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- PDB-6gjv: apo-structure of IMPDH from Pseudomonas aeruginosa -

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Open data


ID or keywords:

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Basic information

Entry
Database: PDB / ID: 6gjv
Titleapo-structure of IMPDH from Pseudomonas aeruginosa
ComponentsInosine-5'-monophosphate dehydrogenase
KeywordsOXIDOREDUCTASE / Inosine-5'-monophosphate dehydrogenase
Function / homology
Function and homology information


IMP dehydrogenase activity / IMP dehydrogenase / GMP biosynthetic process / GTP biosynthetic process / ATP binding / identical protein binding / metal ion binding
Similarity search - Function
IMP dehydrogenase / GMP reductase domain / Inosine-5'-monophosphate dehydrogenase / IMP dehydrogenase / GMP reductase, conserved site / IMP dehydrogenase / GMP reductase signature. / IMP dehydrogenase/GMP reductase / IMP dehydrogenase / GMP reductase domain / CBS domain superfamily / Domain in cystathionine beta-synthase and other proteins. / CBS domain / CBS domain ...IMP dehydrogenase / GMP reductase domain / Inosine-5'-monophosphate dehydrogenase / IMP dehydrogenase / GMP reductase, conserved site / IMP dehydrogenase / GMP reductase signature. / IMP dehydrogenase/GMP reductase / IMP dehydrogenase / GMP reductase domain / CBS domain superfamily / Domain in cystathionine beta-synthase and other proteins. / CBS domain / CBS domain / CBS domain profile. / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta
Similarity search - Domain/homology
Inosine-5'-monophosphate dehydrogenase
Similarity search - Component
Biological speciesPseudomonas aeruginosa PAO1 (bacteria)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.11 Å
AuthorsLabesse, G. / Haouz, A. / Alexandre, T. / Munier-Lehmann, H.
CitationJournal: Eur J Med Chem / Year: 2019
Title: First-in-class allosteric inhibitors of bacterial IMPDHs.
Authors: Alexandre, T. / Lupan, A. / Helynck, O. / Vichier-Guerre, S. / Dugue, L. / Gelin, M. / Haouz, A. / Labesse, G. / Munier-Lehmann, H.
History
DepositionMay 17, 2018Deposition site: PDBE / Processing site: PDBE
Revision 1.0Feb 27, 2019Provider: repository / Type: Initial release
Revision 1.1Jan 17, 2024Group: Advisory / Data collection ...Advisory / Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Inosine-5'-monophosphate dehydrogenase
B: Inosine-5'-monophosphate dehydrogenase
C: Inosine-5'-monophosphate dehydrogenase
D: Inosine-5'-monophosphate dehydrogenase
E: Inosine-5'-monophosphate dehydrogenase
F: Inosine-5'-monophosphate dehydrogenase
G: Inosine-5'-monophosphate dehydrogenase
H: Inosine-5'-monophosphate dehydrogenase


Theoretical massNumber of molelcules
Total (without water)431,5108
Polymers431,5108
Non-polymers00
Water40,0472223
1


  • Idetical with deposited unit
  • defined by author&software
  • Evidence: SAXS, equilibrium centrifugation, mass spectrometry, scanning transmission electron microscopy
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area31180 Å2
ΔGint-195 kcal/mol
Surface area123610 Å2
MethodPISA
Unit cell
Length a, b, c (Å)115.304, 194.639, 122.924
Angle α, β, γ (deg.)90.000, 117.750, 90.000
Int Tables number4
Space group name H-MP1211

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Components

#1: Protein
Inosine-5'-monophosphate dehydrogenase / IMPDH


Mass: 53938.699 Da / Num. of mol.: 8
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Pseudomonas aeruginosa PAO1 / Gene: guaB, PA3770 / Production host: Escherichia coli (E. coli) / References: UniProt: Q9HXM5, IMP dehydrogenase
#2: Water ChemComp-HOH / water / Water


Mass: 18.015 Da / Num. of mol.: 2223 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.83 Å3/Da / Density % sol: 56.52 %
Crystal growTemperature: 291 K / Method: vapor diffusion
Details: ithium chloride 500 mM, ammonium sulphate 50 mM and PEG8000 8%

