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- PDB-6otc: Synthetic Fab bound to Marburg virus VP35 interferon inhibitory domain -

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Basic information

Entry
Database: PDB / ID: 6otc
TitleSynthetic Fab bound to Marburg virus VP35 interferon inhibitory domain
Components
  • Polymerase cofactor VP35
  • sFab H3 heavy chain
  • sFab H3 light chain
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / Marburg virus / Fab / VIRAL PROTEIN-IMMUNE SYSTEM complex
Function / homology
Function and homology information


virion component / host cell cytoplasm
Similarity search - Function
Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain / Filoviridae VP35, C-terminal inhibitory domain, helical subdomain / Filoviruses VP35 interferon inhibitory domain, beta-sheet subdomain / Filoviridae VP35 protein / Filoviruses VP35 interferon inhibitory domain / Filoviruses VP35 interferon inhibitory domain, helical subdomain / Filoviridae VP35 / Filoviruses VP35 interferon inhibitory domain profile. / Seminal Fluid Protein PDC-109 (Domain B) / Helicase, Ruva Protein; domain 3 ...Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain / Filoviridae VP35, C-terminal inhibitory domain, helical subdomain / Filoviruses VP35 interferon inhibitory domain, beta-sheet subdomain / Filoviridae VP35 protein / Filoviruses VP35 interferon inhibitory domain / Filoviruses VP35 interferon inhibitory domain, helical subdomain / Filoviridae VP35 / Filoviruses VP35 interferon inhibitory domain profile. / Seminal Fluid Protein PDC-109 (Domain B) / Helicase, Ruva Protein; domain 3 / Ribbon / Immunoglobulins / Immunoglobulin-like / Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha
Similarity search - Domain/homology
Polymerase cofactor VP35
Similarity search - Component
Biological speciesLake Victoria marburgvirus
synthetic construct (others)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.7 Å
AuthorsAmatya, P. / Chen, G. / Borek, D. / Sidhu, S.S. / Leung, D.W.
Funding support United States, 3items
OrganizationGrant numberCountry
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)P01AI120943 United States
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)R01AI140758 United States
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)P41GM103422 United States
CitationJournal: Acs Infect Dis. / Year: 2019
Title: Inhibition of Marburg Virus RNA Synthesis by a Synthetic Anti-VP35 Antibody.
Authors: Amatya, P. / Wagner, N. / Chen, G. / Luthra, P. / Shi, L. / Borek, D. / Pavlenco, A. / Rohrs, H. / Basler, C.F. / Sidhu, S.S. / Gross, M.L. / Leung, D.W.
History
DepositionMay 2, 2019Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jun 5, 2019Provider: repository / Type: Initial release
Revision 1.1Jul 10, 2019Group: Data collection / Database references / Category: citation / citation_author / Item: _citation.title / _citation_author.name
Revision 1.2Aug 21, 2019Group: Data collection / Database references / Category: citation
Item: _citation.journal_volume / _citation.page_first / _citation.page_last
Revision 1.3Dec 18, 2019Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization
Revision 1.4Oct 11, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 1.5Oct 9, 2024Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Polymerase cofactor VP35
H: sFab H3 heavy chain
L: sFab H3 light chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)65,3615
Polymers65,2333
Non-polymers1282
Water11,223623
1


  • Idetical with deposited unit
  • defined by author
  • Evidence: isothermal titration calorimetry
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area4710 Å2
ΔGint-40 kcal/mol
Surface area25490 Å2
2
H: sFab H3 heavy chain
L: sFab H3 light chain
hetero molecules

A: Polymerase cofactor VP35


Theoretical massNumber of molelcules
Total (without water)65,3615
Polymers65,2333
Non-polymers1282
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
crystal symmetry operation4_555x+1/2,-y+1/2,-z1
Buried area5930 Å2
ΔGint-52 kcal/mol
Surface area24260 Å2
MethodPISA
Unit cell
Length a, b, c (Å)57.827, 97.422, 110.325
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number18
Space group name H-MP21212
Components on special symmetry positions
IDModelComponents
11L-456-

HOH

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Components

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Protein , 1 types, 1 molecules A

