登録情報 データベース : PDB / ID : 6vwu 構造の表示 ダウンロードとリンクタイトル X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2 Receptor alpha 要素Interleukin-2,Interleukin-2 receptor subunit alpha 詳細 キーワード CYTOKINE / circular permutation / ALKS 4230機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of T cell tolerance induction / interleukin-2 receptor complex / interleukin-2 receptor activity / interleukin-2 binding / kappa-type opioid receptor binding / regulation of T cell homeostatic proliferation / regulation of CD4-positive, alpha-beta T cell proliferation / interleukin-2 receptor binding / glycosphingolipid binding / negative regulation of lymphocyte proliferation ... regulation of T cell tolerance induction / interleukin-2 receptor complex / interleukin-2 receptor activity / interleukin-2 binding / kappa-type opioid receptor binding / regulation of T cell homeostatic proliferation / regulation of CD4-positive, alpha-beta T cell proliferation / interleukin-2 receptor binding / glycosphingolipid binding / negative regulation of lymphocyte proliferation / positive regulation of plasma cell differentiation / response to tacrolimus / negative regulation of T-helper 17 cell differentiation / positive regulation of tissue remodeling / RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) / leukocyte activation involved in immune response / positive regulation of isotype switching to IgG isotypes / interleukin-2-mediated signaling pathway / activated T cell proliferation / inflammatory response to antigenic stimulus / cell surface receptor signaling pathway via STAT / kinase activator activity / natural killer cell activation / Interleukin-2 signaling / activation-induced cell death of T cells / positive regulation of regulatory T cell differentiation / positive regulation of T cell differentiation / negative regulation of B cell apoptotic process / positive regulation of immunoglobulin production / positive regulation of dendritic spine development / positive regulation of interleukin-17 production / positive regulation of activated T cell proliferation / T cell differentiation / Interleukin receptor SHC signaling / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of T cell proliferation / Notch signaling pathway / positive regulation of B cell proliferation / cytokine activity / growth factor activity / negative regulation of inflammatory response / positive regulation of type II interferon production / positive regulation of inflammatory response / cell-cell signaling / positive regulation of cytosolic calcium ion concentration / RAF/MAP kinase cascade / carbohydrate binding / positive regulation of cell growth / phospholipase C-activating G protein-coupled receptor signaling pathway / adaptive immune response / response to ethanol / transcription by RNA polymerase II / cell surface receptor signaling pathway / cell adhesion / immune response / inflammatory response / external side of plasma membrane / apoptotic process / positive regulation of cell population proliferation / negative regulation of apoptotic process / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / plasma membrane 類似検索 - 分子機能 Interleukin-2 receptor alpha / Interleukin-2 / Interleukin-2, conserved site / Interleukin 2 / Interleukin-2 signature. / Interleukin-2 family / Sushi repeat (SCR repeat) / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Four-helical cytokine-like, core / Sushi/SCR/CCP domain ... Interleukin-2 receptor alpha / Interleukin-2 / Interleukin-2, conserved site / Interleukin 2 / Interleukin-2 signature. / Interleukin-2 family / Sushi repeat (SCR repeat) / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Four-helical cytokine-like, core / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily 類似検索 - ドメイン・相同性 Interleukin-2 receptor subunit alpha / Interleukin-2 / Interleukin-2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.4 Å 詳細データ登録者 Losey, H.C. 引用ジャーナル : J Immunother Cancer / 年 : 2020タイトル : ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy.著者 : Lopes, J.E. / Fisher, J.L. / Flick, H.L. / Wang, C. / Sun, L. / Ernstoff, M.S. / Alvarez, J.C. / Losey, H.C. 履歴 登録 2020年2月20日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2020年4月29日 Provider : repository / タイプ : Initial release改定 1.1 2020年5月6日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_id_ISSN / _citation.journal_volume ... _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name 改定 1.2 2023年10月11日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_initial_refinement_model Item : _citation.country / _database_2.pdbx_DOI / _database_2.pdbx_database_accession改定 1.3 2024年11月20日 Group : Structure summaryカテゴリ : pdbx_entry_details / pdbx_modification_feature
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