Entry Database : PDB / ID : 6th7 Structure visualization Downloads & linksTitle Structure of porcine pancreatic elastase in complex with tutuilamide Components(Tutuilamide) x 2 Chymotrypsin-like elastase family member 1 DetailsKeywords HYDROLASE / elastase / inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
pancreatic elastase / serine-type endopeptidase activity / proteolysis / extracellular space / metal ion binding Similarity search - Function Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan Similarity search - Domain/homologyBiological species Sus scrofa (pig)Synthetic construct (others) Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.2 Å DetailsAuthors Koehnke, J. / Sikandar, A. Funding support Germany, 1items Details Hide detailsOrganization Grant number Country German Research Foundation (DFG) KO4116_3_1 Germany
CitationJournal : Acs Chem.Biol. / Year : 2020Title : Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties.Authors : Keller, L. / Canuto, K.M. / Liu, C. / Suzuki, B.M. / Almaliti, J. / Sikandar, A. / Naman, C.B. / Glukhov, E. / Luo, D. / Duggan, B.M. / Luesch, H. / Koehnke, J. / O'Donoghue, A.J. / Gerwick, W.H. History Deposition Nov 18, 2019 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 4, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Apr 1, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID Revision 2.0 Dec 28, 2022 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Polymer sequence / Source and taxonomy / Structure summary Category : atom_site / database_2 ... atom_site / database_2 / database_PDB_caveat / entity / entity_poly / entity_poly_seq / entity_src_nat / pdbx_entity_nonpoly / pdbx_entity_src_syn / pdbx_nonpoly_scheme / pdbx_poly_seq_scheme / pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / pdbx_validate_chiral / pdbx_validate_rmsd_bond / pdbx_validate_torsion / struct_asym / struct_conn / struct_conn_type / struct_mon_prot_cis / struct_ref / struct_ref_seq / struct_site / struct_site_gen Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _database_PDB_caveat.text / _entity_src_nat.common_name / _pdbx_struct_assembly.oligomeric_count / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_validate_chiral.auth_asym_id / _pdbx_validate_chiral.auth_seq_id / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id / _struct_site.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_seq_id / _struct_site_gen.auth_asym_id / _struct_site_gen.auth_seq_id / _struct_site_gen.label_asym_id / _struct_site_gen.label_seq_id Revision 3.0 Nov 15, 2023 Group : Atomic model / Data collection / Derived calculationsCategory : atom_site / chem_comp_atom ... atom_site / chem_comp_atom / chem_comp_bond / struct_conn Item : _atom_site.auth_atom_id / _atom_site.label_atom_id ... _atom_site.auth_atom_id / _atom_site.label_atom_id / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr2_label_atom_id Revision 3.1 Jan 31, 2024 Group : Refinement description / Category : pdbx_initial_refinement_modelRevision 4.0 May 1, 2024 Group : Polymer sequence / Category : entity_poly / Item : _entity_poly.pdbx_seq_one_letter_code_canRevision 5.0 Jun 26, 2024 Group : Atomic model / Data collection ... Atomic model / Data collection / Derived calculations / Non-polymer description / Polymer sequence / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / chem_comp_atom / chem_comp_bond / entity / entity_poly / entity_poly_seq / pdbx_poly_seq_scheme / pdbx_validate_rmsd_bond / struct_conn / struct_mon_prot_cis / struct_site / struct_site_gen Item : _atom_site.Cartn_x / _atom_site.Cartn_y ... _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_comp_id / _atom_site.group_PDB / _atom_site.label_comp_id / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _entity.formula_weight / _entity_poly.pdbx_seq_one_letter_code / _entity_poly_seq.mon_id / _pdbx_poly_seq_scheme.mon_id / _pdbx_poly_seq_scheme.pdb_mon_id / _pdbx_validate_rmsd_bond.auth_comp_id_1 / _pdbx_validate_rmsd_bond.auth_comp_id_2 / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_label_comp_id / _struct_mon_prot_cis.auth_comp_id / _struct_mon_prot_cis.label_comp_id / _struct_site.pdbx_auth_comp_id / _struct_site_gen.auth_comp_id / _struct_site_gen.label_comp_id Revision 6.0 Jul 10, 2024 Group : Data collection / Non-polymer description / Structure summaryCategory : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / entity Item : _chem_comp.formula / _chem_comp.formula_weight / _entity.formula_weight
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