#1: Protein Polymerase cofactor VP35 / Marburg VP35 / mVP35


Mass: 14132.365 Da / Num. of mol.: 1
Fragment: interferon inhibitory domain (UNP residues 204-329)
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Lake Victoria marburgvirus (strain Popp-67)
Strain: Popp-67 / Gene: VP35 / Production host: Escherichia coli (E. coli) / References: UniProt: Q03039

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Antibody , 2 types, 2 molecules HL

#2: Antibody sFab H3 heavy chain


Mass: 25834.715 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) synthetic construct (others) / Production host: Escherichia coli (E. coli)
#3: Antibody sFab H3 light chain


Mass: 25265.889 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) synthetic construct (others) / Production host: Escherichia coli (E. coli)

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Non-polymers , 3 types, 625 molecules

#4: Chemical ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL


Mass: 92.094 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C3H8O3
#5: Chemical ChemComp-CL / CHLORIDE ION


Mass: 35.453 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: Cl
#6: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 623 / Source method: isolated from a natural source / Formula: H2O

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Details

Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.6 Å3/Da / Density % sol: 52.6 %
Crystal growTemperature: 293.15 K / Method: vapor diffusion, hanging drop / pH: 6.5 / Details: 10 mM Bis-Tris, pH 6.5, 20% PEG5000 MME

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 19-ID / Wavelength: 0.97918 Å
DetectorType: ADSC QUANTUM 315r / Detector: CCD / Date: Jun 5, 2017
RadiationMonochromator: double crystal Si(111) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.97918 Å / Relative weight: 1
ReflectionResolution: 1.7→36.96 Å / Num. obs: 68713 / % possible obs: 99.4 % / Redundancy: 6.9 % / Net I/σ(I): 15.8
Reflection shellResolution: 1.7→1.73 Å / Num. unique obs: 3348

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Processing

Software
NameVersionClassification
REFMAC5.8.0238refinement
PDB_EXTRACT3.25data extraction
HKL-3000data reduction
HKL-3000data scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: PDB entries 4GHL & 1TZI

