Entry Database : PDB / ID : 6sak Structure visualization Downloads & linksTitle Structure of the OTULINcat C129A - SNX27 PDZ domain complex. ComponentsSorting nexin-27 Ubiquitin thioesterase otulin DetailsKeywords HYDROLASE / MET1-SPECIFIC DEUBIQUITINASEFunction / homology Function and homology informationFunction Domain/homology Component
establishment of natural killer cell polarity / protein linear deubiquitination / LUBAC complex / regulation of synapse maturation / endocytic recycling / phosphatidylinositol-3-phosphate binding / nucleotide-binding oligomerization domain containing 2 signaling pathway / regulation of tumor necrosis factor-mediated signaling pathway / regulation of canonical Wnt signaling pathway / sprouting angiogenesis ... establishment of natural killer cell polarity / protein linear deubiquitination / LUBAC complex / regulation of synapse maturation / endocytic recycling / phosphatidylinositol-3-phosphate binding / nucleotide-binding oligomerization domain containing 2 signaling pathway / regulation of tumor necrosis factor-mediated signaling pathway / regulation of canonical Wnt signaling pathway / sprouting angiogenesis / endosomal transport / negative regulation of NF-kappaB transcription factor activity / endosome to lysosome transport / regulation of postsynaptic membrane neurotransmitter receptor levels / immunological synapse / cysteine-type peptidase activity / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / phosphatidylinositol binding / Regulation of TNFR1 signaling / intracellular protein transport / Schaffer collateral - CA1 synapse / Wnt signaling pathway / negative regulation of inflammatory response / early endosome membrane / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity / early endosome / endosome / protein ubiquitination / intracellular membrane-bounded organelle / innate immune response / glutamatergic synapse / signal transduction / proteolysis / cytosol / cytoplasm Similarity search - Function Ubiquitin thioesterase otulin / FAM105 / Peptidase family C101 / SNX27, atypical FERM-like domain / SNX27, PX domain / SNX27, RA domain / SNX17/27/31 / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain ... Ubiquitin thioesterase otulin / FAM105 / Peptidase family C101 / SNX27, atypical FERM-like domain / SNX27, PX domain / SNX27, RA domain / SNX17/27/31 / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain / PhoX homologous domain, present in p47phox and p40phox. / PX domain profile. / PX domain / Phox homology / PX domain superfamily / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Ubiquitin-like domain superfamily / Roll / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Elliott, P.R. / Komander, D. Funding support United Kingdom, 2items Details Hide detailsOrganization Grant number Country Medical Research Council (United Kingdom) U105192732 United Kingdom European Research Council 724804 United Kingdom
CitationJournal : Nat Commun / Year : 2019Title : Regulation of the endosomal SNX27-retromer by OTULIN.Authors : Stangl, A. / Elliott, P.R. / Pinto-Fernandez, A. / Bonham, S. / Harrison, L. / Schaub, A. / Kutzner, K. / Keusekotten, K. / Pfluger, P.T. / El Oualid, F. / Kessler, B.M. / Komander, D. / Krappmann, D. History Deposition Jul 17, 2019 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 2, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Jan 24, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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