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Yorodumi- PDB-6f2x: Structural characterization of the Mycobacterium tuberculosis Pro... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6f2x | ||||||||||||
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Title | Structural characterization of the Mycobacterium tuberculosis Protein Tyrosine Kinase A (PtkA) | ||||||||||||
Components | Protein Tyrosine Kinase A | ||||||||||||
Keywords | TRANSFERASE / tyrosine kinase phosphorylation Mycobacterium tuberculosis | ||||||||||||
Function / homology | Function and homology information Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases / : / protein tyrosine kinase activity / protein autophosphorylation / ATP binding / cytosol Similarity search - Function | ||||||||||||
Biological species | Mycobacterium tuberculosis (bacteria) | ||||||||||||
Method | SOLUTION NMR / simulated annealing with torsion angle dynamics / cartesian angle dynamics / molecular dynamics | ||||||||||||
Authors | Niesteruk, A. / Jonker, H.R.A. / Sreeramulu, S. / Richter, C. / Hutchison, M. / Linhard, V. / Schwalbe, H. | ||||||||||||
Funding support | Germany, 3items
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Citation | Journal: J. Biol. Chem. / Year: 2018 Title: The domain architecture of PtkA, the first tyrosine kinase fromMycobacterium tuberculosis, differs from the conventional kinase architecture. Authors: Niesteruk, A. / Jonker, H.R.A. / Richter, C. / Linhard, V. / Sreeramulu, S. / Schwalbe, H. #1: Journal: FEBS Lett. / Year: 2018 Title: Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A. Authors: Niesteruk, A. / Hutchison, M. / Sreeramulu, S. / Jonker, H.R.A. / Richter, C. / Abele, R. / Bock, C. / Schwalbe, H. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6f2x.cif.gz | 1.2 MB | Display | PDBx/mmCIF format |
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PDB format | pdb6f2x.ent.gz | 1 MB | Display | PDB format |
PDBx/mmJSON format | 6f2x.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/f2/6f2x ftp://data.pdbj.org/pub/pdb/validation_reports/f2/6f2x | HTTPS FTP |
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-Related structure data
Similar structure data | |
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Other databases |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 22874.760 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (bacteria) Gene: Rv2232, MTCY427.13/MTCY427.14 / Plasmid: pET151/D-TOPO / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: P9WPI9 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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-Sample preparation
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Sample |
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