4ghl

1tzi


Resolution: 1.7→36.96 Å / Cor.coef. Fo:Fc: 0.942 / Cor.coef. Fo:Fc free: 0.921 / SU B: 5.071 / SU ML: 0.088 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R: 0.121 / ESU R Free: 0.118
Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : WITH TLS ADDED
RfactorNum. reflection% reflectionSelection details
Rfree0.233 3147 4.8 %RANDOM
Rwork0.1958 ---
obs0.1976 61776 93.83 %-
Solvent computationIon probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å
Displacement parametersBiso max: 81.48 Å2 / Biso mean: 20.163 Å2 / Biso min: 8.15 Å2
Baniso -1Baniso -2Baniso -3
1--0.29 Å2-0 Å2-0 Å2
2--0.07 Å2-0 Å2
3---0.22 Å2
Refinement stepCycle: final / Resolution: 1.7→36.96 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms4219 0 7 625 4851
Biso mean--47.58 27.85 -
Num. residues----553
Refine LS restraints
Refine-IDTypeDev idealDev ideal targetNumber
X-RAY DIFFRACTIONr_bond_refined_d0.0060.0134573
X-RAY DIFFRACTIONr_bond_other_d0.0070.0174113
X-RAY DIFFRACTIONr_angle_refined_deg1.3071.6416269
X-RAY DIFFRACTIONr_angle_other_deg1.2981.5689600
X-RAY DIFFRACTIONr_dihedral_angle_1_deg7.1535604
X-RAY DIFFRACTIONr_dihedral_angle_2_deg31.38522.183197
X-RAY DIFFRACTIONr_dihedral_angle_3_deg12.85915721
X-RAY DIFFRACTIONr_dihedral_angle_4_deg12.7591521
X-RAY DIFFRACTIONr_chiral_restr0.0530.2603
X-RAY DIFFRACTIONr_gen_planes_refined0.0060.025253
X-RAY DIFFRACTIONr_gen_planes_other0.0010.02970
LS refinement shellResolution: 1.701→1.745 Å / Rfactor Rfree error: 0 / Total num. of bins used: 20
RfactorNum. reflection% reflection
Rfree0.304 152 -
Rwork0.251 3022 -
all-3174 -
obs--63.15 %
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
17.75790.85280.34981.7357-0.85082.3342-0.02420.1177-0.3604-0.10970.06620.02940.14440.0317-0.0420.1424-0.0125-0.0050.11410.00180.1049-2.416319.14490.0535
24.214-0.86780.09572.62190.54378.95960.0425-0.025-0.2039-0.02590.20390.01430.2055-0.1489-0.24640.1389-0.0186-0.00110.12030.0350.08711.955523.8832.5377
31.2551-2.71750.22775.9102-0.51152.21540.0749-0.05410.0185-0.22270.0875-0.02420.01070.0605-0.16230.1597-0.0131-0.00580.12330.00810.11165.603131.17934.7632
40.4870.51381.57897.72651.57675.2885-0.05290.00570.0494-0.13180.05250.2443-0.2447-0.0770.00040.14660.0370.03020.13160.06630.17530.720433.429-1.1465
53.42941.45911.19037.13951.44990.5948-0.04880.04480.02480.01570.02020.1107-0.0468-0.06730.02860.12280.013-0.00210.18440.00660.0892-4.459626.4037-6.601
69.05911.7829-0.73426.9242-3.72174.6464-0.00870.33930.3017-0.01990.01460.1780.1663-0.3211-0.00590.1035-0.0365-0.03260.1365-0.03330.0785-5.118719.1315-9.8927
74.7619-0.04122.70440.55720.47382.6020.0377-0.1596-0.0838-0.1078-0.04610.06320.2393-0.09550.00840.1964-0.00850.0090.13080.00090.07636.058519.6429-6.4759
81.2842-1.76740.60566.45253.20886.1138-0.0470.15640.1132-0.0359-0.07730.0768-0.02450.05420.12430.11860.01440.01920.16310.02430.073215.246724.7813-6.8419
94.0135-0.64994.0580.889-0.40796.76120.01050.05680.30460.0501-0.04340.0058-0.0005-0.03490.03290.1261-0.00780.01940.13260.02690.09379.188130.9265-4.7201
1010.99611.9933-2.35232.899-0.93093.34810.10180.6886-0.09920.038-0.0799-0.13780.01980.0185-0.02190.14970.01470.00540.15450.04830.0427.435729.8702-12.2566
