Entry | Database: PDB / ID: 6osp |
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Title | Crystal Structure Analysis of PIP4K2A |
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Components | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
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Keywords | TRANSFERASE / kinase / SIGNALING PROTEIN |
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Function / homology | Function and homology information
vesicle-mediated cholesterol transport / 1-phosphatidylinositol-5-phosphate 4-kinase / 1-phosphatidylinositol-5-phosphate 4-kinase activity / 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process / Synthesis of PIPs in the nucleus / 1-phosphatidylinositol-4-phosphate 5-kinase activity / autophagosome-lysosome fusion / positive regulation of autophagosome assembly / megakaryocyte development / PI5P Regulates TP53 Acetylation ...vesicle-mediated cholesterol transport / 1-phosphatidylinositol-5-phosphate 4-kinase / 1-phosphatidylinositol-5-phosphate 4-kinase activity / 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process / Synthesis of PIPs in the nucleus / 1-phosphatidylinositol-4-phosphate 5-kinase activity / autophagosome-lysosome fusion / positive regulation of autophagosome assembly / megakaryocyte development / PI5P Regulates TP53 Acetylation / Synthesis of PIPs at the plasma membrane / phosphatidylinositol phosphate biosynthetic process / photoreceptor outer segment / autophagosome / negative regulation of insulin receptor signaling pathway / photoreceptor inner segment / regulation of autophagy / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / lysosome / phosphorylation / protein homodimerization activity / nucleoplasm / ATP binding / plasma membrane / cytosolSimilarity search - Function Phosphatidylinositol Phosphate Kinase II Beta / Phosphatidylinositol Phosphate Kinase II Beta / Phosphatidylinositol Phosphate Kinase Iibeta; Chain: A, domain 2 / 2-Layer Sandwich / Phosphatidylinositol-4-phosphate 5-kinase / : / Phosphatidylinositol-4-phosphate 5-kinase, core / Phosphatidylinositol-4-phosphate 5-kinase, N-terminal / Phosphatidylinositol-4-phosphate 5-Kinase / Phosphatidylinositol phosphate kinase (PIPK) domain profile. ...Phosphatidylinositol Phosphate Kinase II Beta / Phosphatidylinositol Phosphate Kinase II Beta / Phosphatidylinositol Phosphate Kinase Iibeta; Chain: A, domain 2 / 2-Layer Sandwich / Phosphatidylinositol-4-phosphate 5-kinase / : / Phosphatidylinositol-4-phosphate 5-kinase, core / Phosphatidylinositol-4-phosphate 5-kinase, N-terminal / Phosphatidylinositol-4-phosphate 5-Kinase / Phosphatidylinositol phosphate kinase (PIPK) domain profile. / Phosphatidylinositol phosphate kinases / 2-Layer Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.21 Å |
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Authors | Seo, H.-S. / Dhe-Paganon, S. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | | United States |
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Citation | Journal: Cell Chem Biol / Year: 2020 Title: Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Authors: Sivakumaren, S.C. / Shim, H. / Zhang, T. / Ferguson, F.M. / Lundquist, M.R. / Browne, C.M. / Seo, H.S. / Paddock, M.N. / Manz, T.D. / Jiang, B. / Hao, M.F. / Krishnan, P. / Wang, D.G. / ...Authors: Sivakumaren, S.C. / Shim, H. / Zhang, T. / Ferguson, F.M. / Lundquist, M.R. / Browne, C.M. / Seo, H.S. / Paddock, M.N. / Manz, T.D. / Jiang, B. / Hao, M.F. / Krishnan, P. / Wang, D.G. / Yang, T.J. / Kwiatkowski, N.P. / Ficarro, S.B. / Cunningham, J.M. / Marto, J.A. / Dhe-Paganon, S. / Cantley, L.C. / Gray, N.S. |
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History | Deposition | May 1, 2019 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Apr 29, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jun 3, 2020 | Group: Database references / Category: citation / Item: _citation.journal_volume / _citation.page_first |
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Revision 1.2 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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