登録情報 | データベース: PDB / ID: 6qlz |
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タイトル | IDOL F3ab subdomain |
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要素 | E3 ubiquitin-protein ligase MYLIP |
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キーワード | LIGASE / E3 LIGASE CHOLESTEROL METABOLISM LDLR degradation |
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機能・相同性 | 機能・相同性情報
regulation of low-density lipoprotein particle receptor catabolic process / negative regulation of low-density lipoprotein particle clearance / NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake / cytoskeletal protein binding / VLDLR internalisation and degradation / cholesterol homeostasis / protein destabilization / RING-type E3 ubiquitin transferase / positive regulation of protein catabolic process / ubiquitin-protein transferase activity ...regulation of low-density lipoprotein particle receptor catabolic process / negative regulation of low-density lipoprotein particle clearance / NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake / cytoskeletal protein binding / VLDLR internalisation and degradation / cholesterol homeostasis / protein destabilization / RING-type E3 ubiquitin transferase / positive regulation of protein catabolic process / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / negative regulation of neuron projection development / nervous system development / ubiquitin-dependent protein catabolic process / cytoskeleton / protein ubiquitination / metal ion binding / plasma membrane / cytosol類似検索 - 分子機能 MYLIP, FERM domain C-lobe / Ezrin/radixin/moesin-like / FERM, C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM, N-terminal / FERM N-terminal domain / FERM central domain / Zinc finger, C3HC4 type (RING finger) / FERM/acyl-CoA-binding protein superfamily ...MYLIP, FERM domain C-lobe / Ezrin/radixin/moesin-like / FERM, C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM C-terminal PH-like domain / FERM, N-terminal / FERM N-terminal domain / FERM central domain / Zinc finger, C3HC4 type (RING finger) / FERM/acyl-CoA-binding protein superfamily / FERM central domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Zinc finger RING-type profile. / Zinc finger, RING-type / PH-like domain superfamily / Zinc finger, RING/FYVE/PHD-type / Ubiquitin-like domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.343 Å |
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データ登録者 | Martinelli, L. / Johansson, P. / Wan, P.T. / Gunnarsson, J. / Guo, H. / Boyd, H. |
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資金援助 | オランダ, 1件 組織 | 認可番号 | 国 |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2020 タイトル: Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site. 著者: Martinelli, L. / Adamopoulos, A. / Johansson, P. / Wan, P.T. / Gunnarsson, J. / Guo, H. / Boyd, H. / Zelcer, N. / Sixma, T.K. |
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履歴 | 登録 | 2019年2月1日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2020年2月19日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年8月12日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID |
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改定 1.2 | 2020年10月7日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID |
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改定 1.3 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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