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: SOLEIL / Beamline: PROXIMA 1 / Wavelength: 0.91165 Å
DetectorType: DECTRIS PILATUS3 6M / Detector: PIXEL / Date: Apr 3, 2013
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.91165 Å / Relative weight: 1
ReflectionResolution: 2.11→49.352 Å / Num. all: 274340 / Num. obs: 274340 / % possible obs: 100 % / Redundancy: 3.4 % / Biso Wilson estimate: 33.28 Å2 / Rpim(I) all: 0.044 / Rrim(I) all: 0.081 / Rsym value: 0.057 / Net I/av σ(I): 10.4 / Net I/σ(I): 11.8 / Num. measured all: 941570
Reflection shell

Diffraction-ID: 1

Resolution (Å)Redundancy (%)Rmerge(I) obsMean I/σ(I) obsNum. unique obsRpim(I) allRrim(I) allRsym value% possible all
2.11-2.2230.4961.5399930.3850.6780.496100
2.22-2.363.50.3172.4378640.2360.4470.317100
2.36-2.523.50.2143.5355320.1580.2970.214100
2.52-2.723.50.1395.4331310.1030.1930.139100
2.72-2.983.50.0918.2304910.0670.1260.091100
2.98-3.343.50.05712.6276260.0420.0790.057100
3.34-3.853.50.03818.1243460.0280.0520.038100
3.85-4.723.60.02922205950.0210.0390.029100
4.72-6.673.50.02822.1159310.0210.0390.028100
6.67-49.3523.50.02514.788310.0190.0350.02599.7

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Phasing

PhasingMethod: molecular replacement
Phasing MRModel details: Phaser MODE: MR_AUTO
Highest resolutionLowest resolution
Rotation2.5 Å49.35 Å

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Processing

Software
NameVersionClassification
XDSSeptember 26, 2012data reduction
SCALA3.3.15data scaling
PHASER2.1.4phasing
PHENIX1.13_2998refinement
PDB_EXTRACT3.24data extraction
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 4DQW

4dqw


Resolution: 2.11→44.631 Å / SU ML: 0.21 / Cross valid method: THROUGHOUT / σ(F): 1.35 / Phase error: 18.59
RfactorNum. reflection% reflection
Rfree0.1908 13803 5.03 %
Rwork0.1595 --
obs0.161 274263 99.97 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å
Displacement parametersBiso max: 142.56 Å2 / Biso mean: 44.059 Å2 / Biso min: 16.83 Å2
Refinement stepCycle: final / Resolution: 2.11→44.631 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms23450 0 0 2223 25673
Biso mean---50.5 -
Num. residues----3177
LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Rfactor Rfree error: 0 / Total num. of bins used: 30 / % reflection obs: 100 %

Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkNum. reflection all
2.11-2.1340.29384870.250586879174
2.134-2.15910.27294650.241985999064
2.1591-2.18540.25554570.224986649121
2.1854-2.21310.25564550.21286529107
2.2131-2.24220.244490.204187219170
2.2422-2.27290.23744530.197986309083
2.2729-2.30540.23794630.198186899152
2.3054-2.33980.23344930.192485789071
2.3398-2.37630.22914780.187386749152
2.3763-2.41530.24854700.183786619131
2.4153-2.4570.21974840.175486589142
2.457-2.50160.2154160.171986979113
2.5016-2.54970.22294670.166986319098
2.5497-2.60180.18364400.149886599099
2.6018-2.65830.20714470.155987209167
2.6583-2.72020.19334520.157386729124
2.7202-2.78820.19964720.159286619133
2.7882-2.86360.19844580.164587009158
2.8636-2.94780.20784270.16886869113
2.9478-3.04290.20624800.163286649144
3.0429-3.15170.18074350.155387349169
3.1517-3.27780.19334450.157486789123
3.2778-3.42690.19044530.163687169169
3.4269-3.60750.1944440.151487229166
3.6075-3.83350.16854380.144587039141
3.8335-4.12920.16045000.13286569156
4.1292-4.54440.15085000.122586789178
4.5444-5.20110.15114480.127987159163
5.2011-6.54960.17524790.150987289207
6.5496-44.64090.17614480.174288279275
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
10.56130.06240.01470.99760.24311.559-0.0414-0.01-0.01060.04610.1198-0.1504-0.03890.1155-0.0810.28690.01560.05240.1749-0.03350.333638.1879.556948.5479
23.6377-0.43472.42281.110.46553.2794-0.50370.00860.27470.05340.21420.2792-0.6183-0.18440.33320.72870.0691-0.16750.81910.05450.904962.960411.425980.2493
31.22870.1383-0.38050.96430.01161.1416-0.07440.0542-0.1326-0.00770.0783-0.11950.0560.0474-0.01870.27040.00220.03430.1507-0.04380.307734.72968.66348.6683
41.25690.392-0.81460.9723-0.23841.14920.138-0.38940.16950.1091-0.0271-0.086-0.10560.3506-0.10730.18-0.0229-0.03820.3965-0.06030.261668.5502-28.92153.5847
5-0.1511-0.0537-0.13321.7091.68881.4748-0.0590.39010.0098-0.1679-0.1637-0.0489-0.4026-0.12750.17410.6836-0.27760.04990.5594-0.07190.658881.52656.850761.3883
6-0.6182-0.3047-0.07130.77630.59281.2687-0.0157-0.12430.07840.06860.0996-0.0991-0.22740.4508-0.08380.2927-0.1215-0.02420.6318-0.10880.429281.536-16.31157.3098
71.4669-0.3731-1.30871.32890.09052.18860.1193-0.13480.21340.0154-0.0314-0.0198-0.1323-0.0267-0.09880.1685-0.03-0.04910.3448-0.04670.272462.4485-27.266552.6178
81.25970.20240.52921.20710.90913.67810.18190.1790.1878-0.1557-0.023-0.0402-0.3197-0.05680.07420.22320.0150.03310.2382-0.01780.290512.66270.93230.9396
91.22580.4054-0.00650.5974-0.630.50320.1859-0.297-0.21260.106-0.20650.1330.1582-0.235-0.04640.2222-0.0941-0.03770.3927-0.00610.3175-4.4416-23.688148.3075
103.0767-0.6241.84783.40260.42122.06150.0856-0.302-0.37250.40490.01380.22660.4356-0.6238-0.0810.492-0.2467-0.05560.90690.08940.5608-18.3312-37.914173.8196
110.4273-0.1-0.81840.3234-0.41382.3268-0.0419-0.2147-0.16510.15290.01530.0664-0.021-0.31020.04730.3235-0.0901-0.06380.5571-0.0210.4262-10.7394-21.694564.8713
120.92131.0277-0.5021.3912-0.07771.34780.01080.0742-0.0864-0.1235-0.02750.10960.0308-0.21760.01060.18450.0047-0.06240.3489-0.00860.2922-4.6865-14.936828.8858
