登録情報 | データベース: PDB / ID: 6s27 |
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タイトル | Crystal structure of human wild type STING in complex with 2'3'-cyclic-GMP-2'F-2'dAMP |
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要素 | Stimulator of interferon protein |
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キーワード | PROTEIN BINDING / Activator / Membrane protein / Immune system / Receptor |
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機能・相同性 | 機能・相同性情報
STING complex / STAT6-mediated induction of chemokines / serine/threonine protein kinase complex / protein localization to endoplasmic reticulum / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway ...STING complex / STAT6-mediated induction of chemokines / serine/threonine protein kinase complex / protein localization to endoplasmic reticulum / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway / cGAS/STING signaling pathway / reticulophagy / pattern recognition receptor signaling pathway / cytoplasmic pattern recognition receptor signaling pathway / cellular response to exogenous dsRNA / autophagosome membrane / antiviral innate immune response / positive regulation of macroautophagy / cellular response to organic cyclic compound / autophagosome assembly / autophagosome / positive regulation of type I interferon production / cellular response to interferon-beta / signaling adaptor activity / positive regulation of defense response to virus by host / Regulation of innate immune responses to cytosolic DNA / activation of innate immune response / positive regulation of interferon-beta production / endoplasmic reticulum-Golgi intermediate compartment membrane / secretory granule membrane / cytoplasmic vesicle membrane / positive regulation of DNA-binding transcription factor activity / peroxisome / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of protein binding / protein complex oligomerization / regulation of inflammatory response / cytoplasmic vesicle / defense response to virus / RNA polymerase II-specific DNA-binding transcription factor binding / mitochondrial outer membrane / endosome / Golgi membrane / innate immune response / ubiquitin protein ligase binding / Neutrophil degranulation / endoplasmic reticulum membrane / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / perinuclear region of cytoplasm / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / plasma membrane / cytosol類似検索 - 分子機能 Stimulator of interferon genes protein / : / Stimulator of interferon genes protein / Stimulator of interferon genes protein, C-terminal domain superfamily / Transmembrane protein 173 / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 2'3'-cyclic-GMP-2'F-2'dAMP / Stimulator of interferon genes protein / Stimulator of interferon genes protein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.802 Å |
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データ登録者 | Smola, M. / Boura, E. |
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資金援助 | チェコ, 1件 組織 | 認可番号 | 国 |
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European Regional Development Fund | CZ.02.1.01/0.0/0.0/16_019/0000729 | チェコ |
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引用 | ジャーナル: J.Med.Chem. / 年: 2019 タイトル: Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations. 著者: Novotna, B. / Vanekova, L. / Zavrel, M. / Budesinsky, M. / Dejmek, M. / Smola, M. / Gutten, O. / Tehrani, Z.A. / Pimkova Polidarova, M. / Brazdova, A. / Liboska, R. / Stepanek, I. / Vavrina, ...著者: Novotna, B. / Vanekova, L. / Zavrel, M. / Budesinsky, M. / Dejmek, M. / Smola, M. / Gutten, O. / Tehrani, Z.A. / Pimkova Polidarova, M. / Brazdova, A. / Liboska, R. / Stepanek, I. / Vavrina, Z. / Jandusik, T. / Nencka, R. / Rulisek, L. / Boura, E. / Brynda, J. / Pav, O. / Birkus, G. |
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履歴 | 登録 | 2019年6月20日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年11月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年12月4日 | Group: Database references / カテゴリ: citation / Item: _citation.title |
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改定 1.2 | 2019年12月25日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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