登録情報 データベース : PDB / ID : 6rhv 構造の表示 ダウンロードとリンクタイトル Crystal structure of mouse CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH (LukH K319A mutant) 要素(Beta-channel forming ...) x 2 Integrin alpha-M 詳細キーワード TOXIN / LEUKOCIDIN / PORE-FORMING TOXIN / OCTAMER / receptor / complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of mast cell differentiation / positive regulation of hippocampal neuron apoptotic process / : / : / leukocyte adhesion to vascular endothelial cell / Toll Like Receptor 4 (TLR4) Cascade / : / cellular extravasation / positive regulation of prostaglandin-E synthase activity / positive regulation of neutrophil degranulation ... positive regulation of mast cell differentiation / positive regulation of hippocampal neuron apoptotic process / : / : / leukocyte adhesion to vascular endothelial cell / Toll Like Receptor 4 (TLR4) Cascade / : / cellular extravasation / positive regulation of prostaglandin-E synthase activity / positive regulation of neutrophil degranulation / integrin alphaM-beta2 complex / positive regulation of microglial cell mediated cytotoxicity / opsonin binding / neutrophil apoptotic process / Integrin cell surface interactions / Cell surface interactions at the vascular wall / complement component C3b binding / cytolysis in another organism / vertebrate eye-specific patterning / complement-mediated synapse pruning / negative regulation of dopamine metabolic process / leukocyte migration involved in inflammatory response / activated T cell proliferation / microglia development / heparan sulfate proteoglycan binding / cargo receptor activity / leukocyte cell-cell adhesion / phagocytosis, engulfment / amyloid-beta clearance / plasma membrane raft / positive regulation of protein targeting to membrane / phagocytosis / forebrain development / heat shock protein binding / Neutrophil degranulation / neutrophil chemotaxis / receptor-mediated endocytosis / positive regulation of superoxide anion generation / integrin-mediated signaling pathway / apoptotic signaling pathway / microglial cell activation / cell-cell adhesion / heparin binding / membrane => GO:0016020 / cell adhesion / external side of plasma membrane / protein-containing complex binding / cell surface / extracellular space / extracellular region / nucleus / metal ion binding / plasma membrane 類似検索 - 分子機能 Leukocidin/porin MspA / Leukocidin-like / Bi-component toxin, staphylococci / Leukocidin/Hemolysin toxin / Leukocidin/Hemolysin toxin family / Leukocidin/porin MspA superfamily / Integrin alpha cytoplasmic region / von Willebrand factor, type A domain / Integrin alpha-2 / Integrin alpha Ig-like domain 1 ... Leukocidin/porin MspA / Leukocidin-like / Bi-component toxin, staphylococci / Leukocidin/Hemolysin toxin / Leukocidin/Hemolysin toxin family / Leukocidin/porin MspA superfamily / Integrin alpha cytoplasmic region / von Willebrand factor, type A domain / Integrin alpha-2 / Integrin alpha Ig-like domain 1 / Integrin alpha chain / Integrin alpha beta-propellor / Integrin alpha chain, C-terminal cytoplasmic region, conserved site / Integrins alpha chain signature. / FG-GAP repeat profile. / Integrin alpha (beta-propellor repeats). / FG-GAP repeat / FG-GAP repeat / Integrin alpha, N-terminal / Integrin domain superfamily / von Willebrand factor type A domain / von Willebrand factor (vWF) type A domain / VWFA domain profile. / von Willebrand factor, type A / von Willebrand factor A-like domain superfamily / Distorted Sandwich / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性 Beta-channel forming cytolysin / Beta-channel forming cytolysin / Integrin alpha-M / Uncharacterized leukocidin-like protein 2 / Uncharacterized leukocidin-like protein 1 類似検索 - 構成要素生物種 Staphylococcus aureus (黄色ブドウ球菌)Mus musculus (ハツカネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.29 Å 詳細データ登録者 Trstenjak, N. / Milic, D. / Djinovic-Carugo, K. / Badarau, A. 資金援助 オーストリア, 1件 詳細 詳細を隠す組織 認可番号 国 Christian Doppler Forschungsgesellschaft CD-Laboratory for High-Content Structural Biology and Biotechnology オーストリア
引用ジャーナル : Proc.Natl.Acad.Sci.USA / 年 : 2020タイトル : Molecular mechanism of leukocidin GH-integrin CD11b/CD18 recognition and species specificity.著者 : Trstenjak, N. / Milic, D. / Graewert, M.A. / Rouha, H. / Svergun, D. / Djinovic-Carugo, K. / Nagy, E. / Badarau, A. 履歴 登録 2019年4月23日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2019年12月18日 Provider : repository / タイプ : Initial release改定 1.1 2020年1月1日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed ... _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID 改定 1.2 2020年1月15日 Group : Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year 改定 1.3 2024年1月24日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id
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