Entry Database : PDB / ID : 6war Structure visualization Downloads & linksTitle Crystal structure of the MERS-CoV RBD bound by the neutralizing single-domain antibody MERS VHH-55 ComponentsSpike protein nanobody MERS VHH-55 DetailsKeywords VIRAL PROTEIN/IMMUNE SYSTEM / MERS-CoV / nanobody / coronavirus / RBD / VIRAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM complexFunction / homology Function and homology informationFunction Domain/homology Component
endocytosis involved in viral entry into host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / membrane fusion / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / host cell plasma membrane / virion membrane / membrane Similarity search - Function ubp-family deubiquitinating enzyme fold - #30 / Spike protein, C-terminal core receptor binding subdomain / ubp-family deubiquitinating enzyme fold / Spike (S) protein S1 subunit, receptor-binding domain, MERS-CoV / Spike (S) protein S1 subunit, N-terminal domain, MERS-CoV-like / Spike glycoprotein S2, coronavirus, C-terminal / Coronavirus spike glycoprotein S2, intravirion / Single Sheet / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily ... ubp-family deubiquitinating enzyme fold - #30 / Spike protein, C-terminal core receptor binding subdomain / ubp-family deubiquitinating enzyme fold / Spike (S) protein S1 subunit, receptor-binding domain, MERS-CoV / Spike (S) protein S1 subunit, N-terminal domain, MERS-CoV-like / Spike glycoprotein S2, coronavirus, C-terminal / Coronavirus spike glycoprotein S2, intravirion / Single Sheet / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal / Alpha-Beta Plaits / 2-Layer Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species Middle East respiratory syndrome-related coronavirusLama glama (llama)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.4 Å DetailsAuthors Wrapp, D. / Torres, G.M. / McLellan, J.S. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) R01-AI127521 United States
CitationJournal : Cell / Year : 2020Title : Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.Authors: Wrapp, D. / De Vlieger, D. / Corbett, K.S. / Torres, G.M. / Wang, N. / Van Breedam, W. / Roose, K. / van Schie, L. / Hoffmann, M. / Pohlmann, S. / Graham, B.S. / Callewaert, N. / Schepens, B. ... Authors : Wrapp, D. / De Vlieger, D. / Corbett, K.S. / Torres, G.M. / Wang, N. / Van Breedam, W. / Roose, K. / van Schie, L. / Hoffmann, M. / Pohlmann, S. / Graham, B.S. / Callewaert, N. / Schepens, B. / Saelens, X. / McLellan, J.S. History Deposition Mar 25, 2020 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 8, 2020 Provider : repository / Type : Initial releaseRevision 1.1 May 20, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.journal_abbrev / _citation.journal_id_CSD ... _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Jun 10, 2020 Group : Advisory / Database references / Derived calculationsCategory : citation / pdbx_validate_close_contact / struct_connItem : _citation.journal_volume / _citation.page_firstRevision 1.3 Jul 29, 2020 Group : Data collection / Derived calculations / Structure summaryCategory : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item : _chem_comp.name / _entity.pdbx_description ... _chem_comp.name / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 1.4 Oct 18, 2023 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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