130.60850.15020.19552.1463-0.58341.9740.0945-0.1005-0.1065-0.05040.037-0.02860.13230.1681-0.12830.17290.0005-0.02690.3371-0.02910.326212.0053-14.031942.5305
145.8821.9322-1.63531.6451-1.53542.17070.2607-0.34870.03990.0406-0.28380.0752-0.2365-0.012-0.0190.2890.0482-0.02070.2992-0.05220.199313.988-5.151112.1493
151.92640.468-0.69191.5517-0.30662.6441-0.08540.2405-0.3244-0.316-0.0585-0.12730.3541-0.23520.13630.4145-0.0007-0.04070.2872-0.0290.297717.1266-26.4981-6.7201
165.63821.707-1.85953.4879-0.78613.4032-0.00310.376-0.614-0.5643-0.0158-0.05120.3463-0.39050.05690.523-0.0244-0.05150.3596-0.06050.28716.8594-27.5755-14.1384
171.96240.884-0.17281.80071.25161.28990.04990.1636-0.0015-0.2946-0.0282-0.01470.0504-0.0918-0.01570.44310.0542-0.02340.30690.04950.218323.5379-10.288-9.2802
181.07980.668-0.92061.90350.08731.01020.0875-0.043-0.0092-0.1381-0.11610.03720.0699-0.08030.00650.32070.0282-0.06560.34080.01960.253816.745-15.73632.683
196.7491-1.1739-2.08645.2813-0.51143.53110.6014-0.48240.40970.0265-0.865-1.6532-0.33771.15510.22890.5436-0.0464-0.07210.52690.25880.756831.0415-37.0358.9122
201.1261-0.6596-1.3592.88040.82951.53990.14180.0059-0.1227-0.1156-0.11260.3031-0.0676-0.3204-0.04750.24210.0084-0.06150.36950.01840.22587.7887-16.064110.0873
210.7926-0.2036-0.37070.5230.21580.79760.0055-0.17540.04180.0875-0.01190.0145-0.008-0.01060.02340.2261-0.0102-0.00560.22780.00160.204130.1064-45.148763.3611
223.222-1.58320.58682.6149-0.41023.74080.1469-0.24870.3973-0.1278-0.11350.1591-0.1125-0.4409-0.0380.3257-0.0072-0.00640.5055-0.05590.32040.6659-23.669886.9338
232.362-0.8532-0.92760.81740.50291.6976-0.0209-0.2136-0.21120.0286-0.01590.23720.1506-0.2268-0.00930.3586-0.0812-0.00920.35640.00610.277110.7366-40.263379.8769
242.63860.4972-0.80140.98060.41741.1318-0.0187-0.3203-0.040.14240.0337-0.0360.05880.2527-0.01360.24120.0302-0.03410.28940.04270.187544.6476-46.886167.9477
252.0047-0.4595-0.04151.38670.35530.787-0.12680.05140.1951-0.08720.10340.0062-0.0876-0.06530.02770.2483-0.015-0.03080.19130.02390.200530.3335-44.625152.3384
260.71430.60731.00431.97751.78663.24740.05380.02230.2032-0.1338-0.09280.1309-0.1024-0.23720.05680.3405-0.00260.03710.32530.04170.281631.61034.924110.1066
270.7797-0.3425-0.47840.47470.15090.15310.09520.03110.1256-0.11950.108-0.3387-0.13460.2466-0.21470.4041-0.09730.12720.4374-0.10610.473971.4981.76320.3982
283.84860.57330.83863.8151.03312.26690.1410.19630.1788-0.42780.1005-0.4444-0.18770.3419-0.25180.5724-0.03430.21890.3975-0.05060.564683.31082.2699-19.9099
292.64791.3955-0.92571.6954-1.2411.91570.0866-0.1550.1235-0.0242-0.1143-0.1858-0.17330.08410.03820.497-0.01670.13470.3437-0.05770.475175.05891.4899-14.0445
300.9423-0.1865-0.25611.06340.72180.92730.0918-0.04410.2899-0.22620.2191-0.2713-0.5220.5026-0.33420.4699-0.16090.15420.3911-0.07640.445161.735415.155311.2424
311.7709-0.1175-0.220.3921.00222.51260.03170.13430.0509-0.28350.0398-0.1319-0.2253-0.0247-0.06250.4052-0.03320.12090.2173-0.00340.334446.568513.555514.3154
322.4654-1.75780.29512.02530.92491.4492-0.1106-0.1143-0.10520.41050.1437-0.11880.34910.0441-0.06380.4428-0.02170.02580.27080.02240.319253.199-7.692112.6835
