登録情報 | データベース: PDB / ID: 6myn |
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タイトル | Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to inhibitor R7 |
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要素 | Mitogen-activated protein kinase kinase kinase 14 |
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キーワード | TRANSFERASE/TRANSFERASE Inhibitor / NIK / kinase / TRANSFERASE / TRANSFERASE-TRANSFERASE Inhibitor complex |
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機能・相同性 | 機能・相同性情報
CD28 dependent PI3K/Akt signaling / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / Dectin-1 mediated noncanonical NF-kB signaling / NIK-->noncanonical NF-kB signaling / TNFR2 non-canonical NF-kB pathway / mitogen-activated protein kinase kinase kinase / non-canonical NF-kappaB signal transduction / MAP kinase kinase kinase activity / canonical NF-kappaB signal transduction / fibrillar center ...CD28 dependent PI3K/Akt signaling / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / Dectin-1 mediated noncanonical NF-kB signaling / NIK-->noncanonical NF-kB signaling / TNFR2 non-canonical NF-kB pathway / mitogen-activated protein kinase kinase kinase / non-canonical NF-kappaB signal transduction / MAP kinase kinase kinase activity / canonical NF-kappaB signal transduction / fibrillar center / cellular response to mechanical stimulus / defense response to virus / protein kinase activity / immune response / phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / nucleoplasm / ATP binding / cytosol類似検索 - 分子機能 Mitogen-activated protein (MAP) kinase kinase kinase 14 / M3K14, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain ...Mitogen-activated protein (MAP) kinase kinase kinase 14 / M3K14, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-K6Y / Mitogen-activated protein kinase kinase kinase 14類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.744 Å |
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データ登録者 | Harris, S.F. / Smith, M. / Barker, J. |
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引用 | ジャーナル: Acs Med.Chem.Lett. / 年: 2019タイトル: Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1). 著者: Feng, J.A. / Lee, P. / Alaoui, M.H. / Barrett, K. / Castanedo, G. / Godemann, R. / McEwan, P. / Wang, X. / Wu, P. / Zhang, Y. / Harris, S.F. / Staben, S.T.#1: ジャーナル: Acs Med.Chem.Lett. / 年: 2019タイトル: Structure based design of potent selective inhibitors of protein kinase D1 (PKD1) 著者: Feng, J.W. / Lee, P. / Alaoui, M.H. / Barrett, K. / Castaneda, G.M. / Godemann, R. / McEwan, P. / Wang, X. / Wu, P. / Zhang, Y. / Harris, S.F. / Staben, S.T. |
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履歴 | 登録 | 2018年11月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年8月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年8月14日 | Group: Data collection / Database references / カテゴリ: citation_author |
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改定 1.2 | 2019年10月2日 | Group: Data collection / Database references / カテゴリ: citation / citation_author |
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改定 1.3 | 2024年3月13日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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