Entry Database : PDB / ID : 6mi0 Structure visualization Downloads & linksTitle Crystal structure of the P450 domain of the CYP51-ferredoxin fusion protein from Methylococcus capsulatus, ligand-free state ComponentsCytochrome P450 51 Details Keywords OXIDOREDUCTASE / CYTOCHROME P450 FOLD / CYP51 / HEME / STEROL BIOSYNTHESISFunction / homology Function and homology informationFunction Domain/homology Component
sterol 14alpha-demethylase / steroid 7-alpha-hydroxylase activity / oxysterol 7-alpha-hydroxylase activity / bile acid biosynthetic process / cholesterol homeostasis / iron ion binding / heme binding Similarity search - Function 4Fe-4S single cluster domain / Cytochrome P450, E-class, group IV / Cytochrome p450 / Cytochrome P450 / 4Fe-4S ferredoxin-type iron-sulfur binding domain profile. / 4Fe-4S ferredoxin-type, iron-sulphur binding domain / Cytochrome P450 / Cytochrome P450 superfamily / Cytochrome P450 / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Methylococcus capsulatus (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.73 Å DetailsAuthors Hargrove, T. / Wawrzak, Z. / Lamb, D.C. / Lepesheva, G.I. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R01067871 United States
CitationJournal : Mol.Biol.Evol. / Year : 2020Title : Concerning P450 evolution: Structural Analyses Support Bacterial Origin of Sterol 14 alpha-Demethylases.Authors : Lamb, D.C. / Hargrove, T.Y. / Zhao, B. / Wawrzak, Z. / Goldstone, J.V. / Nes, W.D. / Kelly, S.L. / Waterman, M.R. / Stegeman, J.J. / Lepesheva, G.I. History Deposition Sep 18, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 10, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Jan 1, 2020 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.2 Jan 20, 2021 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.3 Oct 11, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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