Entry Database : PDB / ID : 6hpq Structure visualization Downloads & linksTitle Crystal structure of human Pif1 helicase in complex with AMP-PNP, brominated crystal form. ComponentsATP-dependent DNA helicase PIF1 Details Keywords HYDROLASE / Pif1 / 5'-3' DNA helicase / Duplex Unwinding / Telomere Maintenance / DNA RepairFunction / homology Function and homology informationFunction Domain/homology Component
5'-3' DNA/RNA helicase activity / telomerase inhibitor activity / G-quadruplex DNA binding / mitochondrial genome maintenance / negative regulation of telomerase activity / regulation of telomere maintenance / DNA duplex unwinding / single-stranded DNA helicase activity / telomeric DNA binding / negative regulation of telomere maintenance via telomerase ... 5'-3' DNA/RNA helicase activity / telomerase inhibitor activity / G-quadruplex DNA binding / mitochondrial genome maintenance / negative regulation of telomerase activity / regulation of telomere maintenance / DNA duplex unwinding / single-stranded DNA helicase activity / telomeric DNA binding / negative regulation of telomere maintenance via telomerase / Telomere Extension By Telomerase / telomere maintenance via telomerase / replication fork / 5'-3' DNA helicase activity / DNA recombination / DNA replication / DNA helicase / chromosome, telomeric region / DNA repair / magnesium ion binding / ATP hydrolysis activity / mitochondrion / nucleoplasm / ATP binding Similarity search - Function Helicase / : / : / DNA helicase Pif1, 2B domain / DNA helicase Pif1-like / PIF1-like helicase / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 1.43 Å DetailsAuthors Ledikov, V.M. / Dehghani-Tafti, S. / Bax, B. / Sanders, C.M. / Antson, A.A. CitationJournal : Nucleic Acids Res. / Year : 2019Title : Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.Authors : Dehghani-Tafti, S. / Levdikov, V. / Antson, A.A. / Bax, B. / Sanders, C.M. History Deposition Sep 21, 2018 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 23, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Feb 13, 2019 Group : Data collection / Database references / Category : citation / citation_author / pdbx_database_procItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.year / _citation_author.identifier_ORCID / _citation_author.name Revision 1.2 Apr 17, 2019 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Derived calculations Category : citation / database_PDB_rev ... citation / database_PDB_rev / database_PDB_rev_record / pdbx_data_processing_status / pdbx_database_proc / pdbx_validate_close_contact / struct_conn / struct_conn_type Item : _citation.journal_volume / _citation.page_first / _citation.page_lastRevision 1.3 May 15, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id
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