Entry | Database: PDB / ID: 6txd |
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Title | Variant W229D/F290W-12 of the last common ancestor of Gram-negative bacteria beta-lactamase class A (GNCA4) |
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Components | Beta lactamase (GNCA4-12) |
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Keywords | HYDROLASE / ANTIBIOTIC RESISTANCE / ANCESTRAL RECONSTRUCTED |
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Function / homology | ACETATE ION / FORMIC ACID Function and homology information |
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Biological species | synthetic construct (others) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2 Å |
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Authors | Gavira, J.A. / Risso, V. / Sanchez-Ruiz, J.M. / Romero-Rivera, A. / Kamerlin, S.C.L. |
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Funding support | Spain, United States, 3items Organization | Grant number | Country |
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Spanish Ministry of Science, Innovation, and Universities | BIO2016-74875-P | Spain | Spanish Ministry of Economy and Competitiveness | BIO2015-66426-R | Spain | Human Frontier Science Program (HFSP) | RGP0041/2017 | United States |
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Citation | Journal: Chem Sci / Year: 2020 Title: Enhancing ade novoenzyme activity by computationally-focused ultra-low-throughput screening. Authors: Risso, V.A. / Romero-Rivera, A. / Gutierrez-Rus, L.I. / Ortega-Munoz, M. / Santoyo-Gonzalez, F. / Gavira, J.A. / Sanchez-Ruiz, J.M. / Kamerlin, S.C.L. |
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History | Deposition | Jan 14, 2020 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jun 3, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Sep 16, 2020 | Group: Database references / Derived calculations Category: citation / citation_author ...citation / citation_author / pdbx_struct_conn_angle / struct_conn Item: _citation.journal_id_ISSN / _citation.journal_volume ..._citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_seq_id |
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Revision 1.2 | Jan 24, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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