Crystal structure of KANK2 ankyrin repeats mutant (A670V)
Components
KN motif and ankyrin repeat domain-containing protein 2
Keywords
CELL ADHESION / Protein binding / ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 25 / MATRIX-REMODELING-ASSOCIATED PROTEIN 3
Function / homology
Function and homology information
negative regulation of vitamin D receptor signaling pathway / kidney epithelium development / podocyte cell migration / negative regulation of intracellular estrogen receptor signaling pathway / negative regulation of actin filament polymerization / regulation of Rho protein signal transduction / negative regulation of programmed cell death / negative regulation of G1/S transition of mitotic cell cycle / negative regulation of cell population proliferation / apoptotic process ...negative regulation of vitamin D receptor signaling pathway / kidney epithelium development / podocyte cell migration / negative regulation of intracellular estrogen receptor signaling pathway / negative regulation of actin filament polymerization / regulation of Rho protein signal transduction / negative regulation of programmed cell death / negative regulation of G1/S transition of mitotic cell cycle / negative regulation of cell population proliferation / apoptotic process / negative regulation of transcription by RNA polymerase II / mitochondrion / cytoplasm Similarity search - Function
KNmotifandankyrinrepeatdomain-containingprotein2 / Ankyrin repeat domain-containing protein 25 / Matrix-remodeling-associated protein 3 / SRC-1- ...Ankyrin repeat domain-containing protein 25 / Matrix-remodeling-associated protein 3 / SRC-1-interacting protein / SRC1-interacting protein
Mass: 27942.971 Da / Num. of mol.: 1 / Mutation: Yes; A670V Source method: isolated from a genetically manipulated source Details: residues 583-832 / Source: (gene. exp.) Homo sapiens (human) / Gene: KANK2, ANKRD25, KIAA1518, MXRA3, SIP / Plasmid: PET-151-TOPO / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: Q63ZY3
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