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TitleALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy.
Journal, issue, pagesJ Immunother Cancer, Vol. 8, Year 2020
Publish dateFeb 20, 2020 (structure data deposition date)
AuthorsLopes, J.E. / Fisher, J.L. / Flick, H.L. / Wang, C. / Sun, L. / Ernstoff, M.S. / Alvarez, J.C. / Losey, H.C.
External linksJ Immunother Cancer / PubMed:32317293
MethodsX-ray diffraction
Resolution3.4 Å
Structure data

PDB-6vwu:
X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2 Receptor alpha
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Source
  • homo sapiens (human)
KeywordsCYTOKINE / circular permutation / ALKS 4230

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