登録情報 データベース : PDB / ID : 6fr2 構造の表示 ダウンロードとリンクタイトル Soluble epoxide hydrolase in complex with LK864 要素Bifunctional epoxide hydrolase 2 詳細 キーワード HYDROLASE / Inhibitor / Complex / sEH機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
lipid-phosphate phosphatase / 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity / stilbene catabolic process / phospholipid dephosphorylation / lipid phosphatase activity / Biosynthesis of maresins / soluble epoxide hydrolase / epoxide metabolic process / lysophosphatidic acid phosphatase activity / Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) ... lipid-phosphate phosphatase / 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity / stilbene catabolic process / phospholipid dephosphorylation / lipid phosphatase activity / Biosynthesis of maresins / soluble epoxide hydrolase / epoxide metabolic process / lysophosphatidic acid phosphatase activity / Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) / epoxide hydrolase activity / regulation of cholesterol metabolic process / dephosphorylation / phosphatase activity / peroxisomal matrix / toxic substance binding / cholesterol homeostasis / Peroxisomal protein import / response to toxic substance / peroxisome / positive regulation of gene expression / magnesium ion binding / protein homodimerization activity / extracellular exosome / cytosol 類似検索 - 分子機能 Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal / Phosphoglycolate phosphatase-like, domain 2 / HAD hydrolase, subfamily IA / Epoxide hydrolase-like / alpha/beta hydrolase fold / haloacid dehalogenase-like hydrolase / Alpha/beta hydrolase fold-1 / HAD superfamily / HAD-like superfamily / Alpha/Beta hydrolase fold, catalytic domain ... Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal / Phosphoglycolate phosphatase-like, domain 2 / HAD hydrolase, subfamily IA / Epoxide hydrolase-like / alpha/beta hydrolase fold / haloacid dehalogenase-like hydrolase / Alpha/beta hydrolase fold-1 / HAD superfamily / HAD-like superfamily / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.262 Å 詳細データ登録者 Kramer, J.S. / Pogoryelov, D. / Krasavin, M. / Proschak, E. 資金援助 ドイツ, 1件 詳細 詳細を隠す組織 認可番号 国 German Research Foundation PR1405/2-2 ドイツ
引用ジャーナル : Bioorg. Chem. / 年 : 2018タイトル : Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase.著者: Lukin, A. / Kramer, J. / Hartmann, M. / Weizel, L. / Hernandez-Olmos, V. / Falahati, K. / Burghardt, I. / Kalinchenkova, N. / Bagnyukova, D. / Zhurilo, N. / Rautio, J. / Forsberg, M. / ... 著者 : Lukin, A. / Kramer, J. / Hartmann, M. / Weizel, L. / Hernandez-Olmos, V. / Falahati, K. / Burghardt, I. / Kalinchenkova, N. / Bagnyukova, D. / Zhurilo, N. / Rautio, J. / Forsberg, M. / Ihalainen, J. / Auriola, S. / Leppanen, J. / Konstantinov, I. / Pogoryelov, D. / Proschak, E. / Dar'in, D. / Krasavin, M. 履歴 登録 2018年2月15日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2018年9月12日 Provider : repository / タイプ : Initial release改定 1.1 2021年2月24日 Group : Derived calculationsカテゴリ : pdbx_struct_assembly / pdbx_struct_assembly_gen ... pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop / pdbx_struct_oper_list Item : _pdbx_struct_assembly.details / _pdbx_struct_assembly.method_details ... _pdbx_struct_assembly.details / _pdbx_struct_assembly.method_details / _pdbx_struct_assembly.oligomeric_count / _pdbx_struct_assembly.oligomeric_details 改定 1.2 2024年1月17日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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