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- PDB-6p67: Crystal Structure of a Complex of human IL-7Ralpha with an anti-I... -
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Open data
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Basic information
Entry | Database: PDB / ID: 6p67 | |||||||||
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Title | Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab | |||||||||
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![]() | IMMUNE SYSTEM / Interleukin-7 receptor extracellular dohmain / antibody 2B8 Fab fragment / protein polymer | |||||||||
Function / homology | ![]() interleukin-7 receptor activity / positive regulation of receptor signaling pathway via STAT / negative regulation of T cell mediated cytotoxicity / regulation of DNA recombination / positive regulation of T cell differentiation in thymus / negative regulation of T cell apoptotic process / cytokine receptor activity / regulation of cell size / B cell proliferation / T cell homeostasis ...interleukin-7 receptor activity / positive regulation of receptor signaling pathway via STAT / negative regulation of T cell mediated cytotoxicity / regulation of DNA recombination / positive regulation of T cell differentiation in thymus / negative regulation of T cell apoptotic process / cytokine receptor activity / regulation of cell size / B cell proliferation / T cell homeostasis / B cell homeostasis / hemopoiesis / lymph node development / Interleukin-7 signaling / antigen binding / positive regulation of receptor signaling pathway via JAK-STAT / clathrin-coated endocytic vesicle membrane / cell morphogenesis / T cell mediated cytotoxicity / cytokine-mediated signaling pathway / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / gene expression / T cell differentiation in thymus / cell surface receptor signaling pathway / defense response to Gram-positive bacterium / immune response / external side of plasma membrane / positive regulation of cell population proliferation / positive regulation of gene expression / signal transduction / extracellular region / nucleoplasm / plasma membrane / cytosol Similarity search - Function | |||||||||
Biological species | ![]() ![]() ![]() | |||||||||
Method | ![]() ![]() ![]() | |||||||||
![]() | Walsh, S.T.R. / Kashi, L. / Kohnhorst, C.L. | |||||||||
Funding support | ![]()
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![]() | ![]() Title: New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models. Authors: Hixon, J.A. / Andrews, C. / Kashi, L. / Kohnhorst, C.L. / Senkevitch, E. / Czarra, K. / Barata, J.T. / Li, W. / Schneider, J.P. / Walsh, S.T.R. / Durum, S.K. | |||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 599.7 KB | Display | ![]() |
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PDB format | ![]() | 397.6 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 1.3 MB | Display | ![]() |
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Full document | ![]() | 1.4 MB | Display | |
Data in XML | ![]() | 83.2 KB | Display | |
Data in CIF | ![]() | 111.6 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 6p4ySC ![]() 6p50C ![]() 3di3S S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Assembly
Deposited unit | ![]()
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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