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Yorodumi- PDB-6tpj: Crystal structure of the Orexin-2 receptor in complex with suvore... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6tpj | ||||||
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Title | Crystal structure of the Orexin-2 receptor in complex with suvorexant at 2.76 A resolution | ||||||
Components | Orexin receptor type 2,GlgA glycogen synthase,Hypocretin receptor-2 | ||||||
Keywords | MEMBRANE PROTEIN / 7TM / GPCR | ||||||
Function / homology | Function and homology information regulation of circadian sleep/wake cycle, wakefulness / circadian sleep/wake cycle process / orexin receptor activity / Orexin and neuropeptides FF and QRFP bind to their respective receptors / neuropeptide receptor activity / glycogen (starch) synthase activity / feeding behavior / locomotion / glycogen biosynthetic process / peptide hormone binding ...regulation of circadian sleep/wake cycle, wakefulness / circadian sleep/wake cycle process / orexin receptor activity / Orexin and neuropeptides FF and QRFP bind to their respective receptors / neuropeptide receptor activity / glycogen (starch) synthase activity / feeding behavior / locomotion / glycogen biosynthetic process / peptide hormone binding / neuropeptide signaling pathway / cellular response to hormone stimulus / regulation of cytosolic calcium ion concentration / peptide binding / phospholipase C-activating G protein-coupled receptor signaling pathway / G alpha (q) signalling events / chemical synaptic transmission / synapse / plasma membrane / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) Pyrococcus abyssi GE5 (archaea) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.74 Å | ||||||
Authors | Rappas, M. / Ali, A. / Bennett, K.A. / Brown, J.D. / Bucknell, S.J. / Congreve, M. / Cooke, R.M. / Cseke, G. / de Graaf, C. / Dore, A.S. ...Rappas, M. / Ali, A. / Bennett, K.A. / Brown, J.D. / Bucknell, S.J. / Congreve, M. / Cooke, R.M. / Cseke, G. / de Graaf, C. / Dore, A.S. / Errey, J.C. / Jazayeri, A. / Marshall, F.H. / Mason, J.S. / Mould, R. / Patel, J.C. / Tehan, B.G. / Weir, M. / Christopher, J.A. | ||||||
Funding support | United States, 1items
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Citation | Journal: J.Med.Chem. / Year: 2020 Title: Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis. Authors: Rappas, M. / Ali, A.A.E. / Bennett, K.A. / Brown, J.D. / Bucknell, S.J. / Congreve, M. / Cooke, R.M. / Cseke, G. / de Graaf, C. / Dore, A.S. / Errey, J.C. / Jazayeri, A. / Marshall, F.H. / ...Authors: Rappas, M. / Ali, A.A.E. / Bennett, K.A. / Brown, J.D. / Bucknell, S.J. / Congreve, M. / Cooke, R.M. / Cseke, G. / de Graaf, C. / Dore, A.S. / Errey, J.C. / Jazayeri, A. / Marshall, F.H. / Mason, J.S. / Mould, R. / Patel, J.C. / Tehan, B.G. / Weir, M. / Christopher, J.A. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6tpj.cif.gz | 434.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6tpj.ent.gz | 351.2 KB | Display | PDB format |
PDBx/mmJSON format | 6tpj.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6tpj_validation.pdf.gz | 4.6 MB | Display | wwPDB validaton report |
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Full document | 6tpj_full_validation.pdf.gz | 4.4 MB | Display | |
Data in XML | 6tpj_validation.xml.gz | 43.4 KB | Display | |
Data in CIF | 6tpj_validation.cif.gz | 59.3 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/tp/6tpj ftp://data.pdbj.org/pub/pdb/validation_reports/tp/6tpj | HTTPS FTP |
-Related structure data
Related structure data | 6to7C 6todC 6tosC 6totC 6tp3C 6tp4C 6tp6C 6tpgC 6tpnC 6tq4C 6tq6C 6tq7C 6tq9C 5wqcS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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