登録情報 | データベース: PDB / ID: 6hl6 |
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タイトル | Factor Inhibiting HIF (FIH) in complex with zinc, NOG and iASPP(670-693) |
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要素 | - Hypoxia-inducible factor 1-alpha inhibitor
- RelA-associated inhibitor
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キーワード | GENE REGULATION / NON-HEME / DIOXYGENASE / OXYGENASE / METAL-BINDING / TRANSCRIPTION / DOUBLE STRANDED BETA-HELIX / DSBH / FACIAL TRIAD / ASPARAGINYL/ASPARTYL HYDROXYLASE / EPIGENETIC REGULATION / SIGNALING / ARD / BETA-HYDROXYLATION / ACTIVATOR-INHIBITOR / OXIDOREDUCTASE-PEPTIDE COMPLEX / OXIDOREDUCTASE / ANKYRIN REPEAT DOMAIN / APOPTOSIS / P53 BINDING PROTEIN / ANK REPEAT / SH3 DOMAIN / ANKYRIN REPEATS |
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機能・相同性 | 機能・相同性情報
multicellular organismal-level homeostasis / cardiac right ventricle morphogenesis / hypoxia-inducible factor-asparagine dioxygenase / : / embryonic camera-type eye development / [protein]-asparagine 3-dioxygenase activity / hair cycle / peptidyl-histidine dioxygenase activity / peptidyl-aspartic acid 3-dioxygenase activity / Cellular response to hypoxia ...multicellular organismal-level homeostasis / cardiac right ventricle morphogenesis / hypoxia-inducible factor-asparagine dioxygenase / : / embryonic camera-type eye development / [protein]-asparagine 3-dioxygenase activity / hair cycle / peptidyl-histidine dioxygenase activity / peptidyl-aspartic acid 3-dioxygenase activity / Cellular response to hypoxia / ventricular cardiac muscle tissue development / carboxylic acid binding / positive regulation of vasculogenesis / ankyrin repeat binding / oxygen sensor activity / Notch binding / Regulation of TP53 Activity through Association with Co-factors / intercellular bridge / negative regulation of Notch signaling pathway / NF-kappaB binding / positive regulation of myoblast differentiation / cardiac muscle contraction / post-embryonic development / positive regulation of cell differentiation / ferrous iron binding / multicellular organism growth / transcription corepressor activity / cell junction / cadherin binding / apoptotic process / regulation of transcription by RNA polymerase II / perinuclear region of cytoplasm / negative regulation of transcription by RNA polymerase II / protein homodimerization activity / zinc ion binding / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 RelA-associated inhibitor / RelA-associated inhibitor, SH3 domain / Clavaminate synthase-like / Hypoxia-inducible factor 1-alpha inhibitor, domain II / Cupin-like domain 8 / Cupin-like domain / Variant SH3 domain / A domain family that is part of the cupin metalloenzyme superfamily. / Jelly Rolls / JmjC domain ...RelA-associated inhibitor / RelA-associated inhibitor, SH3 domain / Clavaminate synthase-like / Hypoxia-inducible factor 1-alpha inhibitor, domain II / Cupin-like domain 8 / Cupin-like domain / Variant SH3 domain / A domain family that is part of the cupin metalloenzyme superfamily. / Jelly Rolls / JmjC domain / JmjC domain profile. / RmlC-like jelly roll fold / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Helix Hairpins / Jelly Rolls / Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 N-OXALYLGLYCINE / RelA-associated inhibitor / Hypoxia-inducible factor 1-alpha inhibitor類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.97 Å |
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データ登録者 | Leissing, T.M. / Chowdhury, R. / Clifton, I.J. / Lu, X. / Schofield, C.J. |
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資金援助 | 英国, 1件 組織 | 認可番号 | 国 |
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Engineering and Physical Sciences Research Council | P/G03706X/1 | 英国 |
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引用 | ジャーナル: To Be Published タイトル: Factor Inhibiting HIF (FIH) in complex with zinc, NOG and iASPP(670-693) 著者: Leissing, T.M. / Chowdhury, R. / Clifton, I.J. / Lu, X. / Schofield, C.J. |
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履歴 | 登録 | 2018年9月10日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年10月9日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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