Entry Database : PDB / ID : 6ncg Structure visualization Downloads & linksTitle Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to pyridin-benzenesulfonamide inhibitor ComponentsSerine/threonine-protein kinase VRK2 Details Keywords TRANSFERASE / protein kinase domain / Structural Genomics / Structural Genomics Consortium / SGC / Transferase-Transferase Inhibitor ComplexFunction / homology Function and homology informationFunction Domain/homology Component
regulation of interleukin-1-mediated signaling pathway / Nuclear Envelope Breakdown / Initiation of Nuclear Envelope (NE) Reformation / RHOD GTPase cycle / regulation of MAPK cascade / RHOG GTPase cycle / RAC2 GTPase cycle / RAC3 GTPase cycle / RAC1 GTPase cycle / mitochondrial membrane ... regulation of interleukin-1-mediated signaling pathway / Nuclear Envelope Breakdown / Initiation of Nuclear Envelope (NE) Reformation / RHOD GTPase cycle / regulation of MAPK cascade / RHOG GTPase cycle / RAC2 GTPase cycle / RAC3 GTPase cycle / RAC1 GTPase cycle / mitochondrial membrane / nuclear envelope / cellular response to oxidative stress / protein autophosphorylation / non-specific serine/threonine protein kinase / protein domain specific binding / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / endoplasmic reticulum membrane / protein kinase binding / endoplasmic reticulum / signal transduction / protein-containing complex / ATP binding / nucleus / cytoplasm Similarity search - Function Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.45 Å DetailsAuthors dos Reis, C.V. / Chiodi, C.G. / de Souza, G.P. / Guimaraes, C. / Mascarello, A. / Gama, F. / Ferreira, M. / Counago, R.M. / Massirer, K.B. / Elkins, J.M. ...dos Reis, C.V. / Chiodi, C.G. / de Souza, G.P. / Guimaraes, C. / Mascarello, A. / Gama, F. / Ferreira, M. / Counago, R.M. / Massirer, K.B. / Elkins, J.M. / Arruda, P. / Edwards, A.M. / Structural Genomics Consortium (SGC) Funding support Brazil, 1items Details Hide detailsOrganization Grant number Country Sao Paulo Research Foundation (FAPESP) 13/50724-5 Brazil
CitationJournal : To Be Published Title : Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to pyridin-benzenesulfonamide inhibitorAuthors: dos Reis, C.V. / Chiodi, C.G. / de Souza, G.P. / Azevedo, H. / Guimaraes, C. / Mascarello, A. / Gama, F. / Ferreira, M. / Counago, R.M. / Massirer, K.B. / Arruda, P. / Elkins, J.M. / ... Authors : dos Reis, C.V. / Chiodi, C.G. / de Souza, G.P. / Azevedo, H. / Guimaraes, C. / Mascarello, A. / Gama, F. / Ferreira, M. / Counago, R.M. / Massirer, K.B. / Arruda, P. / Elkins, J.M. / Edwards, A.M. / Structural Genomics Consortium (SGC) History Deposition Dec 11, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 16, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Jan 1, 2020 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.2 Oct 11, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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