117.7421.08190.36957.0232-2.72788.95370.11650.2513-0.296-0.09620.01-0.14530.2654-0.0502-0.12650.12590.0169-0.00210.198-0.01210.01631.88724.849-14.5312
1211.8043-6.4329-11.721812.47619.553113.35520.14180.67880.4152-0.3813-0.00420.70190.0305-0.199-0.13760.19990.1198-0.0670.27760.04090.1196-6.20530.7491-14.4299
136.44952.54950.53381.4861.95726.43750.0383-0.94760.2679-0.0569-0.29740.1783-0.22140.20260.25910.1218-0.0358-0.03590.1898-0.03410.13-14.705537.6422-0.8624
146.1888-0.3891-7.00162.65843.344811.14750.2105-0.53280.2419-0.158-0.21390.1903-0.43320.28370.00340.09670.0761-0.05920.1647-0.13270.1506-10.682344.9511.6919
1510.1426-0.70397.31651.8321-5.800720.9927-0.4957-0.41690.51650.1840.0861-0.0539-0.8142-0.48030.40960.12010.0408-0.03530.0822-0.00680.1799-1.495942.56854.2058
160.1036-0.7941-0.45518.29262.394427.2196-0.08770.00060.0910.1166-0.0572-0.2246-0.59830.59750.14490.2796-0.0075-0.22030.04560.05910.2924-1.363445.8645-3.778
173.2926-2.33063.87551.6523-2.73494.5907-0.00370.50070.2423-0.001-0.3426-0.1527-0.00490.6260.34630.1269-0.0251-0.03150.13650.12560.1572-7.930941.9321-16.0449
183.06831.87853.74168.15472.03446.26290.31350.26580.6803-0.2925-0.52310.3260.34510.37240.20960.0710.05550.09310.25560.10250.3909-1.620635.5635-14.9373
1912.609-7.705-2.30455.27720.72222.3282-0.27190.02290.47680.1693-0.0128-0.12520.086-0.05850.28470.0716-0.0281-0.00860.0883-0.02610.3743-12.17840.3867-4.374
2010.9842-5.17340.37543.46951.86984.3182-0.19970.22350.3132-0.1582-0.05540.0213-0.3620.21030.25520.14250.0393-0.08380.07130.04940.2154-6.442842.5714-7.5832
214.44682.3112-5.71345.4075-3.15587.4707-0.04050.12910.16860.10650.15830.2418-0.0034-0.2101-0.11780.1160.0311-0.00510.1355-0.00290.120420.219235.7768-16.283
221.53910.5472-3.92310.195-1.398910.05740.12180.00880.02420.05170.00340.0108-0.3823-0.0416-0.12520.18070.02720.01780.11290.0220.109731.319941.1302-31.8455
232.03660.6481-3.94911.5109-2.05939.34240.09460.0363-0.04020.1106-0.2271-0.046-0.44970.07890.13260.1307-0.0062-0.02440.1040.03190.103638.312541.3693-31.0756
240.028-0.0948-0.02740.6947-0.65291.8794-0.024-0.00360.01840.05190.0049-0.0208-0.0364-0.05650.01910.14130.0048-0.0020.13230.00650.10829.583432.633-17.0684
257.183-3.00423.32188.68542.45763.60320.03920.3976-0.2011-0.3725-0.05820.1011-0.0360.26710.0190.33460.0190.12980.0850.02970.169931.266624.1706-33.8749
260.08450.1308-0.60650.956-0.3294.88750.0005-0.025-0.01180.0257-0.1046-0.0366-0.04350.15480.10420.12690.0079-0.00880.13130.020.099538.372529.4787-15.1631
272.3652-1.8857-2.63783.61322.39815.29370.0275-0.02530.0210.1158-0.2188-0.21450.07680.27830.19130.10740.0157-0.00810.14120.06520.098542.680432.2528-24.6128
283.3826-1.1386-4.80540.53351.44937.5721-0.04030.01330.10640.0708-0.0404-0.0289-0.23080.04110.08070.1910.0029-0.04920.10.01310.134334.058440.6809-17.1584
296.39242.34782.0224.87424.10219.15970.01890.3597-0.26980.0833-0.1348-0.41720.19610.44750.11590.09040.02170.01210.14510.07470.09241.873834.1241-34.3236
300.12470.2661-0.32210.8626-1.37913.4154-0.01830.00460.0506-0.03670.11730.03840.0924-0.2002-0.0990.13850.00240.0040.13170.02360.101827.634128.7069-21.3334
310.3346-0.28670.18840.6855-0.95942.98310.05370.0757-0.0286-0.05150.03310.05860.0888-0.1474-0.08680.1239-0.0110.0010.14430.03470.094525.622127.0014-19.2062
