登録情報 | データベース: PDB / ID: 6fc1 |
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タイトル | Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae in the cap-bound state |
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要素 | - Eukaryotic translation initiation factor 4E
- Protein EAP1
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キーワード | TRANSLATION / Gene expression Translation Translation initiation Translational control |
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機能・相同性 | 機能・相同性情報
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / positive regulation of formation of translation preinitiation complex / Deadenylation of mRNA / : / eukaryotic initiation factor 4E binding / eukaryotic translation initiation factor 4F complex / deadenylation-dependent decapping of nuclear-transcribed mRNA / mRNA cap binding / RNA 7-methylguanosine cap binding / phosphatidylinositol-3-phosphate binding ...Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / positive regulation of formation of translation preinitiation complex / Deadenylation of mRNA / : / eukaryotic initiation factor 4E binding / eukaryotic translation initiation factor 4F complex / deadenylation-dependent decapping of nuclear-transcribed mRNA / mRNA cap binding / RNA 7-methylguanosine cap binding / phosphatidylinositol-3-phosphate binding / regulation of translational initiation / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / Translation initiation complex formation / Ribosomal scanning and start codon recognition / mRNA catabolic process / L13a-mediated translational silencing of Ceruloplasmin expression / translation initiation factor activity / translational initiation / cytoplasmic stress granule / regulation of cell cycle / negative regulation of translation / ribosome / mRNA binding / ATP binding / nucleus / cytoplasm類似検索 - 分子機能 eIF4E-associated protein / eIF4E-associated protein / RNA Cap, Translation Initiation Factor Eif4e / RNA Cap, Translation Initiation Factor Eif4e / Eukaryotic translation initiation factor 4E (eIF-4E), conserved site / Eukaryotic initiation factor 4E signature. / Translation Initiation factor eIF- 4e / Eukaryotic initiation factor 4E / Translation Initiation factor eIF- 4e-like / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE / Eukaryotic translation initiation factor 4E / Protein EAP1類似検索 - 構成要素 |
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生物種 | ![](img/tx_yeast.gif) Saccharomyces cerevisiae S288C (パン酵母) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.35 Å |
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データ登録者 | Gruener, S. / Valkov, E. |
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引用 | ジャーナル: Nucleic Acids Res. / 年: 2018 タイトル: Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast. 著者: Gruner, S. / Weber, R. / Peter, D. / Chung, M.Y. / Igreja, C. / Valkov, E. / Izaurralde, E. |
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履歴 | 登録 | 2017年12月20日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2018年6月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年8月8日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name |
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改定 1.2 | 2024年1月17日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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