Entry | Database: PDB / ID: 6h1d |
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Title | Crystal structure of C21orf127-TRMT112 in complex with SAH |
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Components | - HemK methyltransferase family member 2
- Multifunctional methyltransferase subunit TRM112-like protein
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Keywords | GENE REGULATION / protein methyltransferase / histone methylation / complex / SAH |
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Function / homology | Function and homology information
histone H4K12 methyltransferase activity / eRF1 methyltransferase complex / protein-glutamine N-methyltransferase activity / arsonoacetate metabolic process / : / peptidyl-glutamine methylation / rRNA (guanine-N7)-methylation / tRNA methyltransferase activator activity / toxin metabolic process / site-specific DNA-methyltransferase (adenine-specific) activity ...histone H4K12 methyltransferase activity / eRF1 methyltransferase complex / protein-glutamine N-methyltransferase activity / arsonoacetate metabolic process / : / peptidyl-glutamine methylation / rRNA (guanine-N7)-methylation / tRNA methyltransferase activator activity / toxin metabolic process / site-specific DNA-methyltransferase (adenine-specific) activity / tRNA modification in the nucleus and cytosol / Methylation / protein methyltransferase activity / positive regulation of rRNA processing / S-adenosylmethionine-dependent methyltransferase activity / tRNA methylation / S-adenosyl-L-methionine binding / rRNA methylation / rRNA modification in the nucleus and cytosol / negative regulation of gene expression, epigenetic / Eukaryotic Translation Termination / transcription initiation-coupled chromatin remodeling / Transferases; Transferring one-carbon groups; Methyltransferases / positive regulation of cell growth / methylation / nucleic acid binding / protein heterodimerization activity / perinuclear region of cytoplasm / protein-containing complex / nucleoplasm / nucleus / cytosolSimilarity search - Function Eukaryotic/archaeal PrmC-related / Multifunctional methyltransferase subunit Trm112 / Trm112-like / Trm112p-like protein / Methyltransferase small domain / Methyltransferase small domain / N-6 Adenine-specific DNA methylases signature. / DNA methylase, N-6 adenine-specific, conserved site / S-adenosyl-L-methionine-dependent methyltransferase superfamilySimilarity search - Domain/homology S-ADENOSYL-L-HOMOCYSTEINE / Multifunctional methyltransferase subunit TRM112-like protein / Methyltransferase N6AMT1Similarity search - Component |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.94 Å |
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Authors | Wang, S. / Hermann, B. / Metzger, E. / Peng, L. / Einsle, O. / Schuele, R. |
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Funding support | Germany, 2items Organization | Grant number | Country |
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European Research Council | ERC AdGrant 322844 | Germany | German Research Foundation | SFB 992, 850, 746, Schu688/15-1 | Germany |
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Citation | Journal: Nat.Struct.Mol.Biol. / Year: 2019 Title: KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. Authors: Metzger, E. / Wang, S. / Urban, S. / Willmann, D. / Schmidt, A. / Offermann, A. / Allen, A. / Sum, M. / Obier, N. / Cottard, F. / Ulferts, S. / Preca, B.T. / Hermann, B. / Maurer, J. / ...Authors: Metzger, E. / Wang, S. / Urban, S. / Willmann, D. / Schmidt, A. / Offermann, A. / Allen, A. / Sum, M. / Obier, N. / Cottard, F. / Ulferts, S. / Preca, B.T. / Hermann, B. / Maurer, J. / Greschik, H. / Hornung, V. / Einsle, O. / Perner, S. / Imhof, A. / Jung, M. / Schule, R. |
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History | Deposition | Jul 11, 2018 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | May 22, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jan 17, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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