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TitleNew anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Journal, issue, pagesLeukemia, Vol. 34, Page 35-49, Year 2020
Publish dateMay 29, 2019 (structure data deposition date)
AuthorsHixon, J.A. / Andrews, C. / Kashi, L. / Kohnhorst, C.L. / Senkevitch, E. / Czarra, K. / Barata, J.T. / Li, W. / Schneider, J.P. / Walsh, S.T.R. / Durum, S.K.
External linksLeukemia / PubMed:31439943
MethodsX-ray diffraction
Resolution1.799 - 2.9 Å
Structure data

PDB-6p4y:
Crystal Structure of anti-IL-7Ralpha 4A10 Fab
Method: X-RAY DIFFRACTION / Resolution: 1.799 Å

PDB-6p50:
Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha Fab 4A10
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-6p67:
Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-FUC:
alpha-L-fucopyranose

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody 4A10 Fab fragment / protein polymer / Interleukin-7 receptor extracellular dohmain / antibody 2B8 Fab fragment

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