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Yorodumi- PDB-3coj: Crystal Structure of the BRCT Domains of Human BRCA1 in Complex w... -
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-Basic information
Entry | Database: PDB / ID: 3coj | ||||||
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Title | Crystal Structure of the BRCT Domains of Human BRCA1 in Complex with a Phosphorylated Peptide from Human Acetyl-CoA Carboxylase 1 | ||||||
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Keywords | ANTITUMOR PROTEIN/LIGASE / Breast Cancer / Ovarian Cancer / Fatty Acid Biosynthesis / lipid synthesis / Obesity / Protein-peptide complex / Protein Protein interaction / Anti-oncogene / Cell cycle / Disease mutation / DNA damage / DNA repair / DNA-binding / Metal-binding / Nucleus / Phosphoprotein / Zinc-finger / Alternative promoter usage / ATP-binding / Biotin / Ligase / Manganese / Multifunctional enzyme / Nucleotide-binding / ANTITUMOR PROTEIN-LIGASE COMPLEX | ||||||
Function / homology | Function and homology information fatty-acyl-CoA biosynthetic process / Defective DNA double strand break response due to BRCA1 loss of function / Defective DNA double strand break response due to BARD1 loss of function / BRCA1-BARD1 complex / Defective HLCS causes multiple carboxylase deficiency / acetyl-CoA carboxylase / BRCA1-C complex / BRCA1-B complex / Biotin transport and metabolism / BRCA1-A complex ...fatty-acyl-CoA biosynthetic process / Defective DNA double strand break response due to BRCA1 loss of function / Defective DNA double strand break response due to BARD1 loss of function / BRCA1-BARD1 complex / Defective HLCS causes multiple carboxylase deficiency / acetyl-CoA carboxylase / BRCA1-C complex / BRCA1-B complex / Biotin transport and metabolism / BRCA1-A complex / random inactivation of X chromosome / negative regulation of centriole replication / sex-chromosome dosage compensation / Fatty acyl-CoA biosynthesis / acetyl-CoA metabolic process / negative regulation of intracellular estrogen receptor signaling pathway / gamma-tubulin ring complex / malonyl-CoA biosynthetic process / nuclear ubiquitin ligase complex / ChREBP activates metabolic gene expression / acetyl-CoA carboxylase activity / chordate embryonic development / cellular response to indole-3-methanol / negative regulation of fatty acid biosynthetic process / lateral element / homologous recombination / DNA strand resection involved in replication fork processing / tissue homeostasis / protein K6-linked ubiquitination / regulation of DNA damage checkpoint / Carnitine metabolism / Impaired BRCA2 binding to PALB2 / protein metabolic process / XY body / lipid homeostasis / mitotic G2/M transition checkpoint / postreplication repair / DNA repair complex / RNA polymerase binding / centrosome cycle / Defective homologous recombination repair (HRR) due to BRCA1 loss of function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function / Homologous DNA Pairing and Strand Exchange / Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) / Resolution of D-loop Structures through Holliday Junction Intermediates / intracellular non-membrane-bounded organelle / HDR through Single Strand Annealing (SSA) / negative regulation of gene expression via chromosomal CpG island methylation / Impaired BRCA2 binding to RAD51 / DNA-binding transcription activator activity / response to ionizing radiation / Transcriptional Regulation by E2F6 / mitotic G2 DNA damage checkpoint signaling / Presynaptic phase of homologous DNA pairing and strand exchange / negative regulation of cell cycle / positive regulation of vascular endothelial growth factor production / negative regulation of reactive oxygen species metabolic process / positive regulation of DNA repair / protein autoubiquitination / male germ cell nucleus / SUMOylation of DNA damage response and repair proteins / regulation of DNA repair / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / ubiquitin ligase complex / Meiotic synapsis / tubulin binding / Activation of gene expression by SREBF (SREBP) / Meiotic recombination / Nonhomologous End-Joining (NHEJ) / chromosome segregation / cellular response to ionizing radiation / TP53 Regulates Transcription of DNA Repair Genes / G2/M DNA damage checkpoint / double-strand break repair via homologous recombination / RING-type E3 ubiquitin transferase / HDR through Homologous Recombination (HRR) / negative regulation of cell growth / p53 binding / Metalloprotease DUBs / fibrillar center / fatty acid biosynthetic process / cellular response to prostaglandin E stimulus / positive regulation of angiogenesis / ubiquitin-protein transferase activity / chromosome / intrinsic apoptotic signaling pathway in response to DNA damage / KEAP1-NFE2L2 pathway / double-strand break repair / actin cytoskeleton / Processing of DNA double-strand break ends / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / cellular response to tumor necrosis factor / Neddylation / Regulation of TP53 Activity through Phosphorylation / protein homotetramerization / transcription coactivator activity / transcription cis-regulatory region binding / damaged DNA binding / nuclear body Similarity search - Function | ||||||
Biological species | Homo sapiens (human) synthetic construct (others) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.21 Å | ||||||
Authors | Shen, Y. / Tong, L. | ||||||
Citation | Journal: Biochemistry / Year: 2008 Title: Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1 Authors: Shen, Y. / Tong, L. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 3coj.cif.gz | 337.5 KB | Display | PDBx/mmCIF format |
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PDB format | pdb3coj.ent.gz | 275.6 KB | Display | PDB format |
PDBx/mmJSON format | 3coj.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 3coj_validation.pdf.gz | 565 KB | Display | wwPDB validaton report |
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Full document | 3coj_full_validation.pdf.gz | 617.2 KB | Display | |
Data in XML | 3coj_validation.xml.gz | 60.3 KB | Display | |
Data in CIF | 3coj_validation.cif.gz | 81.8 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/co/3coj ftp://data.pdbj.org/pub/pdb/validation_reports/co/3coj | HTTPS FTP |
-Related structure data
Related structure data | 1jnxS S: Starting model for refinement |
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Similar structure data |
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-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: 1 / Refine code: 4
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