Entry Database : PDB / ID : 5xn3 Structure visualization Downloads & linksTitle Crystal structure of SPSB2 in complex with a rational designed RGD containing cyclic peptide inhibitor of SPSB2-iNOS interaction ComponentsSPRY domain-containing SOCS box protein 2 cR8 peptide from NOS2 DetailsKeywords PROTEIN BINDING/INHIBITOR / E3 ubiquitin / ligase / cyclic peptide inhibitor / SPRY domain-containing / SOCS box protein / inducible nitric oxide synthase / nitric oxide / PROTEIN BINDING-INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of leukocyte mediated cytotoxicity / Inhibition of nitric oxide production / Nitric oxide stimulates guanylate cyclase / positive regulation of killing of cells of another organism / prostaglandin secretion / ROS and RNS production in phagocytes / regulation of cellular respiration / tetrahydrobiopterin binding / arginine binding / SCF ubiquitin ligase complex ... positive regulation of leukocyte mediated cytotoxicity / Inhibition of nitric oxide production / Nitric oxide stimulates guanylate cyclase / positive regulation of killing of cells of another organism / prostaglandin secretion / ROS and RNS production in phagocytes / regulation of cellular respiration / tetrahydrobiopterin binding / arginine binding / SCF ubiquitin ligase complex / cortical cytoskeleton / superoxide metabolic process / peptidyl-cysteine S-nitrosylation / regulation of cytokine production involved in inflammatory response / regulation of insulin secretion / peroxisomal matrix / ubiquitin-like ligase-substrate adaptor activity / nitric-oxide synthase (NADPH) / nitric oxide mediated signal transduction / nitric-oxide synthase activity / arginine catabolic process / nitric oxide biosynthetic process / negative regulation of blood pressure / response to hormone / cell redox homeostasis / innate immune response in mucosa / positive regulation of interleukin-8 production / negative regulation of protein catabolic process / Peroxisomal protein import / response to bacterium / circadian rhythm / cellular response to type II interferon / positive regulation of interleukin-6 production / cellular response to xenobiotic stimulus / Antigen processing: Ubiquitination & Proteasome degradation / FMN binding / peroxisome / NADP binding / Neddylation / flavin adenine dinucleotide binding / regulation of cell population proliferation / ubiquitin-dependent protein catabolic process / cellular response to lipopolysaccharide / proteasome-mediated ubiquitin-dependent protein catabolic process / Interleukin-4 and Interleukin-13 signaling / defense response to Gram-negative bacterium / response to lipopolysaccharide / calmodulin binding / response to hypoxia / intracellular signal transduction / protein ubiquitination / defense response to bacterium / inflammatory response / negative regulation of gene expression / heme binding / perinuclear region of cytoplasm / protein homodimerization activity / nucleoplasm / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function SSB2, SOCS box domain / : / suppressors of cytokine signalling / SOCS box / SOCS box-like domain superfamily / SOCS box domain / SOCS box domain profile. / SOCS_box / SPRY domain / B30.2/SPRY domain ... SSB2, SOCS box domain / : / suppressors of cytokine signalling / SOCS box / SOCS box-like domain superfamily / SOCS box domain / SOCS box domain profile. / SOCS_box / SPRY domain / B30.2/SPRY domain / B30.2/SPRY domain profile. / SPRY domain / B30.2/SPRY domain superfamily / Domain in SPla and the RYanodine Receptor. / Nitric-oxide synthase, eukaryote / Nitric oxide synthase, domain 2 superfamily / Nitric oxide synthase, domain 1 superfamily / Nitric oxide synthase, domain 3 superfamily / : / Nitric oxide synthase, N-terminal / Nitric oxide synthase, N-terminal domain superfamily / Nitric oxide synthase, oxygenase domain / Nitric oxide synthase (NOS) signature. / Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding / NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily / FAD binding domain / Flavodoxin-like / Flavoprotein pyridine nucleotide cytochrome reductase / Flavodoxin / Flavodoxin-like domain profile. / Flavodoxin/nitric oxide synthase / Oxidoreductase FAD/NAD(P)-binding / Oxidoreductase NAD-binding domain / FAD-binding domain, ferredoxin reductase-type / Ferredoxin-NADP reductase (FNR), nucleotide-binding domain / Ferredoxin reductase-type FAD binding domain profile. / Riboflavin synthase-like beta-barrel / Flavoprotein-like superfamily / Concanavalin A-like lectin/glucanase domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.34 Å DetailsAuthors You, T. / Kuang, Z. Funding support China, 2items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China 31270817 China National Natural Science Foundation of China 81571539 China
CitationJournal : Biochem. Biophys. Res. Commun. / Year : 2017Title : Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction.Authors : You, T. / Wang, Y. / Li, K. / Zhang, D. / Wei, H. / Luo, Y. / Li, H. / Lu, Y. / Su, X. / Kuang, Z. History Deposition May 17, 2017 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jun 14, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Jul 5, 2017 Group : Database references / Category : citationItem : _citation.country / _citation.journal_id_ASTM ... _citation.country / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title Revision 1.2 Nov 22, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag
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