登録情報 | データベース: PDB / ID: 6nfj |
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タイトル | Structure of Beta-Klotho in Complex with FGF19 C-terminal peptide |
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要素 | - Beta-klotho
- Fibroblast growth factor 19
- Nanobody 30
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キーワード | SIGNALING PROTEIN / Klotho / FGF19 / Nanobody / receptor tyrosine kinase / signaling |
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機能・相同性 | 機能・相同性情報
negative regulation of bile acid biosynthetic process / betaKlotho-mediated ligand binding / positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway / fibroblast growth factor receptor binding / FGFR4 ligand binding and activation / Phospholipase C-mediated cascade; FGFR4 / fibroblast growth factor binding / PI-3K cascade:FGFR4 / PI3K Cascade / fibroblast growth factor receptor signaling pathway ...negative regulation of bile acid biosynthetic process / betaKlotho-mediated ligand binding / positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway / fibroblast growth factor receptor binding / FGFR4 ligand binding and activation / Phospholipase C-mediated cascade; FGFR4 / fibroblast growth factor binding / PI-3K cascade:FGFR4 / PI3K Cascade / fibroblast growth factor receptor signaling pathway / hydrolase activity, hydrolyzing O-glycosyl compounds / SHC-mediated cascade:FGFR4 / FRS-mediated FGFR4 signaling / regulation of cell migration / positive regulation of glucose import / Negative regulation of FGFR4 signaling / positive regulation of JNK cascade / animal organ morphogenesis / growth factor activity / Constitutive Signaling by Aberrant PI3K in Cancer / PIP3 activates AKT signaling / nervous system development / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / carbohydrate metabolic process / positive regulation of ERK1 and ERK2 cascade / cell differentiation / positive regulation of protein phosphorylation / negative regulation of gene expression / positive regulation of cell population proliferation / positive regulation of gene expression / extracellular space / extracellular region / plasma membrane / cytoplasm類似検索 - 分子機能 Fibroblast growth factor 15/19/21 / HBGF/FGF family signature. / Fibroblast growth factor family / Fibroblast growth factor / Acidic and basic fibroblast growth factor family. / Cytokine IL1/FGF / Glycosyl hydrolase family 1 / Glycoside hydrolase family 1 / Glycoside hydrolase superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_mammal.gif) Lama glama (ラマ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.19 Å |
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データ登録者 | Kuzina, E. / Schlessinger, J. / Lee, S. |
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引用 | ジャーナル: Proc. Natl. Acad. Sci. U.S.A. / 年: 2019 タイトル: Structures of ligand-occupied beta-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity. 著者: Kuzina, E.S. / Ung, P.M. / Mohanty, J. / Tome, F. / Choi, J. / Pardon, E. / Steyaert, J. / Lax, I. / Schlessinger, A. / Schlessinger, J. / Lee, S. |
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履歴 | 登録 | 2018年12月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年4月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年4月17日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_abbrev / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2019年4月24日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.3 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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