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Structure paper

TitleMolecular mechanism of leukocidin GH-integrin CD11b/CD18 recognition and species specificity.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 117, Page 317-327, Year 2020
Publish dateApr 23, 2019 (structure data deposition date)
AuthorsTrstenjak, N. / Milic, D. / Graewert, M.A. / Rouha, H. / Svergun, D. / Djinovic-Carugo, K. / Nagy, E. / Badarau, A.
External linksProc. Natl. Acad. Sci. USA / PubMed:31852826
MethodsX-ray diffraction
Resolution2.29 - 2.75 Å
Structure data

PDB-6rhv:
Crystal structure of mouse CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH (LukH K319A mutant)
Method: X-RAY DIFFRACTION / Resolution: 2.29 Å

PDB-6rhw:
Crystal structure of human CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • staphylococcus aureus (bacteria)
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsTOXIN / LEUKOCIDIN / PORE-FORMING TOXIN / OCTAMER / receptor / complex

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