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-Structure paper
Title | Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase. |
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Journal, issue, pages | Bioorg. Chem., Vol. 80, Page 655-667, Year 2018 |
Publish date | Feb 15, 2018 (structure data deposition date) |
Authors | Lukin, A. / Kramer, J. / Hartmann, M. / Weizel, L. / Hernandez-Olmos, V. / Falahati, K. / Burghardt, I. / Kalinchenkova, N. / Bagnyukova, D. / Zhurilo, N. ...Lukin, A. / Kramer, J. / Hartmann, M. / Weizel, L. / Hernandez-Olmos, V. / Falahati, K. / Burghardt, I. / Kalinchenkova, N. / Bagnyukova, D. / Zhurilo, N. / Rautio, J. / Forsberg, M. / Ihalainen, J. / Auriola, S. / Leppanen, J. / Konstantinov, I. / Pogoryelov, D. / Proschak, E. / Dar'in, D. / Krasavin, M. |
External links | Bioorg. Chem. / PubMed:30059891 |
Methods | X-ray diffraction |
Resolution | 2.262 Å |
Structure data | PDB-6fr2: |
Chemicals | ChemComp-E3N: ChemComp-MG: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / Inhibitor / Complex / sEH |