321.53960.06940.76880.6052-0.40020.7972-0.02650.00790.0373-0.0387-0.02620.04080.02430.05420.05260.14960.00140.01660.0925-0.00370.117729.670541.8981-44.7097
338.94892.35971.83811.98790.58540.3866-0.16030.5805-0.0693-0.12860.1840.032-0.04330.1236-0.02370.1121-0.0257-0.00450.157-0.00040.125311.067737.8003-58.5215
3410.38628.5036.36567.25985.03444.00910.0725-0.33730.24780.1109-0.14340.30830.0196-0.27790.07080.0814-0.0186-0.02160.1470.01080.18083.494232.2309-55.7469
352.27410.78820.61460.57450.48490.44070.0379-0.08080.0350.0682-0.07030.06340.0322-0.02120.03240.1203-0.0050.01880.0865-0.01230.149214.842337.1825-45.9204
367.84910.3837-1.29870.83460.10850.6711-0.070.0506-0.1536-0.01370.05870.01180.00650.01920.01130.11250.00090.0010.0961-0.01910.127925.481734.4449-49.5456
3711.7395-2.03036.6620.4034-1.08673.8659-0.0193-0.06760.3775-0.0177-0.0834-0.1404-0.0134-0.14660.10270.1309-0.00470.01090.21390.06420.19462.297732.686-52.4508
385.84520.1112.185914.420116.184418.8931-0.1762-0.06730.74210.3633-0.15440.06380.3436-0.21940.33060.0165-0.0078-0.03680.20740.06410.2411-3.863639.1808-56.1442
398.213.41215.24551.67921.49755.1421-0.1131-0.10040.2175-0.02320.03020.1119-0.1162-0.23510.08280.08680.018-0.00180.0879-0.00070.1966.845743.1775-49.6043
404.26822.28552.511.78681.82972.0943-0.12920.0360.30660.0145-0.02570.285-0.13780.00340.15490.1538-0.00650.0390.0696-0.00630.210514.375545.9098-48.1556
417.53935.01562.45674.89933.16433.0370.24150.061-0.25610.035-0.0914-0.3940.16190.0902-0.150.17590.04860.00970.11090.02060.140636.447111.5226-23.5557
423.0332-0.5050.95741.2181-0.74182.82370.12570.2143-0.1123-0.33270.0370.03880.77340.0989-0.16280.3389-0.0565-0.0760.0620.01090.029517.00899.583-33.793
4310.5929-0.58584.04730.52680.0261.68790.10890.0754-0.15160.001-0.0243-0.00820.09540.0194-0.08460.1966-0.0091-0.0190.09690.00980.091722.87326.6478-25.8681
441.60420.07132.29460.00830.09583.29490.1666-0.0352-0.1346-0.01520.01980.00140.2871-0.0619-0.18630.2575-0.0126-0.01880.10970.02030.092228.784612.3834-17.8752
450.6213-0.3770.76011.4464-1.72844.5676-0.0377-0.0291-0.0557-0.08940.04460.0653-0.0438-0.1609-0.00690.1446-0.0339-0.02040.12620.02190.089619.557921.3508-23.5271
461.9091-1.05070.11661.26970.15782.27020.137-0.2053-0.1265-0.08940.04480.11030.3292-0.4313-0.18180.1586-0.063-0.02460.11430.040.06717.05113.2467-18.0082
476.1594-1.73332.75770.7722-1.3432.3915-0.1839-0.3002-0.1716-0.19530.2280.02220.4332-0.3914-0.0440.2877-0.1201-0.04710.12310.00850.09316.18619.7512-24.8342
481.30890.09961.16860.2544-0.25091.52060.0085-0.0453-0.0352-0.12180.0231-0.0080.2111-0.0794-0.03160.1851-0.0277-0.02340.12380.00540.084122.41217.9544-24.6597
494.37061.47323.7391.46131.7896.3197-0.01620.0596-0.1256-0.08530.0675-0.0790.03790.2552-0.05130.11970.0214-0.00080.11320.00570.100337.191420.4496-16.1606
505.96890.9133.07540.73180.19841.7161-0.00210.0935-0.0309-0.17560.0342-0.00970.06350.0398-0.03210.1637-0.0068-0.01030.1161-0.00570.094722.387514.9992-33.7983
510.75150.07932.0161.5328-1.92898.43260.1481-0.0317-0.03950.0918-0.0237-0.00070.3041-0.0942-0.12440.1549-0.0334-0.03020.1157-0.0220.11167.684213.4494-45.6534
522.95744.4911-0.18477.0489-0.65420.6351-0.22870.12060.1606-0.33720.20930.2407-0.0178-0.07470.01940.1526-0.0109-0.02240.11380.00760.113213.907234.3684-61.8047
