Entry | Database: PDB / ID: 6s4k |
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Title | The crystal structure of glycogen phosphorylase in complex with 12 |
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Components | Glycogen phosphorylase, muscle form |
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Keywords | TRANSFERASE / phosphorylase / inhibitor / C-beta-D-glucopyranosyl thiazole |
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Function / homology | Function and homology information
glycogen phosphorylase / glycogen phosphorylase activity / linear malto-oligosaccharide phosphorylase activity / SHG alpha-glucan phosphorylase activity / glycogen catabolic process / skeletal muscle myofibril / pyridoxal phosphate binding / nucleotide bindingSimilarity search - Function Glycosyl transferase, family 35 / Glycogen/starch/alpha-glucan phosphorylase / Phosphorylase pyridoxal-phosphate attachment site / Carbohydrate phosphorylase / Phosphorylase pyridoxal-phosphate attachment site. / Glycogen Phosphorylase B; / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) Oryctolagus cuniculus (rabbit) |
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Method | X-RAY DIFFRACTION / FOURIER SYNTHESIS / Resolution: 2.43 Å |
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Authors | Kyriakis, E. / Solovou, T.G.A. / Papaioannou, O.S.E. / Skamnaki, V.T. / Leonidas, D.D. |
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Citation | Journal: Bioorg.Med.Chem. / Year: 2020 Title: The architecture of hydrogen and sulfur sigma-hole interactions explain differences in the inhibitory potency of C-beta-d-glucopyranosyl thiazoles, imidazoles and an N-beta-d glucopyranosyl ...Title: The architecture of hydrogen and sulfur sigma-hole interactions explain differences in the inhibitory potency of C-beta-d-glucopyranosyl thiazoles, imidazoles and an N-beta-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design. Authors: Kyriakis, E. / Karra, A.G. / Papaioannou, O. / Solovou, T. / Skamnaki, V.T. / Liggri, P.G.V. / Zographos, S.E. / Szennyes, E. / Bokor, E. / Kun, S. / Psarra, A.G. / Somsak, L. / Leonidas, D.D. |
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History | Deposition | Jun 28, 2019 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Feb 19, 2020 | Provider: repository / Type: Initial release |
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