.5926
74	3.7477	-5.1978	-0.914	8.5067	0.5467	0.6243	0.3377	0.5566	-0.0888	-0.4973	-0.502	0.3222	-0.0465	-0.0179	0.1488	0.2481	0.0222	-0.0196	0.1769	0.0058	0.1739	43.8756	-8.8296	-127.258
75	1.0224	-0.2614	0.2372	1.2739	0.0164	0.9271	-0.001	0.0691	0.1416	-0.0284	-0.0532	-0.1529	-0.0477	0.0823	0.0477	0.1713	-0.015	0.0068	0.1133	0.0367	0.1896	57.0393	-9.1315	-114.5282
76	3.5335	-0.5834	2.7282	1.4017	-1.1874	3.1605	-0.1496	0.1036	0.3312	0.1672	-0.1134	-0.2967	-0.2659	0.209	0.2507	0.2233	-0.0597	-0.0273	0.1082	0.0092	0.2757	62.038	-1.0403	-107.9827
77	3.6641	-0.4568	0.8923	1.4188	1.9004	3.1879	-0.2473	1.0995	0.7099	-0.277	-0.4111	-0.5232	-1.1296	0.5217	0.3404	0.427	-0.0214	0.0088	0.3561	0.2094	0.5353	53.0459	8.2437	-125.9997

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	chain 'A' and (resid 754 through 785 )	A	754 - 785
2	X-RAY DIFFRACTION	2	chain 'A' and (resid 786 through 807 )	A	786 - 807
3	X-RAY DIFFRACTION	3	chain 'A' and (resid 808 through 828 )	A	808 - 828
4	X-RAY DIFFRACTION	4	chain 'A' and (resid 829 through 843 )	A	829 - 843
5	X-RAY DIFFRACTION	5	chain 'A' and (resid 844 through 894 )	A	844 - 894
6	X-RAY DIFFRACTION	6	chain 'A' and (resid 895 through 908 )	A	895 - 908
7	X-RAY DIFFRACTION	7	chain 'A' and (resid 909 through 948 )	A	909 - 948
8	X-RAY DIFFRACTION	8	chain 'B' and (resid 754 through 785 )	B	754 - 785
9	X-RAY DIFFRACTION	9	chain 'B' and (resid 786 through 828 )	B	786 - 828
10	X-RAY DIFFRACTION	10	chain 'B' and (resid 829 through 843 )	B	829 - 843
11	X-RAY DIFFRACTION	11	chain 'B' and (resid 844 through 894 )	B	844 - 894
12	X-RAY DIFFRACTION	12	chain 'B' and (resid 895 through 908 )	B	895 - 908
13	X-RAY DIFFRACTION	13	chain 'B' and (resid 909 through 948 )	B	909 - 948
14	X-RAY DIFFRACTION	14	chain 'C' and (resid 755 through 785 )	C	755 - 785
15	X-RAY DIFFRACTION	15	chain 'C' and (resid 786 through 807 )	C	786 - 807
16	X-RAY DIFFRACTION	16	chain 'C' and (resid 808 through 828 )	C	808 - 828
17	X-RAY DIFFRACTION	17	chain 'C' and (resid 829 through 844 )	C	829 - 844
18	X-RAY DIFFRACTION	18	chain 'C' and (resid 845 through 894 )	C	845 - 894
19	X-RAY DIFFRACTION	19	chain 'C' and (resid 895 through 908 )	C	895 - 908
20	X-RAY DIFFRACTION	20	chain 'C' and (resid 909 through 946 )	C	909 - 946
21	X-RAY DIFFRACTION	21	chain 'C' and (resid 947 through 957 )	C	947 - 957
22	X-RAY DIFFRACTION	22	chain 'D' and (resid 755 through 785 )	D	755 - 785
23	X-RAY DIFFRACTION	23	chain 'D' and (resid 786 through 828 )	D	786 - 828
24	X-RAY DIFFRACTION	24	chain 'D' and (resid 829 through 844 )	D	829 - 844
25	X-RAY DIFFRACTION	25	chain 'D' and (resid 845 through 908 )	D	845 - 908
26	X-RAY DIFFRACTION	26	chain 'D' and (resid 909 through 949 )	D	909 - 949
27	X-RAY DIFFRACTION	27	chain 'E' and (resid 755 through 785 )	E	755 - 785
28	X-RAY DIFFRACTION	28	chain 'E' and (resid 786 through 828 )	E	786 - 828
29	X-RAY DIFFRACTION	29	chain 'E' and (resid 829 through 869 )	E	829 - 869
30	X-RAY DIFFRACTION	30	chain 'E' and (resid 870 through 894 )	E	870 - 894
31	X-RAY DIFFRACTION	31	chain 'E' and (resid 895 through 908 )	E	895 - 908
32	X-RAY DIFFRACTION	32	chain 'E' and (resid 909 through 949 )	E	909 - 949
33	X-RAY DIFFRACTION	33	chain 'F' and (resid 754 through 785 )	F	754 - 785
34	X-RAY DIFFRACTION	34	chain 'F' and (resid 786 through 828 )	F	786 - 828
