Entry Database : PDB / ID : 6h5j Structure visualization Downloads & linksTitle Crystal structure of DHQ1 from Salmonella typhi covalently modified by ligand 4 Components3-dehydroquinate dehydratase Details Keywords LYASE / lyase activity / chorismate biosynthetic process / 3-dehydroquinase / covalent inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
3,4-dihydroxybenzoate biosynthetic process / 3-dehydroquinate dehydratase / 3-dehydroquinate dehydratase activity / chorismate biosynthetic process / aromatic amino acid family biosynthetic process / amino acid biosynthetic process Similarity search - Function : / 3-dehydroquinate dehydratase, active site / Dehydroquinase class I active site. / 3-dehydroquinate dehydratase type I / Type I 3-dehydroquinase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta Similarity search - Domain/homologyBiological species Salmonella typhi (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.4 Å DetailsAuthors Otero, J.M. / Maneiro, M. / Lence, E. / Sanz-Gaitero, M. / Thompson, P. / Hawkins, A.R. / Gonzalez-Bello, C. / van Raaij, M.J. Funding support Spain, 1items Details Hide detailsOrganization Grant number Country Spanish Ministry of Science, Innovation, and Universities BFU2014-53425-P Spain
CitationJournal : Org Chem Front / Year : 2019Title : Hydroxylammonium Derivatives for Selective Active-site Lysine Modification in the Anti-virulence Bacterial Target DHQ1 Enzyme.Authors : Maneiro, M. / Lence, E. / Sanz-Gaitero, M. / Otero, J.M. / van Raaij, M.J. / Thompson, P. / Hawkins, A.R. / Gonzalez-Bello, C. History Deposition Jul 24, 2018 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jul 24, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Aug 7, 2019 Group : Data collection / Database references / Structure summaryCategory : audit_author / citation / citation_authorItem : _audit_author.name / _citation.country / _citation.journal_id_ISSNRevision 1.2 Sep 11, 2019 Group : Data collection / Derived calculations / Structure summaryCategory : chem_comp / entity / pdbx_entity_nonpolyItem : _chem_comp.name / _entity.pdbx_description / _pdbx_entity_nonpoly.nameRevision 1.3 Oct 9, 2019 Group : Data collection / Database references / Category : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last
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