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Open data
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Basic information
Entry | Database: PDB / ID: 6ecj | |||||||||
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Title | Human cytochrome c G41T | |||||||||
![]() | Cytochrome c | |||||||||
![]() | APOPTOSIS / cytochrome c / heme / glycine to threonine substitution | |||||||||
Function / homology | ![]() Formation of apoptosome / apoptosome / Release of apoptotic factors from the mitochondria / Respiratory electron transport / Activation of caspases through apoptosome-mediated cleavage / Regulation of the apoptosome activity / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / cellular respiration / mitochondrial electron transport, cytochrome c to oxygen ...Formation of apoptosome / apoptosome / Release of apoptotic factors from the mitochondria / Respiratory electron transport / Activation of caspases through apoptosome-mediated cleavage / Regulation of the apoptosome activity / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / cellular respiration / mitochondrial electron transport, cytochrome c to oxygen / execution phase of apoptosis / mitochondrial electron transport, ubiquinol to cytochrome c / Detoxification of Reactive Oxygen Species / Pyroptosis / : / intrinsic apoptotic signaling pathway / TP53 Regulates Metabolic Genes / Transcriptional activation of mitochondrial biogenesis / Cytoprotection by HMOX1 / mitochondrial intermembrane space / mitochondrial inner membrane / electron transfer activity / heme binding / mitochondrion / nucleus / metal ion binding / cytosol Similarity search - Function | |||||||||
Biological species | ![]() | |||||||||
Method | ![]() ![]() ![]() ![]() | |||||||||
Model details | G41T variant | |||||||||
![]() | Fellner, M. / Jameson, G.N.L. / Ledgerwood, E.C. / Wilbanks, S.M. | |||||||||
![]() | ![]() Title: Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity. Authors: Fellner, M. / Parakra, R. / McDonald, K.O. / Kass, I. / Jameson, G.N.L. / Wilbanks, S.M. / Ledgerwood, E.C. | |||||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 182.7 KB | Display | ![]() |
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PDB format | ![]() | 144.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 5exqC ![]() 3nwvS S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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