333.2599-0.57740.23521.09210.65370.9675-0.00180.15920.0355-0.31690.0294-0.0939-0.0278-0.0696-0.01390.395-0.03170.06960.28870.02870.268739.0429-0.02321.0626
345.76762.7352.18582.79651.81151.72080.0981-0.1977-0.0440.1288-0.1539-0.01460.22370.03780.0540.207-0.00410.01840.24230.00390.183566.8598-47.964130.5048
350.31130.0139-0.35760.5451-0.50091.9492-0.02530.1730.0676-0.22860.0337-0.1146-0.03830.2216-0.00240.2845-0.02920.0350.3031-0.00440.244671.05-36.08931.834
362.29870.6060.32844.29661.49271.74760.00470.18360.2218-0.87080.1092-0.3767-0.24290.1139-0.10610.4932-0.08170.12370.3816-0.08370.357578.4439-18.2145-24.719
373.16122.02420.85513.76510.87374.20510.12380.00330.05420.09930.0075-0.4657-0.29010.1266-0.18610.3791-0.03190.03440.3408-0.02670.372681.7092-21.7183-14.3457
381.82490.917-0.30092.145-1.15492.1843-0.14710.3369-0.1015-0.34890.0795-0.11650.29590.15960.05770.35-0.00250.08010.3258-0.04340.233569.5573-47.7345-0.8218
391.85811.2912-0.21961.0086-0.65562.08170.0442-0.0517-0.0088-0.0151-0.0418-0.05510.11230.051-0.01060.28250.01050.04160.1724-0.01330.224765.254-52.974613.6592
401.39120.3050.34452.8779-0.75481.69630.0969-0.04390.3396-0.2037-0.09720.4546-0.1158-0.11060.02340.2510.00880.00320.2654-0.06710.343460.8023-31.087112.8274
410.87810.3660.10792.1233-0.64422.24480.0034-0.1950.07090.1393-0.0629-0.1776-0.01950.26180.06080.1834-0.00540.0140.3039-0.02030.228674.0413-38.92825.4701
421.4002-0.0464-2.44461.12160.45895.73270.0722-0.15140.0237-0.0270.076-0.1126-0.14680.4016-0.11140.2969-0.0281-0.00440.2289-0.01380.295149.7142-59.190728.5233
431.98560.3416-0.61241.1264-0.39421.9961-0.13860.39560.0365-0.3640.18980.26020.0142-0.4193-0.03480.3292-0.0706-0.08960.27760.03540.260923.7693-61.832416.301
442.5622-0.0729-0.89552.22870.01644.0064-0.12870.4637-0.1055-0.47840.15680.30720.1435-0.5797-0.01440.3365-0.1144-0.11080.41120.01780.322418.1565-67.458616.9508
451.43040.0445-0.02171.0454-0.15122.1691-0.15210.1015-0.0506-0.02930.11970.12690.1567-0.21820.04160.305-0.063-0.00620.18760.02560.29124.7031-71.543131.5379
460.8075-0.2893-0.3950.29090.83733.081-0.0255-0.0750.1907-0.384-0.08720.131-0.47250.00060.10270.343-0.0241-0.03840.23050.01570.320433.2922-57.84635.2781
471.94260.3855-0.37770.1657-0.23631.52660.02820.12440.1209-0.0696-0.04760.0869-0.0711-0.00740.02120.2824-0.0294-0.01540.1711-0.01050.233936.136-59.95923.4038
484.7478-3.308-1.80597.37652.43045.2345-0.0183-0.8040.06570.81850.56490.8743-1.2169-0.2466-0.47320.85670.12520.08060.44620.14030.574921.808-38.793516.9926
493.33210.1670.65461.2699-0.35052.0408-0.00460.1305-0.0078-0.35810.0576-0.04390.1270.1407-0.04580.3473-0.06590.02350.2013-0.00050.243545.5759-59.413616.517
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain 'A' and (resid 1 through 87 )A1 - 87
2X-RAY DIFFRACTION2chain 'A' and (resid 88 through 202 )A88 - 202
3X-RAY DIFFRACTION3chain 'A' and (resid 203 through 467 )A203 - 467
4X-RAY DIFFRACTION4chain 'B' and (resid 1 through 75 )B1 - 75
5X-RAY DIFFRACTION5chain 'B' and (resid 76 through 133 )B76 - 133
