Entry | Database: PDB / ID: 6taj |
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Title | Crystal structure of Escherichia coli Orotate Phosphoribosyltransferase in complex with Orotic acid 1.60 Angstrom resolution |
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Components | Orotate phosphoribosyltransferase |
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Keywords | TRANSFERASE / Orotate phosphoribosyltransferase (OPRT) / Orotic acid |
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Function / homology | Function and homology information
pyrimidine ribonucleoside biosynthetic process / orotate phosphoribosyltransferase / orotate phosphoribosyltransferase activity / pyrimidine nucleotide biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / magnesium ion binding / protein homodimerization activity / cytoplasm / cytosolSimilarity search - Function Orotate phosphoribosyl transferase domain / Orotate phosphoribosyltransferase / Purine/pyrimidine phosphoribosyl transferases signature. / Phosphoribosyl transferase domain / Phosphoribosyltransferase-like / Phosphoribosyltransferase domainSimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Escherichia coli (E. coli) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.6 Å |
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Authors | Navas-Yuste, S. / Lopez-Estepa, M. / Gomez, S. / Fernandez, F.J. / Vega, M.C. |
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Funding support | Spain, 3items Organization | Grant number | Country |
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Spanish Ministry of Economy and Competitiveness | CTQ2015-66206-C2-2-R | Spain | Spanish Ministry of Science, Innovation, and Universities | RTI2018-1018-102242-B-I00 | Spain | Spanish National Research Council | 2016E064 | Spain |
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Citation | Journal: Acs Catalysis / Year: 2020 Title: Elucidating the Catalytic Reaction Mechanism of Orotate Phosphoribosyltransferase by Means of X-ray Crystallography and Computational Simulations Authors: Roca, M. / Navas-Yuste, S. / Zinovjev, K. / Lopez-Estepa, M. / Gomez, S. / Fernandez, F.J. / Vega, M.C. / Tunon, I. |
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History | Deposition | Oct 29, 2019 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Nov 18, 2020 | Provider: repository / Type: Initial release |
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Revision 2.0 | May 26, 2021 | Group: Atomic model / Category: atom_site / Item: _atom_site.label_alt_id |
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Revision 2.1 | Jun 2, 2021 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation.year / _citation_author.identifier_ORCID |
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Revision 2.2 | Jan 24, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description Category: atom_type / chem_comp_atom ...atom_type / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _atom_type.pdbx_N_electrons / _atom_type.pdbx_scat_Z ..._atom_type.pdbx_N_electrons / _atom_type.pdbx_scat_Z / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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