登録情報 データベース : PDB / ID : 6mep 構造の表示 ダウンロードとリンクタイトル Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC3437 要素Tyrosine-protein kinase Mer 詳細 キーワード Transferase/Transferase Inhibitor / Macrocyclic / Drug Design / Fibrinolytic Agents / Humans / Models / Molecular / Protein Kinase Inhibitors / Proto-Oncogene Proteins / Pyrimidines / Receptor Protein-Tyrosine Kinases / Structure-Activity Relationship / Thrombosis / Transferase-Transferase Inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of leukocyte apoptotic process / negative regulation of lymphocyte activation / neutrophil clearance / natural killer cell differentiation / secretion by cell / negative regulation of cytokine production / vagina development / photoreceptor outer segment / phagocytosis / positive regulation of phagocytosis ... negative regulation of leukocyte apoptotic process / negative regulation of lymphocyte activation / neutrophil clearance / natural killer cell differentiation / secretion by cell / negative regulation of cytokine production / vagina development / photoreceptor outer segment / phagocytosis / positive regulation of phagocytosis / transmembrane receptor protein tyrosine kinase activity / substrate adhesion-dependent cell spreading / establishment of localization in cell / Cell surface interactions at the vascular wall / receptor protein-tyrosine kinase / platelet activation / cell migration / cell-cell signaling / retina development in camera-type eye / nervous system development / spermatogenesis / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor complex / cell surface receptor signaling pathway / protein phosphorylation / extracellular space / ATP binding / plasma membrane / cytoplasm 類似検索 - 分子機能 Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / Fibronectin type III domain / : / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain ... Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / Fibronectin type III domain / : / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.893 Å 詳細データ登録者 Da, C. / Zhang, D. / Stashko, M.A. / Cheng, A. / Hunter, D. / Norris-Drouin, J. / Graves, L. / Machius, M. / Miley, M.J. / DeRyckere, D. ...Da, C. / Zhang, D. / Stashko, M.A. / Cheng, A. / Hunter, D. / Norris-Drouin, J. / Graves, L. / Machius, M. / Miley, M.J. / DeRyckere, D. / Earp, H.S. / Graham, D.K. / Frye, S.V. / Wang, X. / Kireev, D. 引用ジャーナル : J.Am.Chem.Soc. / 年 : 2019タイトル : Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology.著者: Da, C. / Zhang, D. / Stashko, M. / Vasileiadi, E. / Parker, R.E. / Minson, K.A. / Huey, M.G. / Huelse, J.M. / Hunter, D. / Gilbert, T.S.K. / Norris-Drouin, J. / Miley, M. / Herring, L.E. / ... 著者 : Da, C. / Zhang, D. / Stashko, M. / Vasileiadi, E. / Parker, R.E. / Minson, K.A. / Huey, M.G. / Huelse, J.M. / Hunter, D. / Gilbert, T.S.K. / Norris-Drouin, J. / Miley, M. / Herring, L.E. / Graves, L.M. / DeRyckere, D. / Earp, H.S. / Graham, D.K. / Frye, S.V. / Wang, X. / Kireev, D. 履歴 登録 2018年9月6日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2019年9月11日 Provider : repository / タイプ : Initial release改定 1.1 2019年10月9日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2019年10月16日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID 改定 1.3 2024年3月13日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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