登録情報 データベース : PDB / ID : 6fon 構造の表示 ダウンロードとリンクタイトル Elongated conformer of the human copper chaperone for SOD1 complexed with human SOD1 要素Copper chaperone for superoxide dismutase Superoxide dismutase [Cu-Zn] 詳細キーワード METAL BINDING PROTEIN / chaperone / zinc / copper / heterodimer機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
protein maturation by copper ion transfer / superoxide dismutase copper chaperone activity / action potential initiation / neurofilament cytoskeleton organization / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / protein phosphatase 2B binding / regulation of organ growth / relaxation of vascular associated smooth muscle / response to superoxide / anterograde axonal transport ... protein maturation by copper ion transfer / superoxide dismutase copper chaperone activity / action potential initiation / neurofilament cytoskeleton organization / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / protein phosphatase 2B binding / regulation of organ growth / relaxation of vascular associated smooth muscle / response to superoxide / anterograde axonal transport / peripheral nervous system myelin maintenance / regulation of T cell differentiation in thymus / retina homeostasis / superoxide anion generation / negative regulation of cholesterol biosynthetic process / hydrogen peroxide biosynthetic process / auditory receptor cell stereocilium organization / retrograde axonal transport / regulation of protein kinase activity / myeloid cell homeostasis / muscle cell cellular homeostasis / regulation of GTPase activity / superoxide metabolic process / heart contraction / superoxide dismutase / positive regulation of catalytic activity / transmission of nerve impulse / negative regulation of reproductive process / Detoxification of Reactive Oxygen Species / negative regulation of developmental process / superoxide dismutase activity / regulation of multicellular organism growth / protein-disulfide reductase activity / response to axon injury / neuronal action potential / ectopic germ cell programmed cell death / ovarian follicle development / positive regulation of phagocytosis / axon cytoplasm / embryo implantation / dendrite cytoplasm / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / removal of superoxide radicals / reactive oxygen species metabolic process / glutathione metabolic process / : / positive regulation of superoxide anion generation / thymus development / regulation of mitochondrial membrane potential / positive regulation of cytokine production / locomotory behavior / determination of adult lifespan / sensory perception of sound / placenta development / response to hydrogen peroxide / mitochondrial intermembrane space / regulation of blood pressure / small GTPase binding / negative regulation of inflammatory response / peroxisome / Platelet degranulation / gene expression / cellular response to oxidative stress / protein-folding chaperone binding / response to heat / cytoplasmic vesicle / spermatogenesis / response to ethanol / intracellular iron ion homeostasis / negative regulation of neuron apoptotic process / positive regulation of MAPK cascade / mitochondrial matrix / response to xenobiotic stimulus / cadherin binding / positive regulation of apoptotic process / copper ion binding / neuronal cell body / apoptotic process / protein-containing complex / mitochondrion / extracellular space / zinc ion binding / extracellular exosome / extracellular region / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 Heavy-metal-associated domain / Heavy metal-associated domain superfamily / Heavy-metal-associated domain profile. / Heavy metal-associated domain, HMA / Copper/Zinc superoxide dismutase signature 1. / Superoxide dismutase, copper/zinc, binding site / Copper/Zinc superoxide dismutase signature 2. / Superoxide dismutase, copper/zinc binding domain / Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone / Copper/zinc superoxide dismutase (SODC) / Superoxide dismutase-like, copper/zinc binding domain superfamily 類似検索 - ドメイン・相同性 Copper chaperone for superoxide dismutase / Superoxide dismutase [Cu-Zn] 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.05 Å 詳細データ登録者 Wright, G.S.A. / Sala, F.A. / Antonyuk, S.V. / Garratt, R.C. / Hasnain, S.S. 資金援助 英国, ブラジル, 6件 詳細 詳細を隠す組織 認可番号 国 Motor Neurone Disease Association Hasnain/Apr15/833-791 英国 Medical Research Council (United Kingdom) MRF-060-0002-RG-HASNA 英国 Sao Paulo Research Fundation 2015/00062-1 ブラジル Sao Paulo Research Fundation 2016/24686-7 ブラジル National Council for Scientific and Technological Development 407438/2013-0 ブラジル National Council for Scientific and Technological Development (CNPq) 407438/2013-0 ブラジル
引用ジャーナル : Plos Biol. / 年 : 2019タイトル : Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS.著者 : Sala, F.A. / Wright, G.S.A. / Antonyuk, S.V. / Garratt, R.C. / Hasnain, S.S. 履歴 登録 2018年2月7日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2019年1月30日 Provider : repository / タイプ : Initial release改定 1.1 2019年6月19日 Group : Data collection / Database referencesカテゴリ : citation / citation_author / pdbx_database_procItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name 改定 1.2 2024年1月17日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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