登録情報 データベース : PDB / ID : 6ved 構造の表示 ダウンロードとリンクタイトル Solution structure of the TTD and linker region of UHRF1 要素E3 ubiquitin-protein ligase UHRF1 詳細 キーワード PEPTIDE BINDING PROTEIN / Histone / Tandem Tudor Domain / UHRF1 / H3K9me3機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
histone H3 ubiquitin ligase activity / H3K9me3 modified histone binding / positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity / DNA damage sensor activity / hemi-methylated DNA-binding / homologous recombination / regulation of epithelial cell proliferation / methyl-CpG binding / negative regulation of gene expression via chromosomal CpG island methylation / mitotic spindle assembly ... histone H3 ubiquitin ligase activity / H3K9me3 modified histone binding / positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity / DNA damage sensor activity / hemi-methylated DNA-binding / homologous recombination / regulation of epithelial cell proliferation / methyl-CpG binding / negative regulation of gene expression via chromosomal CpG island methylation / mitotic spindle assembly / protein autoubiquitination / cis-regulatory region sequence-specific DNA binding / heterochromatin / heterochromatin formation / epigenetic regulation of gene expression / methylated histone binding / positive regulation of protein metabolic process / DNA methylation / Chromatin modifications during the maternal to zygotic transition (MZT) / replication fork / double-strand break repair via homologous recombination / euchromatin / RING-type E3 ubiquitin transferase / nuclear matrix / spindle / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / histone binding / ubiquitin-dependent protein catabolic process / nucleic acid binding / protein ubiquitination / DNA damage response / chromatin / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / identical protein binding / nucleus 類似検索 - 分子機能 : / UHRF1, tandem tudor domain / UHRF1/2-like / Tandem tudor domain within UHRF1 / SRA-YDG / SRA-YDG superfamily / SAD/SRA domain / YDG domain profile. / SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. / SH3 type barrels. - #30 ... : / UHRF1, tandem tudor domain / UHRF1/2-like / Tandem tudor domain within UHRF1 / SRA-YDG / SRA-YDG superfamily / SAD/SRA domain / YDG domain profile. / SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. / SH3 type barrels. - #30 / SH3 type barrels. - #140 / PUA-like superfamily / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / PHD-finger / Ring finger / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, FYVE/PHD-type / SH3 type barrels. / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Zinc finger, RING/FYVE/PHD-type / Ubiquitin-like domain superfamily / Roll / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 溶液NMR / molecular dynamics 詳細データ登録者 Lemak, A. / Houliston, S. / Duan, S. / Ong, M.S. / Arrowsmith, C.H. 資金援助 カナダ, 1件 詳細 詳細を隠す組織 認可番号 国 Natural Sciences and Engineering Research Council (NSERC, Canada) RGPIN-2015-05939 カナダ
引用ジャーナル : Nucleic Acids Res. / 年 : 2020タイトル : Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1.著者: Tauber, M. / Kreuz, S. / Lemak, A. / Mandal, P. / Yerkesh, Z. / Veluchamy, A. / Al-Gashgari, B. / Aljahani, A. / Cortes-Medina, L.V. / Azhibek, D. / Fan, L. / Ong, M.S. / Duan, S. / ... 著者 : Tauber, M. / Kreuz, S. / Lemak, A. / Mandal, P. / Yerkesh, Z. / Veluchamy, A. / Al-Gashgari, B. / Aljahani, A. / Cortes-Medina, L.V. / Azhibek, D. / Fan, L. / Ong, M.S. / Duan, S. / Houliston, S. / Arrowsmith, C.H. / Fischle, W. 履歴 登録 2019年12月31日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2020年6月17日 Provider : repository / タイプ : Initial release改定 1.1 2020年7月15日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title改定 1.2 2020年8月26日 Group : Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.3 2023年6月14日 Group : Database references / Other / カテゴリ : database_2 / pdbx_database_statusItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data改定 1.4 2024年5月15日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2 / Item : _database_2.pdbx_DOI
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