登録情報 | データベース: PDB / ID: 6iql |
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タイトル | Crystal structure of dopamine receptor D4 bound to the subtype-selective ligand, L745870 |
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要素 | D(4) dopamine receptor,Soluble cytochrome b562,D(4) dopamine receptor |
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キーワード | SIGNALING PROTEIN / GPCR / DRD4 / L745870 / ligand / dimerization |
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機能・相同性 | 機能・相同性情報
Dopamine receptors / : / positive regulation of sodium:proton antiporter activity / dopamine neurotransmitter receptor activity, coupled via Gi/Go / : / response to histamine / : / epinephrine binding / dopamine neurotransmitter receptor activity / positive regulation of penile erection ...Dopamine receptors / : / positive regulation of sodium:proton antiporter activity / dopamine neurotransmitter receptor activity, coupled via Gi/Go / : / response to histamine / : / epinephrine binding / dopamine neurotransmitter receptor activity / positive regulation of penile erection / adenylate cyclase-inhibiting dopamine receptor signaling pathway / dopamine binding / negative regulation of voltage-gated calcium channel activity / G alpha (i) signalling events / regulation of dopamine metabolic process / negative regulation of vascular associated smooth muscle cell migration / regulation of neurotransmitter secretion / olfactory learning / short-term memory / vesicle membrane / fear response / synaptic transmission, dopaminergic / G protein-coupled serotonin receptor activity / inhibitory postsynaptic potential / positive regulation of kinase activity / regulation of postsynaptic neurotransmitter receptor internalization / negative regulation of synaptic transmission / norepinephrine binding / neurotransmitter receptor activity / G protein-coupled dopamine receptor signaling pathway / arachidonic acid secretion / regulation of synaptic vesicle exocytosis / regulation of postsynaptic membrane neurotransmitter receptor levels / plasma membrane => GO:0005886 / negative regulation of vascular associated smooth muscle cell proliferation / associative learning / positive regulation of excitatory postsynaptic potential / behavioral response to cocaine / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / GABA-ergic synapse / negative regulation of protein secretion / behavioral fear response / axon terminus / regulation of calcium-mediated signaling / response to amphetamine / adult locomotory behavior / electron transport chain / regulation of circadian rhythm / terminal bouton / SH3 domain binding / rhythmic process / cell cortex / chemical synaptic transmission / dendritic spine / periplasmic space / electron transfer activity / iron ion binding / axon / neuronal cell body / glutamatergic synapse / dendrite / heme binding / identical protein binding / membrane / metal ion binding / plasma membrane / cytoplasm類似検索 - 分子機能 Dopamine D4 receptor / Dopamine receptor family / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family)類似検索 - ドメイン・相同性 Chem-L74 / Soluble cytochrome b562 / D(4) dopamine receptor類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ)
![](img/tx_bacteria.gif) Escherichia coli (大腸菌) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.5 Å |
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データ登録者 | Zhou, Y. / Cao, C. / Zhang, X.C. |
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資金援助 | 中国, 3件 組織 | 認可番号 | 国 |
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Ministry of Science and Technology (China) | 2015CB910104 | 中国 | National Natural Science Foundation of China | 31470745 | 中国 | Chinese Academy of Sciences | XDB08020301 | 中国 |
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引用 | ジャーナル: Elife / 年: 2019 タイトル: Crystal structure of dopamine receptor D4 bound to the subtype selective ligand, L745870. 著者: Zhou, Y. / Cao, C. / He, L. / Wang, X. / Zhang, X.C. |
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履歴 | 登録 | 2018年11月8日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2019年12月4日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月22日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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