6X-RAY DIFFRACTION6chain 'B' and (resid 134 through 326 )B134 - 326
7X-RAY DIFFRACTION7chain 'B' and (resid 327 through 467 )B327 - 467
8X-RAY DIFFRACTION8chain 'C' and (resid 0 through 24 )C0 - 24
9X-RAY DIFFRACTION9chain 'C' and (resid 25 through 105 )C25 - 105
10X-RAY DIFFRACTION10chain 'C' and (resid 106 through 166 )C106 - 166
11X-RAY DIFFRACTION11chain 'C' and (resid 167 through 219 )C167 - 219
12X-RAY DIFFRACTION12chain 'C' and (resid 220 through 337 )C220 - 337
13X-RAY DIFFRACTION13chain 'C' and (resid 338 through 467 )C338 - 467
14X-RAY DIFFRACTION14chain 'D' and (resid 1 through 24 )D1 - 24
15X-RAY DIFFRACTION15chain 'D' and (resid 25 through 88 )D25 - 88
16X-RAY DIFFRACTION16chain 'D' and (resid 89 through 238 )D89 - 238
17X-RAY DIFFRACTION17chain 'D' and (resid 239 through 315 )D239 - 315
18X-RAY DIFFRACTION18chain 'D' and (resid 316 through 371 )D316 - 371
19X-RAY DIFFRACTION19chain 'D' and (resid 372 through 428 )D372 - 428
20X-RAY DIFFRACTION20chain 'D' and (resid 429 through 467 )D429 - 467
21X-RAY DIFFRACTION21chain 'E' and (resid 1 through 98 )E1 - 98
22X-RAY DIFFRACTION22chain 'E' and (resid 99 through 138 )E99 - 138
23X-RAY DIFFRACTION23chain 'E' and (resid 139 through 238 )E139 - 238
24X-RAY DIFFRACTION24chain 'E' and (resid 239 through 337 )E239 - 337
25X-RAY DIFFRACTION25chain 'E' and (resid 338 through 467 )E338 - 467
26X-RAY DIFFRACTION26chain 'F' and (resid 1 through 24 )F1 - 24
27X-RAY DIFFRACTION27chain 'F' and (resid 25 through 127 )F25 - 127
28X-RAY DIFFRACTION28chain 'F' and (resid 128 through 177 )F128 - 177
29X-RAY DIFFRACTION29chain 'F' and (resid 178 through 206 )F178 - 206
30X-RAY DIFFRACTION30chain 'F' and (resid 207 through 266 )F207 - 266
31X-RAY DIFFRACTION31chain 'F' and (resid 267 through 337 )F267 - 337
32X-RAY DIFFRACTION32chain 'F' and (resid 338 through 428 )F338 - 428
33X-RAY DIFFRACTION33chain 'F' and (resid 429 through 467 )F429 - 467
34X-RAY DIFFRACTION34chain 'G' and (resid 1 through 24 )G1 - 24
35X-RAY DIFFRACTION35chain 'G' and (resid 25 through 98 )G25 - 98
36X-RAY DIFFRACTION36chain 'G' and (resid 99 through 177 )G99 - 177
37X-RAY DIFFRACTION37chain 'G' and (resid 178 through 202 )G178 - 202
38X-RAY DIFFRACTION38chain 'G' and (resid 203 through 266 )G203 - 266
39X-RAY DIFFRACTION39chain 'G' and (resid 267 through 337 )G267 - 337
40X-RAY DIFFRACTION40chain 'G' and (resid 338 through 428 )G338 - 428
41X-RAY DIFFRACTION41chain 'G' and (resid 429 through 467 )G429 - 467
42X-RAY DIFFRACTION42chain 'H' and (resid 1 through 24 )H1 - 24
43X-RAY DIFFRACTION43chain 'H' and (resid 25 through 88 )H25 - 88
44X-RAY DIFFRACTION44chain 'H' and (resid 89 through 238 )H89 - 238
45X-RAY DIFFRACTION45chain 'H' and (resid 239 through 288 )H239 - 288
46X-RAY DIFFRACTION46chain 'H' and (resid 289 through 315 )H289 - 315
47X-RAY DIFFRACTION47chain 'H' and (resid 316 through 371 )H316 - 371
48X-RAY DIFFRACTION48chain 'H' and (resid 372 through 428 )H372 - 428
49X-RAY DIFFRACTION49chain 'H' and (resid 429 through 467 )H429 - 467

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