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TitleTargeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors.
Journal, issue, pagesCell Chem Biol, Vol. 27, Page 525-, Year 2020
Publish dateMay 1, 2019 (structure data deposition date)
AuthorsSivakumaren, S.C. / Shim, H. / Zhang, T. / Ferguson, F.M. / Lundquist, M.R. / Browne, C.M. / Seo, H.S. / Paddock, M.N. / Manz, T.D. / Jiang, B. ...Sivakumaren, S.C. / Shim, H. / Zhang, T. / Ferguson, F.M. / Lundquist, M.R. / Browne, C.M. / Seo, H.S. / Paddock, M.N. / Manz, T.D. / Jiang, B. / Hao, M.F. / Krishnan, P. / Wang, D.G. / Yang, T.J. / Kwiatkowski, N.P. / Ficarro, S.B. / Cunningham, J.M. / Marto, J.A. / Dhe-Paganon, S. / Cantley, L.C. / Gray, N.S.
External linksCell Chem Biol / PubMed:32130941
MethodsX-ray diffraction
Resolution2.21 Å
Structure data

PDB-6osp:
Crystal Structure Analysis of PIP4K2A
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

Chemicals

ChemComp-N51:
4-{[(2E)-4-(dimethylamino)but-2-enoyl]amino}-N-(3-{[6-(1H-indol-3-yl)pyrimidin-4-yl]amino}phenyl)benzamide

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase / SIGNALING PROTEIN

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