Entry Database : PDB / ID : 6jwn Structure visualization Downloads & linksTitle Crystal structure of the SPRY domain of SPSB2 in complex with cR9, a cyclic peptide inhibitor of SPSB-iNOS interaction ComponentsNitric oxide synthase, inducible SPRY domain-containing SOCS box protein 2 DetailsKeywords PROTEIN BINDING/INHIBITOR / PRY-SPRY / B30.2 / E3 ubiquitin ligase / inducible nitric oxide synthase / PROTEIN BINDING-INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of leukocyte mediated cytotoxicity / Inhibition of nitric oxide production / prostaglandin secretion / Nitric oxide stimulates guanylate cyclase / ubiquitin ligase-substrate adaptor activity / ROS and RNS production in phagocytes / regulation of cellular respiration / positive regulation of killing of cells of another organism / tetrahydrobiopterin binding / SCF ubiquitin ligase complex ... positive regulation of leukocyte mediated cytotoxicity / Inhibition of nitric oxide production / prostaglandin secretion / Nitric oxide stimulates guanylate cyclase / ubiquitin ligase-substrate adaptor activity / ROS and RNS production in phagocytes / regulation of cellular respiration / positive regulation of killing of cells of another organism / tetrahydrobiopterin binding / SCF ubiquitin ligase complex / arginine binding / cortical cytoskeleton / superoxide metabolic process / regulation of cytokine production involved in inflammatory response / peptidyl-cysteine S-nitrosylation / regulation of insulin secretion / peroxisomal matrix / nitric-oxide synthase (NADPH) / positive regulation of guanylate cyclase activity / nitric oxide mediated signal transduction / vesicle membrane / nitric-oxide synthase activity / arginine catabolic process / innate immune response in mucosa / negative regulation of blood pressure / response to hormone / nitric oxide biosynthetic process / cell redox homeostasis / cellular response to interferon-gamma / response to bacterium / Peroxisomal protein import / positive regulation of interleukin-8 production / positive regulation of interleukin-6 production / peroxisome / circadian rhythm / negative regulation of protein catabolic process / cellular response to xenobiotic stimulus / Antigen processing: Ubiquitination & Proteasome degradation / Neddylation / FMN binding / regulation of cell population proliferation / proteasome-mediated ubiquitin-dependent protein catabolic process / flavin adenine dinucleotide binding / ubiquitin-dependent protein catabolic process / NADP binding / response to lipopolysaccharide / calmodulin binding / Interleukin-4 and Interleukin-13 signaling / protein ubiquitination / response to hypoxia / cellular response to lipopolysaccharide / defense response to Gram-negative bacterium / intracellular signal transduction / oxidoreductase activity / inflammatory response / defense response to bacterium / negative regulation of gene expression / heme binding / perinuclear region of cytoplasm / protein homodimerization activity / nucleoplasm / metal ion binding / plasma membrane / nucleus / cytosol / cytoplasm Similarity search - Function SSB2, SOCS box domain / suppressors of cytokine signalling / SOCS box / SOCS box-like domain superfamily / SOCS box domain / SOCS_box / SOCS box domain profile. / SPRY domain / B30.2/SPRY domain / B30.2/SPRY domain profile. ... SSB2, SOCS box domain / suppressors of cytokine signalling / SOCS box / SOCS box-like domain superfamily / SOCS box domain / SOCS_box / SOCS box domain profile. / SPRY domain / B30.2/SPRY domain / B30.2/SPRY domain profile. / B30.2/SPRY domain superfamily / SPRY domain / Domain in SPla and the RYanodine Receptor. / Nitric-oxide synthase, eukaryote / Nitric oxide synthase, domain 2 superfamily / Nitric oxide synthase, domain 3 superfamily / Nitric oxide synthase, domain 1 superfamily / Nitric oxide synthase, N-terminal domain superfamily / Nitric oxide synthase, oxygenase domain / Nitric oxide synthase, N-terminal / Nitric oxide synthase (NOS) signature. / NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily / FAD binding domain / Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding / Flavodoxin-like / Flavoprotein pyridine nucleotide cytochrome reductase / Flavodoxin / Oxidoreductase NAD-binding domain / Oxidoreductase FAD/NAD(P)-binding / Flavodoxin-like domain profile. / Flavodoxin/nitric oxide synthase / Ferredoxin-NADP reductase (FNR), nucleotide-binding domain / Ferredoxin reductase-type FAD binding domain profile. / FAD-binding domain, ferredoxin reductase-type / Riboflavin synthase-like beta-barrel / Flavoprotein-like superfamily / Concanavalin A-like lectin/glucanase domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.61 Å DetailsAuthors Li, K. / Kuang, Z. Funding support China, 3items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China 31270817 China National Natural Science Foundation of China 81571539 China Ministry of Education (China) 21617443 China
CitationJournal : To Be Published Title : Crystal structure of SPSB2 in complex with cR9, a cyclic peptide inhibitor of SPSB-iNOS interactionAuthors : Li, K. / Kuang, Z. History Deposition Apr 21, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Apr 22, 2020 Provider : repository / Type : Initial release