35	X-RAY DIFFRACTION	35	chain 'F' and (resid 829 through 843 )	F	829 - 843
36	X-RAY DIFFRACTION	36	chain 'F' and (resid 844 through 894 )	F	844 - 894
37	X-RAY DIFFRACTION	37	chain 'F' and (resid 895 through 908 )	F	895 - 908
38	X-RAY DIFFRACTION	38	chain 'F' and (resid 909 through 948 )	F	909 - 948
39	X-RAY DIFFRACTION	39	chain 'G' and (resid 755 through 785 )	G	755 - 785
40	X-RAY DIFFRACTION	40	chain 'G' and (resid 786 through 828 )	G	786 - 828
41	X-RAY DIFFRACTION	41	chain 'G' and (resid 829 through 856 )	G	829 - 856
42	X-RAY DIFFRACTION	42	chain 'G' and (resid 857 through 908 )	G	857 - 908
43	X-RAY DIFFRACTION	43	chain 'G' and (resid 909 through 948 )	G	909 - 948
44	X-RAY DIFFRACTION	44	chain 'H' and (resid 755 through 785 )	H	755 - 785
45	X-RAY DIFFRACTION	45	chain 'H' and (resid 786 through 828 )	H	786 - 828
46	X-RAY DIFFRACTION	46	chain 'H' and (resid 829 through 843 )	H	829 - 843
47	X-RAY DIFFRACTION	47	chain 'H' and (resid 844 through 908 )	H	844 - 908
48	X-RAY DIFFRACTION	48	chain 'H' and (resid 909 through 946 )	H	909 - 946
49	X-RAY DIFFRACTION	49	chain 'H' and (resid 947 through 957 )	H	947 - 957
50	X-RAY DIFFRACTION	50	chain 'I' and (resid 754 through 785 )	I	754 - 785
51	X-RAY DIFFRACTION	51	chain 'I' and (resid 786 through 807 )	I	786 - 807
52	X-RAY DIFFRACTION	52	chain 'I' and (resid 808 through 828 )	I	808 - 828
53	X-RAY DIFFRACTION	53	chain 'I' and (resid 829 through 844 )	I	829 - 844
54	X-RAY DIFFRACTION	54	chain 'I' and (resid 845 through 856 )	I	845 - 856
55	X-RAY DIFFRACTION	55	chain 'I' and (resid 857 through 894 )	I	857 - 894
56	X-RAY DIFFRACTION	56	chain 'I' and (resid 895 through 908 )	I	895 - 908
57	X-RAY DIFFRACTION	57	chain 'I' and (resid 909 through 938 )	I	909 - 938
58	X-RAY DIFFRACTION	58	chain 'I' and (resid 939 through 949 )	I	939 - 949
59	X-RAY DIFFRACTION	59	chain 'J' and (resid 754 through 785 )	J	754 - 785
60	X-RAY DIFFRACTION	60	chain 'J' and (resid 786 through 828 )	J	786 - 828
61	X-RAY DIFFRACTION	61	chain 'J' and (resid 829 through 856 )	J	829 - 856
62	X-RAY DIFFRACTION	62	chain 'J' and (resid 857 through 908 )	J	857 - 908
63	X-RAY DIFFRACTION	63	chain 'J' and (resid 909 through 949 )	J	909 - 949
64	X-RAY DIFFRACTION	64	chain 'K' and (resid 754 through 785 )	K	754 - 785
65	X-RAY DIFFRACTION	65	chain 'K' and (resid 786 through 807 )	K	786 - 807
66	X-RAY DIFFRACTION	66	chain 'K' and (resid 808 through 828 )	K	808 - 828
67	X-RAY DIFFRACTION	67	chain 'K' and (resid 829 through 869 )	K	829 - 869
68	X-RAY DIFFRACTION	68	chain 'K' and (resid 870 through 879 )	K	870 - 879
69	X-RAY DIFFRACTION	69	chain 'K' and (resid 880 through 908 )	K	880 - 908
70	X-RAY DIFFRACTION	70	chain 'K' and (resid 909 through 938 )	K	909 - 938
71	X-RAY DIFFRACTION	71	chain 'K' and (resid 939 through 949 )	K	939 - 949
72	X-RAY DIFFRACTION	72	chain 'L' and (resid 754 through 785 )	L	754 - 785
73	X-RAY DIFFRACTION	73	chain 'L' and (resid 786 through 828 )	L	786 - 828
74	X-RAY DIFFRACTION	74	chain 'L' and (resid 829 through 844 )	L	829 - 844
75	X-RAY DIFFRACTION	75	chain 'L' and (resid 845 through 908 )	L	845 - 908
76	X-RAY DIFFRACTION	76	chain 'L' and (resid 909 through 946 )	L	909 - 946
77	X-RAY DIFFRACTION	77	chain 'L' and (resid 947 through 956 )	L	947 - 956