Entry | Database: PDB / ID: 6i79 |
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Title | SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 4 |
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Components | Sepiapterin reductase |
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Keywords | OXIDOREDUCTASE / SEPIAPTERIN-REDUCTASE / PROTEROS BIOSTRUCTURES GMBH |
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Function / homology | Function and homology information
sepiapterin reductase (L-erythro-7,8-dihydrobiopterin-forming) / sepiapterin reductase (NADP+) activity / aldo-keto reductase (NADPH) activity / tetrahydrobiopterin biosynthetic process / eNOS activation / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / nitric oxide biosynthetic process / NADP binding / extracellular exosome / nucleoplasm / cytosolSimilarity search - Function Sepiapterin reductase / : / short chain dehydrogenase / Short-chain dehydrogenase/reductase SDR / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.63 Å |
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Authors | Alen, J. / Schade, M. / Wagener, M. / Blaesse, M. |
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Citation | Journal: J.Med.Chem. / Year: 2019 Title: Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors. Authors: Alen, J. / Schade, M. / Wagener, M. / Christian, F. / Nordhoff, S. / Merla, B. / Dunkern, T.R. / Bahrenberg, G. / Ratcliffe, P. |
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History | Deposition | Nov 16, 2018 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jul 10, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 24, 2019 | Group: Data collection / Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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Revision 1.2 | May 15, 2024 | Group: Advisory / Data collection / Database references Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_unobs_or_zero_occ_atoms Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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