531.75593.3781-1.66876.5405-3.36052.8631-0.1040.03580.0007-0.22310.02260.00760.0892-0.00770.08130.1103-0.0002-0.03110.1022-0.01150.113615.422229.7481-56.431
543.38294.0976-1.54615.0221-2.47611.710.0966-0.0883-0.17030.1014-0.0685-0.23310.26360.5617-0.02810.05850.0312-0.04820.1971-0.06190.140417.292715.8552-52.0114
553.0863-0.54541.06493.66511.47122.83680.08120.0757-0.2081-0.16620.2132-0.18940.02120.1531-0.29440.0692-0.04330.0060.1806-0.07280.09622.160822.1151-66.5865
565.36152.8037-4.61391.8117-1.81235.12890.2650.04370.21370.2532-0.00970.0151-0.0354-0.0944-0.25530.1194-0.0101-0.02310.1024-0.01580.123414.610423.892-45.5643
571.62571.824-2.42082.4102-2.68084.1064-0.0349-0.0337-0.1534-0.0553-0.0916-0.1550.02960.13960.12650.1253-0.0378-0.00280.1233-0.02440.101619.778529.1122-58.2648
582.35723.9143-2.28447.5481-5.9936.9769-0.14610.16250.0413-0.29550.14710.0760.08090.2081-0.0010.2426-0.0905-0.03710.1892-0.02160.071319.311128.4125-70.8274
592.10772.21750.12353.1889-0.61640.6892-0.09220.133-0.2135-0.03790.1719-0.2087-0.0032-0.0176-0.07970.1264-0.0119-0.0410.1041-0.05210.140710.676515.1251-59.3487
606.452-0.8787-7.1270.46240.66948.13780.39510.2773-0.0201-0.2602-0.19990.2413-0.2725-0.166-0.19520.28490.0048-0.15590.2051-0.07970.176314.125531.7034-70.6735
Refinement TLS group
IDRefine-IDRefine TLS-IDAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1A208 - 213
2X-RAY DIFFRACTION2A214 - 218
3X-RAY DIFFRACTION3A219 - 225
4X-RAY DIFFRACTION4A226 - 233
5X-RAY DIFFRACTION5A234 - 238
6X-RAY DIFFRACTION6A239 - 244
7X-RAY DIFFRACTION7A245 - 253
8X-RAY DIFFRACTION8A254 - 260
9X-RAY DIFFRACTION9A261 - 267
10X-RAY DIFFRACTION10A268 - 271
11X-RAY DIFFRACTION11A272 - 276
12X-RAY DIFFRACTION12A277 - 282
13X-RAY DIFFRACTION13A283 - 287
14X-RAY DIFFRACTION14A288 - 292
15X-RAY DIFFRACTION15A293 - 296
16X-RAY DIFFRACTION16A297 - 301
17X-RAY DIFFRACTION17A302 - 307
18X-RAY DIFFRACTION18A308 - 313
19X-RAY DIFFRACTION19A314 - 321
20X-RAY DIFFRACTION20A322 - 329
21X-RAY DIFFRACTION21H4 - 8
22X-RAY DIFFRACTION22H9 - 15
23X-RAY DIFFRACTION23H16 - 23
24X-RAY DIFFRACTION24H24 - 43
25X-RAY DIFFRACTION25H44 - 49
26X-RAY DIFFRACTION26H50 - 65
27X-RAY DIFFRACTION27H66 - 74
28X-RAY DIFFRACTION28H75 - 86
29X-RAY DIFFRACTION29H87 - 93
30X-RAY DIFFRACTION30H94 - 105
31X-RAY DIFFRACTION31H106 - 119
32X-RAY DIFFRACTION32H120 - 132
33X-RAY DIFFRACTION33H133 - 138
34X-RAY DIFFRACTION34H144 - 151
35X-RAY DIFFRACTION35H152 - 179
36X-RAY DIFFRACTION36H180 - 191
37X-RAY DIFFRACTION37H192 - 197
38X-RAY DIFFRACTION38H198 - 203
39X-RAY DIFFRACTION39H204 - 209
40X-RAY DIFFRACTION40H210 - 224
41X-RAY DIFFRACTION41L1 - 5
42X-RAY DIFFRACTION42L6 - 17
43X-RAY DIFFRACTION43L18 - 26
44X-RAY DIFFRACTION44L27 - 36
45X-RAY DIFFRACTION45L37 - 52
46X-RAY DIFFRACTION46L53 - 69
47X-RAY DIFFRACTION47L70 - 79
48X-RAY DIFFRACTION48L80 - 93
49X-RAY DIFFRACTION49L94 - 101
50X-RAY DIFFRACTION50L102 - 108
51X-RAY DIFFRACTION51L109 - 117
52X-RAY DIFFRACTION52L118 - 128
53X-RAY DIFFRACTION53L129 - 143
54X-RAY DIFFRACTION54L144 - 149
55X-RAY DIFFRACTION55L150 - 160
56X-RAY DIFFRACTION56L161 - 173
57X-RAY DIFFRACTION57L174 - 189
58X-RAY DIFFRACTION58L190 - 198
59X-RAY DIFFRACTION59L199 - 210
60X-RAY DIFFRACTION60L211 - 215

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