Crystal structure of mouse PP2A Aalpha P179R mutant
Components
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Keywords
PROTEIN BINDING / PP2A / Aalpha
Function / homology
Function and homology information
Inhibition of replication initiation of damaged DNA by RB1/E2F1 / ERKs are inactivated / Initiation of Nuclear Envelope (NE) Reformation / Cyclin A/B1/B2 associated events during G2/M transition / CTLA4 inhibitory signaling / Beta-catenin phosphorylation cascade / Disassembly of the destruction complex and recruitment of AXIN to the membrane / Negative regulation of MAPK pathway / Spry regulation of FGF signaling / Regulation of TP53 Degradation ...Inhibition of replication initiation of damaged DNA by RB1/E2F1 / ERKs are inactivated / Initiation of Nuclear Envelope (NE) Reformation / Cyclin A/B1/B2 associated events during G2/M transition / CTLA4 inhibitory signaling / Beta-catenin phosphorylation cascade / Disassembly of the destruction complex and recruitment of AXIN to the membrane / Negative regulation of MAPK pathway / Spry regulation of FGF signaling / Regulation of TP53 Degradation / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / meiotic spindle elongation / RAF activation / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / Cyclin D associated events in G1 / PKR-mediated signaling / mitotic sister chromatid separation / regulation of meiotic cell cycle process involved in oocyte maturation / Degradation of beta-catenin by the destruction complex / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / Resolution of Sister Chromatid Cohesion / protein phosphatase type 2A complex / meiotic sister chromatid cohesion, centromeric / DARPP-32 events / RHO GTPases Activate Formins / Separation of Sister Chromatids / Platelet sensitization by LDL / Loss of Nlp from mitotic centrosomes / Recruitment of mitotic centrosome proteins and complexes / Loss of proteins required for interphase microtubule organization from the centrosome / Recruitment of NuMA to mitotic centrosomes / ERK/MAPK targets / Anchoring of the basal body to the plasma membrane / female meiotic nuclear division / AURKA Activation by TPX2 / protein antigen binding / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / protein phosphatase regulator activity / Regulation of PLK1 Activity at G2/M Transition / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / protein serine/threonine phosphatase activity / T cell homeostasis / chromosome, centromeric region / lateral plasma membrane / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / chromosome segregation / protein heterodimerization activity / neuronal cell body / glutamatergic synapse / synapse / dendrite / nucleus / cytoplasm / cytosol Similarity search - Function
Resolution: 3.4→48.79 Å / Cor.coef. Fo:Fc: 0.955 / Cor.coef. Fo:Fc free: 0.961 / SU B: 25.45 / SU ML: 0.383 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R Free: 0.424 / Stereochemistry target values: MAXIMUM LIKELIHOOD Details: HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT U VALUES : REFINED INDIVIDUALLY
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.2353
884
5.1 %
RANDOM
Rwork
0.2187
-
-
-
obs
0.2196
16510
99.41 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK
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